Results 51 to 60 of about 9,494,626 (300)

Intravenous insulin infusion system to determine insulin regimen in diabetics.

The Tohoku Journal of Experimental Medicine, 1988
An algorithm for insulin infusion system to control blood glucose was derived from results of intravenous (i.v.) insulin infusion performed on 10 diabetics. I.v. insulin infusion was done on 14 diabetics for 24 hr using the algorithm, and blood glucose was controlled within the proper range in all cases; mean blood glucose was 130 +/- 42 mg/100 ml ...
ITO, MASAAKI, SATO, TOKUTARO, SAITO, TUYOSHI, KOKUBUN, MASARU, INOUE, MICHIKO, SAITO, KAZUKO, YOSHINAGA, KAORU   +6 more
openaire   +3 more sources

Continuous Glucose Monitoring Sensors for Diabetes Management: A Review of Technologies and Applications [PDF]

Diabetes & Metabolism Journal, 2019
By providing blood glucose (BG) concentration measurements in an almost continuous-time fashion for several consecutive days, wearable minimally-invasive continuous glucose monitoring (CGM) sensors are revolutionizing diabetes management, and are ...
Giacomo Cappon, Martina Vettoretti, Giovanni Sparacino, Andrea Facchinetti   +3 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Insulin therapy and dietary adjustments to normalize glycemia and prevent nocturnal hypoglycemia after evening exercise in type 1 diabetes: a randomized controlled trial [PDF]

, 2015
Introduction Evening-time exercise is a frequent cause of severe hypoglycemia in type 1 diabetes, fear of which deters participation in regular exercise.
Gonzalez, JT, Walker, Mark, Stevenson, Emma, Gonzalez, Javier T, Campbell, Matthew, Turner, David, Richard Bracken, Bracken, Richard M, Bracken, Richard, Shaw, James, Shaw, JA, West, Daniel J, Walker, M, Bracken, RM, Turner, Daniel, Stevenson, Emma J, Stevenson, EJ, Gonzalez, Javier, Campbell, MD, West, DJ, Turner, D, Shaw, James A, West, Dan   +22 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Estimation of insulin sensitivity from continuous glucose monitoring and insulin pump data in type 1 diabetes [PDF]

, 2012
Diabetes mellitus is a disease characterized by chronic hyperglycemia either due to a lack of secretion of the hormone insulin (Type 1 Diabetes Mellitus, T1DM) or due to impaired action of this hormone (Type 2 Diabetes Mellitus, T2DM).
Ronca, Gabriele
core  

Effect of the dietary fat quality on insulin sensitivity. [PDF]

, 2008
Recent evidence shows that specific fatty acids affect cell metabolism, modifying the balance between fatty acid oxidation and lipogenesis. These effects may have important implications in addressing the present epidemic of nutrition-related chronic ...
Aguirre, Carolina A, Uauy Dagach-Imbarack, Ricardo, Galgani Fuentes, José, Díaz Bustos, Erik, Aguirre, Carolina A., Galgani, José E, Uauy, Ricardo D, Díaz, Erik O   +7 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Type 1 diabetes control and pregnancy outcomes in women treated with continuous subcutaneous insulin infusion (CSII) or with insulin glargine and multiple daily injections of rapid-acting insulin analogues (glargine-MDI).

, 2011
AIM: The best way to treat pregnant patients who have type 1 diabetes is still unclear. For this reason, the present study compared metabolic control and maternal-fetal outcomes in patients treated with continuous subcutaneous infusions of rapid-acting ...
Di Cianni G, BRUTTOMESSO, DANIELA, Dal Pos M, Vitacolonna E, Pellicano F, Torlone E, Costa S, Di Benedetto A, LAPOLLA, ANNUNZIATA, Italian Group for Continuous Subcutaneous Insulin Infusion in Pregnancy, Dodesini AR, Tonutti L, Bonomo M   +12 more
core   +1 more source