Results 61 to 70 of about 9,494,626 (300)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Carbohydrate and lipid metabolism in insulin resistant states and the development of in vivo magnetic resonance spectroscopic techniques for the analysis of gluconeogenesis and glycogen synthesis [PDF]

, 1995
PhDThis thesis will provide new information on carbohydrate and lipid metabolic control in various related physiological states both in vitro and in vivo in the rat model.
Changani, K.K., Changani, Kishore Kumar
core   +4 more sources

The modification of insulin to enhance oral delivery systems [PDF]

, 2009
textWhile a number of PEGylated proteins have been studied for injectable applications and reviewers have used this data to speculate possible oral delivery improvements, a detailed investigation of PEGylated insulin for oral delivery and the development
Kanzelberger, Melissa Ann
core  

Contribution of liver nerves, glucagon, and adrenaline to the glycaemic response to exercise in rats [PDF]

, 1994
The contribution of hepatic sympathetic innervation, glucagon and adrenaline to the glycaemic response to exercise was investigated in rats. Hepatically denervated (LDX) or sham operated (SHAM) rats with permanent catheters were therefore submitted to ...
B. AHRÉN, Dijk, G. van,, Bouws, G., van Dijk, Gertjan; id_orcid, Ahrén, B., Lindfeldt, J., KUVAKİ BALKAN, BAHAR, Bouws, G.,, SCHEURINK, AJW, AHREN, B, Balkan, B.,, Balkan, B., A. J. W. SCHEURINK, VAN DIJK, G, BOUWS, G, LINDFELDT, J, Scheurink, A.J.W., BALKAN, B, STEFFENS, AB, G. BOUWS, Steffens, A.B.,, B. BALKAN, Ahrén, B.,, Scheurink, A.J.W.,, A. B. STEFFENS, Steffens, A.B., Lindfeldt, J.,, G. VAN DIJK, van Dijk, Gertjan, VANDIJK, G, J. LINDFELDT   +30 more
core   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Back stepping-Based-PID-Controller Designed for an Artificial Pancreas model

Al-Khawarizmi Engineering Journal, 2011
Artificial pancreas is simulated to handle Type I diabetic patients under intensive care by automatically controlling the insulin infusion rate. A Backstepping technique is used to apply the effect of PID controller to blood glucose level since there is ...
Taghreed M. Mohammad Ridha, Mina Qais Kadhum, Shaima Mahmou Mahdi   +2 more
doaj   +2 more sources

NEW INFUSERS

Revista de la Sociedad Argentina de Diabetes, 2020
Accompanying the great technological revolution of recent years, insulin infusers have been no exception. From their origins, in just over 50 years, these teams, which changed the lives of many people with diabetes and their families, have experienced ...
Alejandro Daín
doaj   +1 more source

Current Technologies for Managing Type 1 Diabetes Mellitus and Their Impact on Quality of Life—A Narrative Review

Life, 2023
Type 1 diabetes mellitus is a chronic autoimmune disease that affects millions of people and generates high healthcare costs due to frequent complications when inappropriately managed.
Viviana Elian, Violeta Popovici, Emma-Adriana Ozon, Adina Magdalena Musuc, Ancuța Cătălina Fița, Emilia Rusu, Gabriela Radulian, Dumitru Lupuliasa   +7 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Continuous intraperitoneal insulin infusion as a valuable approach in patients with unstable type 1 diabetes: two case reports and a mini review of the literature

Frontiers in Medicine
In recent years, continuous intraperitoneal insulin infusion (CIPII) has become a valid therapeutic option to achieve good glycemic control for patients with unstable type 1 diabetes and subcutaneous insulin resistance, mainly due to the absorption of ...
Erika Pedone, Amelia Caretto, Giulio Belfiori, Anna Zanardini, Sergio Di Molfetta, Luigi Laviola, Francesco Giorgino, Lorenzo Piemonti, Lorenzo Piemonti, Lorenzo Piemonti, Marina Scavini, Andrea Laurenzi, Andrea Laurenzi   +12 more
doaj   +1 more source