Results 61 to 70 of about 39,968 (304)

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

open access: yesFEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar   +4 more
wiley   +1 more source

Insulin delivery devices in diabetes management: Applications and advancements

open access: yesIntelligent Pharmacy
With continuous advancements in diabetes management technology, insulin delivery devices have become increasingly central to the treatment of diabetes.
Runhuang Yang   +3 more
doaj   +1 more source

New Design of a Percutaneous Port System for Continuous Intraperitoneal Insulin Infusion [PDF]

open access: yesJournal of Diabetes Science and Technology, 2019
Insulin-dependent diabetes mellitus is treated with intensive insulin therapy using multiple daily injections or continuous subcutaneous insulin infusion with insulin pumps. For people with diabetes who cannot achieve acceptable glycemic control despite the use of intensive insulin therapy and continuous glucose measurement, there exists the ...
Cosima Rieger   +4 more
openaire   +2 more sources

Evaluation of glucose tolerance test and surrogate indexes of insulin sensitivity to detect insulin resistance syndrome in transition dairy cows [PDF]

open access: yes, 2013
Healthy multiparous Holstein-Fresian cows (n=101, parity ≥ 2) from 3 large-scale dairy herds in Italy were subjected to an intravenous glucose tolerance test (GTT) 14-1 d before (Week -1) and 3-9 d after calving (Week +1).
Riuzzi, Sara
core  

Assessment of gelling in insulin solutions for infusion pumps

open access: yes, 1985
Prolonged, gentle agitation of U100 insulin solutions containing various ingredients has shown that gelling can take place. The extent of gelling was evaluated by low shear rheometry and quantified in terms of the effective molecular weight increase ...
K G Hutchison
core   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

open access: yesFEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta   +7 more
wiley   +1 more source

Optimized type-2 fuzzy controller based on IoMT for stabilizing the glucose level in type-1 diabetic patients

open access: yesScientific Reports, 2023
Due to advancements in existing Internet of Medical Things (IoMT) systems and devices, the blood glucose level (BGL) for type-1 diabetic patients (T1DPs) is effectively and continually monitored and controlled by Artificial Pancreas.
Amged Sayed   +3 more
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

open access: yesFEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

open access: yesFEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo   +6 more
wiley   +1 more source

Simulating Insulin Infusion Pump Risks by In-Silico Modeling of the Insulin-Glucose Regulatory System [PDF]

open access: yes, 2012
We present a case study on the use of robustness-guided and statistical model checking approaches for simulating risks due to insulin infusion pump usage by diabetic patients. Insulin infusion pumps allow for a continuous delivery of insulin with varying rates and delivery profiles to help patients self-regulate their blood glucose levels. However, the
Sriram Sankaranarayanan 0001   +1 more
openaire   +1 more source

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