Results 41 to 50 of about 90,099 (312)

Development and application of insulin infusion profiles for therapy of type I diabetics with portable insulin infusion systems

open access: yesLife support systems : the journal of the European Society for Artificial Organs, 1984
The metabolism of insuIin-dependent diabetics (lDDs) cannot always be normalized by the conventional subcutaneous insulin regimen that usually provides only two Injections of reguIar and intermediate-acting insulin per day, but glucose-controlled intravenous insuIin infusion ensures almost normal glycaemia all day long.
Schulz, Gerhard   +7 more
openaire   +4 more sources

Acute effects of elevated NEFA on vascular function: a comparison of SFA and MUFA [PDF]

open access: yes, 2010
There is emerging evidence to show that high levels of NEFA contribute to endothelial dysfunction and impaired insulin sensitivity. However, the impact of NEFA composition remains unclear.
Abby K. Thompson   +9 more
core   +1 more source

Effectiveness of Predicted Low-Glucose Suspend Pump Technology in the Prevention of Hypoglycemia in People with Type 1 Diabetes Mellitus: Real-World Data Using DIA:CONN G8 [PDF]

open access: yesDiabetes & Metabolism Journal
We evaluated the effectiveness of the predictive low-glucose suspend (PLGS) algorithm in the DIA:CONN G8. Forty people with type 1 diabetes mellitus (T1DM) who used a DIA:CONN G8 for at least 2 months with prior experience using pumps without and with ...
Jee Hee Yoo, Ji Yoon Kim, Jae Hyeon Kim
doaj   +1 more source

Optimal Regulation of Blood Glucose Level in Type I Diabetes using Insulin and Glucagon

open access: yes, 2019
The Glucose-Insulin-Glucagon nonlinear model [1-4] accurately describes how the body responds to exogenously supplied insulin and glucagon in patients affected by Type I diabetes.
Della Rossa, Fabio   +4 more
core   +4 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Back stepping-Based-PID-Controller Designed for an Artificial Pancreas model

open access: yesAl-Khawarizmi Engineering Journal, 2011
Artificial pancreas is simulated to handle Type I diabetic patients under intensive care by automatically controlling the insulin infusion rate. A Backstepping technique is used to apply the effect of PID controller to blood glucose level since there is ...
Taghreed M. Mohammad Ridha   +2 more
doaj   +2 more sources

Emerging Nano- and Micro-Technologies Used in the Treatment of Type-1 Diabetes

open access: yesNanomaterials, 2020
Type-1 diabetes is characterized by high blood glucose levels due to a failure of insulin secretion from beta cells within pancreatic islets. Current treatment strategies consist of multiple, daily injections of insulin or transplantation of either the ...
Rosita Primavera   +6 more
doaj   +1 more source

Characterizing social and policy determinants of hospital length of stay among paediatric inpatients with diabetes using linked population-based data

open access: yesInternational Journal of Population Data Science, 2021
Background Evidence is limited on the non-medical factors influencing hospital length of stay (LOS) among paediatric inpatients with diabetes, notably potential social and policy correlates.
Heather Higgins, Neeru Gupta
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

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