Ambulatory intravenous insulin and islet cell transplantation to treat severe type III insulin hypersensitivity in a patient with type 1 diabetes mellitus [PDF]
Clinical Case Reports, 2020 Allogenic pancreatic islet cell transplantation is an appropriate treatment option to consider in the management of refractory cases of severe hypersensitivity to insulin in patients with type 1 diabetes mellitus.
Brigette Clarke +5 more
doaj +3 more sources
Insulin hypersensitivity induced by hepatic PTEN gene ablation protects from murine endotoxemia. [PDF]
PLoS ONE, 2013 Sepsis still remains a major cause for morbidity and mortality in patients. The molecular mechanisms underlying the disease are still enigmatic. A great number of therapeutic approaches have failed and treatment strategies are limited to date.
Philipp M Guenzl +5 more
doaj +3 more sources
Drosophila Insulin receptor regulates the persistence of injury-induced nociceptive sensitization [PDF]
Disease Models & Mechanisms, 2018 Diabetes-associated nociceptive hypersensitivity affects diabetic patients with hard-to-treat chronic pain. Because multiple tissues are affected by systemic alterations in insulin signaling, the functional locus of insulin signaling in diabetes ...
Seol Hee Im +3 more
doaj +3 more sources
The complexities of insulin allergy: a case and approach [PDF]
Allergy, Asthma & Clinical Immunology, 2021 Background Insulin hypersensitivity is rare, but challenging for individuals with diabetes. The prevalence of insulin allergy has decreased since the introduction of human recombinant insulin preparations.
Babak Aberumand, Samira Jeimy
doaj +2 more sources
Immediate and Late Onset Forms of Insulin Hypersensitivity Presenting with Glucose Dysregulation
Endocrinology Research and Practice, 2018 We report the case of a 35-year-old woman allergic to detemir, neutral protamine Hagedorn, and glargine. Initially, local reactions to the insulin preparations occurred, which continued even after the types of insulin and the application areas were ...
Ceyda TUNAKAN DALGIÇ +4 more
doaj +3 more sources
Delayed Hypersensitivity Reaction to Insulin: A Case Report [PDF]
CureusAdvances in the purification of animal insulin preparations and the introduction of recombinant human insulin have markedly reduced the frequency of insulin hypersensitivity reactions. However, preservatives such as metacresol and other excipients contained in insulin formulations may still induce hypersensitivity reactions, which may be immediate ...
Aharmim, Mohammed +3 more
openaire +3 more sources
Transient juvenile hypoglycemia in GH insensitive Laron syndrome pigs is associated with insulin hypersensitivity [PDF]
Molecular MetabolismBackground and aims: Fasting hypoglycemia has clinical implications for children with growth hormone (GH)-insensitivity syndrome. This study investigates the pathophysiology of juvenile hypoglycemia in a large animal model for GH receptor (GHR ...
Arne Hinrichs +21 more
doaj +2 more sources
ILP4 and InR regulate paclitaxel-induced hypersensitivity differently in Drosophila larvae [PDF]
Mol Biol CellPaclitaxel (PTX), a chemotherapeutic that stabilizes microtubules, induces nociceptive hypersensitivity and sensory neuron damage in humans, mice, and flies.
Srivastava, Yogesh +4 more
core +2 more sources
Successful rapid desensitization to multiple insulin preparations in an adult with type 1 diabetes: a case report and literature review [PDF]
Frontiers in EndocrinologyBackgroundInsulin allergy, although rare in type 1 diabetes (T1DM), poses a significant clinical challenge due to the indispensable role of insulin therapy.
Yuwen Chen +3 more
doaj +2 more sources
Journal of Family Medicine and Primary Care, 2020 Hypersensitivity reactions against exogenous insulin are a rare clinical entity after the advent of recombinant human insulin; however, there are still case reports wherein patients develop hypersensitivity reactions against insulin.
K U Lijesh +5 more
doaj +1 more source