Results 41 to 50 of about 87,132 (309)

Characterizing social and policy determinants of hospital length of stay among paediatric inpatients with diabetes using linked population-based data

International Journal of Population Data Science, 2021
Background Evidence is limited on the non-medical factors influencing hospital length of stay (LOS) among paediatric inpatients with diabetes, notably potential social and policy correlates.
Heather Higgins, Neeru Gupta
doaj   +1 more source

Lower cerebrospinal fluid/plasma fibroblast growth factor 21 (FGF21) ratios and placental FGF21 production in gestational diabetes [PDF]

, 2013
Objectives: Circulating Fibroblast Growth Factor 21 (FGF21) levels are increased in insulin resistant states such as obesity, type 2 diabetes mellitus and gestational diabetes mellitus (GDM). In addition, GDM is associated with serious maternal and fetal
A Kharitonenkov, AN Pathmaperuma, Bee K. Tan, BK Tan, C Gälman, CA Crowther, CM Simán, DA Sarruf, DR Matthews, H Hsuchou, Harpal S. Randeva, HM Salihu, J Chen, K Baptiste-Roberts, K Li, K Mørkrid, Kavitha Sivakumar, KV Smirnakis, L Li, M Lappas, Manu Vatish, MM Agarwal, Muhammad F. Bari, NF Butte, PJ Enriori, PM Catalano, SY Chu, SY Nam, T Coskun, T Yamashita, Victor Sanchez-Margalet, X Zhang, Z Lin   +32 more
core   +2 more sources

Polyvinyl chloride-related insulin adsorption in critical care: a narrative review with implications for patient safety and green hospital reform

Frontiers in Medicine
IntroductionInsulin infusion therapy is critical for glycemic management in intensive care units (ICUs), yet its effectiveness is compromised by adsorption to infusion materials, particularly polyvinyl chloride (PVC) tubing and bags plasticized with di(2-
Selwan Hamza Elgazzar, Rasha Kadri Ibrahim, Yasmin Moustafa Ayoub, Raeed Alanazi, Abdulaziz K. Alanazi, Hyam Refaat Tantawi, Ahmad R. Al-Qudimat, Ahmad R. Al-Qudimat, Ashwag Alsharidah, Abdelaziz Hendy, Abdelaziz Hendy   +10 more
doaj   +1 more source

NEW INFUSERS

Revista de la Sociedad Argentina de Diabetes, 2020
Accompanying the great technological revolution of recent years, insulin infusers have been no exception. From their origins, in just over 50 years, these teams, which changed the lives of many people with diabetes and their families, have experienced ...
Alejandro Daín
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Emerging Nano- and Micro-Technologies Used in the Treatment of Type-1 Diabetes

Nanomaterials, 2020
Type-1 diabetes is characterized by high blood glucose levels due to a failure of insulin secretion from beta cells within pancreatic islets. Current treatment strategies consist of multiple, daily injections of insulin or transplantation of either the ...
Rosita Primavera, Bhavesh D Kevadiya, Ganesh Swaminathan, Rudilyn Joyce Wilson, Angelo De Pascale, Paolo Decuzzi, Avnesh S Thakor   +6 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Digestion, rumen fermentation and circulating concentrations of insulin, growth hormone and IGF-1 in steers fed diets based on different proportions of maize silage and grass silage [PDF]

, 2008
Replacing grass silage with maize silage results in a fundamental change in the ratio of structural to non-structural carbohydrates with commensurate changes in rumen fermentation patterns and nutrient utilisation.
Beever, Brier, Browne, Cone, D.E. Beever, D.T. Juniper, DePeters, Downes, E.M. Browne, Echternkamp, Elizalde, Elsasser, Friggens, Hart, Juniper, Juniper, Kung, M.J. Bryant, MacRae, Merriam, Mertens, Mould, Overton, Reynolds, Robinson, Steen, Steen, Sutton, Sutton, Theurer, Thorp   +30 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source