Results 111 to 120 of about 533,242 (221)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, Volume 20, Issue 11, Page 2839-2859, November 2026.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Age‐linked biological context shapes adaptive immunity in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 11, November 2026.
Abstract Alzheimer's disease (AD) is increasingly recognized as a neuroimmune disorder with protective or pathogenic adaptive immunity dependent on the biological context. This review synthesizes evidence from human studies, genetic analyses, mouse models, and clinical trials to examine how lymphocytes and humoral immunity influence AD.
Sophie Shirenova, Arya Biragyn, Eitan Okun   +2 more
wiley   +1 more source

Hypersensitivity to glucagon‐like peptide‐1 receptor agonists: A case of delayed urticaria‐like rash to dulaglutide and literature review

JEADV Clinical Practice
Dulaglutide is a glucagon‐like peptide‐1 (GLP‐1) receptor agonist, which stimulates insulin release via activation of GLP‐1 receptors on pancreatic beta cells.
Leonardo Bianchi, Samane Ali Biglu Marash, Nicolò Malatesta, Katharina Hansel, Marta Tramontana, Luca Stingeni   +5 more
doaj   +1 more source

Once-weekly Insulin Icodec – An emerging treatment option for type 2 Diabetes

Journal of the Pakistan Medical Association
The treatment of diabetes often necessitates the administration of exogenous insulin, but research shows that patients are less compliant with administering insulin daily.
Rubab Zahra, Fasiha Tariq, Mushood Ahmed
doaj   +1 more source

New therapeutic options for metabolic‐associated steatotic liver disease

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3770-3777, November 2026.
An increasing number of patients are being diagnosed with metabolic dysfunction‐associated steatotic liver disease (MASLD). MASLD results from disturbances in hepatic lipid metabolism and is associated with an increased risk of cirrhosis and hepatocellular carcinoma and significant extrahepatic morbidity, including cardiovascular disease and ...
Tessa Straatmijer, Midas Mulder
wiley   +1 more source

Inflammatory and Insulin Resistance Indicator for Predicting Repeat Revascularization and In‐Stent Restenosis in Patients With Chronic Coronary Syndrome Undergoing Percutaneous Coronary Intervention

Clinical Cardiology, Volume 49, Issue 11, November 2026.
In patients with chronic coronary syndrome undergoing PCI, higher baseline CTI was independently associated with repeat revascularization and in‐stent restenosis. However, its incremental predictive value beyond conventional risk factors was limited, highlighting the need for further validation.
Wang Jiale, Liu Longcheng, Lu Peipei, Ma Lihong   +3 more
wiley   +1 more source

Remission of diabetes mellitus induced by prednisolone in combination with cyclosporine toxicity in a cat

Veterinary Medicine and Science
A 6‐year‐old spayed female domestic short‐hair cat was presented for primary complaints of anorexia and lethargy. The cat was being treated with cyclosporine (25 mg/cat, PO q24h) and prednisolone (1 mg/kg, PO q12h) for feline hypersensitivity dermatitis ...
Sijin Cha, Yoonhoi Koo, Yujin Choi, Yeon Chae, Dohee Lee, Taesik Yun, Mhan‐Pyo Yang, Byeong‐Teck Kang, Hakhyun Kim   +8 more
doaj   +1 more source

Management of advanced mycosis fungoides and Sézary Syndrome: International Recommendations for systemic treatments and allogeneic hematopoietic cell transplantation from the European Hematology Association, the EORTC Cutaneous Lymphoma Tumours Group, the International Society for Cutaneous Lymphoma, and the Lymphoma Working Party of the EBMT

HemaSphere, Volume 10, Issue 11, November 2026.
Abstract Advanced mycosis fungoides (MF) and Sézary syndrome (SS) are the most aggressive forms of cutaneous T‐cell lymphoma and remain associated with a poor prognosis and heterogeneous therapeutic approaches. Recent advances, including targeted therapies and improved transplant strategies, have substantially expanded treatment options, highlighting ...
Francesco Onida, Pietro Quaglino, Julia Scarisbrick, Anna Sureda, Emmilia Hodak, Evangelia Papadavid, Silvia Alberti‐Violetti, Martine Bagot, Lorenzo Cerroni, Amrita Goyal‐O'Leary, Rudolf Stadler, Rein Willemze, Jasmine Zain, Marco Ardigò, Emilio Berti, Adèle de Masson, Rafael F. Duarte, Francine Foss, Eva González‐Barca, Joan Guitart, Pablo Ortiz‐Romero, Alessandro Pileri, Pierluigi Porcu, Henry M. Prince, Sima Rozati, Serena Rupoli, Maarten H. Vermeer, Sean Whittaker, Nicola Pimpinelli, Pier Luigi Zinzani   +29 more
wiley   +1 more source

Neointimal Hyperplasia and Restenosis: Epidemiology, Pathophysiology, Animal Models, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
The overall graphical diagram to summarize the pathological characteristics, pathogenesis, clinical manifestation, preclinical animal models, diagnostic methods, and intervention strategies for neointimal hyperplasia. Neointimal hyperplasia results from excessive proliferation and intimal migration of vascular smooth muscle cells (VSMCs) in the ...
Kaixu Wang, Daiyu Zhang, Yu Hu, Yixin Zhao, Xinling Wang, Long Jiang, Meixiu Jiang   +6 more
wiley   +1 more source

Phase 1 Study of Safety and PK With A Combination of Omeprazole and Trimetazidine for Fatty Acid Oxidation Inhibition in Patients With Advanced Solid Tumors

Clinical and Translational Science, Volume 19, Issue 11, November 2026.
ABSTRACT Fatty acid oxidation (FAO) is a metabolic vulnerability in cancer cells, making pharmacologic FAO inhibition a promising therapeutic strategy. This Phase I, open‐label, 3 + 3 dose‐escalation study evaluated the safety, tolerability, pharmacokinetics, and preliminary antitumor activity of two oral FAO inhibitors—omeprazole (KN510), a carnitine ...
Wonyoung Choi, Jung W. Chun, Sung H. Sim, Sung‐Sik Han, Woo J. Lee, Joon H. Kang, Hyun Chul Kim, SeungHwan Lee, Jun H. Lee, Hyun J. Yoo, Soo‐Youl Kim, Sang M. Woo   +11 more
wiley   +1 more source