Results 111 to 120 of about 502,774 (317)

Transfer Printing and Reconfiguration of Soft Electronics Using Digital Microfluidics and Laser Machining

Advanced Functional Materials, EarlyView.
This paper presents a digital microfluidics‐based technique for transferring and reconfiguring soft nanomembranes. Laser‐machined nanothin membranes are picked up, transported, and aligned via tailored surface tension and the actuation of water droplets, enabling the development of flexible electronics, the integration of functional materials on 3D ...
Quang Anh Nguyen, Chi Cong Nguyen, Tran Bach Dang, Phuoc Thien Phan, Jordan Thorpe, Michael Listyawan, Nhat Minh Doan, Sinuo Zhao, Hongru Chen, Trung Thien Hoang, Mingsheng Xu, Jisheng Han, Thanh Nho Do, Adam Hill, Timothée Mouterde, Hoang‐Phuong Phan   +15 more
wiley   +1 more source

The GOAT-ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restriction. [PDF]

, 2012
Ghrelin acylation by ghrelin O-acyltransferase (GOAT) has recently been reported to be essential for the prevention of hypoglycemia during prolonged negative energy balance.
Bidlingmaier, Martin, Stephen C Benoit, Kristy M. Heppner (182036), Tong, J., Pfluger, Paul T., Zhao, Y., Bidlingmaier, M., Davis, Harold W., Chun-Xia Yi (182031), Kirchner, H., Erin Bartley (182062), Tong, Jenny, Tschöp, Matthias H., Bartley, Erin, Kruthaupt Traci, Gaylinn, B.D., Kirchner, Henriette, Matthias H. Tschöp (158357), Kirk M Habegger, Yongmei Zhao (182070), Kabra, D.G., Bruce D Gaylinn, Timo D. Müller (103425), Stephen C. Benoit (179150), Heppner, K.M., Joseph Anupama, Heppner, Kristy M., Kabra, Dhiraj, Davis, H.W., Yi, Chun-Xia, Traci Kruthaupt (182079), Kristy M Heppner, Joseph, A., Habegger Kirk M., Ottaway, N., Benoit, S.C., Harold W. Davis (182066), Ottaway Nickki, Zhao Yongmei, Nickki Ottaway, Yi, C.-X., Bielohuby Maximillian, Joseph, Anupama, Müller, T.D., Jenny Tong (182043), Kruthaupt, Traci, Yi Chun-Xia, Perez-Tilve Diego, Yongmei Zhao, Maximillian Bielohuby (182048), Müller, Timo D., Davis Harold W., Kirk M. Habegger (182097), Tschöp Matthias H., Anupama Joseph (182074), Dhiraj Kabra (182091), Bidlingmaier Martin, Bartley, E., Thorner, Michael O., Maximillian Bielohuby, Harold W Davis, Nickki Ottaway (182086), Anupama Joseph, Matthias H Tschöp, Benoit, Stephen C., Diego Perez-Tilve, Gaylinn Bruce D., Müller Timo D., Dhiraj Kabra, Kirchner Henriette, Jenny Tong, Traci Kruthaupt, Gaylinn, Bruce D., Paul T Pfluger, Perez-Tilve, Diego, Michael O Thorner, Diego Perez-Tilve (182114), Zhao, Yongmei, Thorner Michael O., Bielohuby, M., Tschöp, M.H., Henriette Kirchner (182039), Kabra Dhiraj, Timo D Müller, Bartley Erin, Habegger, K.M., Bielohuby, Maximilian, Michael O. Thorner (182107), Paul T. Pfluger (179123), Martin Bidlingmaier (150187), Pfluger Paul T., Bruce D. Gaylinn (182057), Chun-Xia Yi, Martin Bidlingmaier, Habegger, Kirk M, Henriette Kirchner, Pfluger, P.T., Benoit Stephen C., Kruthaupt, T., Heppner Kristy M., Erin Bartley, Tong Jenny, Ottaway, Nickki, Perez-Tilve, D., Thorner, M.O.   +104 more
core   +1 more source

A high-fructose diet induces changes in pp185 phosphorylation in muscle and liver of rats

Brazilian Journal of Medical and Biological Research, 2000
Insulin stimulates the tyrosine kinase activity of its receptor resulting in the tyrosine phosphorylation of pp185, which contains insulin receptor substrates IRS-1 and IRS-2. These early steps in insulin action are essential for the metabolic effects of
M. Ueno, R.M.N. Bezerra, M.S. Silva, D.Q. Tavares, C.R. Carvalho, M.J.A. Saad   +5 more
doaj   +1 more source

Microfabricated Anisotropic Myobundles for the Scalable Production of Cardiac Tissue Grafts

Advanced Functional Materials, EarlyView.
Controlling the anisotropy of cardiac tissue remains an outstanding challenge in the field of cardiac tissue engineering. Here, we introduce an approach to generate anisotropic cardiac myobundles using cell‐adhesive, synthetic, electrospun fibers and stem cell‐derived cardiac fibroblasts.
Maggie E. Jewett, Javiera Jilberto, Margaret E. Stanley, David O. Ntim, Siddhi M. Bhirud, Avianna T. Schroeder, Gonzola X. Anyosa Galvez, Jingyi Xia, Samuel J. DePalma, Emmanouil Agrafiotis, Susan S. Xi, Amanda S. Bluem, Courtney M. Lestock, Adam S. Helms, David A. Nordsletten, Brendon M. Baker   +15 more
wiley   +1 more source

Inflammation, insulin resistance, and diabetes : mendelian randomization using CRP haplotypes points upstream [PDF]

, 2008
Background Raised C-reactive protein (CRP) is a risk factor for type 2 diabetes. According to the Mendelian randomization method, the association is likely to be causal if genetic variants that affect CRP level are associated with markers of diabetes ...
Timpson, NJ, Daniel R Witte, Kumari, Meena, Brunner, Eric J, Nicholas J Timpson, Witte Daniel R, Shah Tina, Kumari, M., Michelle Miller, Smith George Davey, Smith, GD, Humphries, SE, Smith, G.D., Aroon D Hingorani, Hingorani, AD, Marmot, MG, Rumley, A., Ann Rumley, Kumari Meena, Meena Kumari, Steve E Humphries, Michael G Marmot, Kumari, M, Witte, Daniel R, Shah, T, Casas, Juan P., Miller, M., Lowe, G.D., Marmot, Michael G, Juan P Casas, Rumley, Ann, Smith, George Davey, Shah, Tina, Humphries, S.E., Witte, DR, Gordon D O Lowe, Brunner Eric J, Lawlor, DA, Cooper Jackie A, Humphries Steve E, Cooper, J.A., Brunner, Eric, Hingorani, Aroon D, Marmot Michael G, Cooper, Jackie A., Miller, Michelle A., Lawlor, D.A., Witte, D.R., Timpson, Nicholas J., Lowe, GDO, Kivimäki, Mika, Casas Juan P, Mika Kivimäki, Cooper, Jackie A, Witte, Daniel R., Kivimaki, M., Kivimäki Mika, Miller, Michelle, Lawlor, Debbie A, Lowe, Gordon DO, Hingorani, A.D., Marmot, M.G., Humphries, Steve E, Tina Shah, Marmot, Michael G., Davey Smith, G, Lowe Gordon D. O, Brunner, EJ, Lowe, GD, Hingorani Aroon D, Cooper, JM, Lowe, G. D. O., Timpson, Nicholas J, Timpson Nicholas J, Brunner, E.J., Kivimaki, MJ, Lawlor, D, Casas, Juan P, Lawlor, Debbie A., Cooper, JA, Miller, M, Kivimaki, M, Eric J Brunner, Jackie A Cooper, Timpson, N.J., Debbie A Lawlor, Miller Michelle, Shah, T., Casas, JP, George Davey Smith, Rumley Ann, Casas, J.P., Rumley, A, Lawlor Debbie A, Humphries, Steve E., Hingorani, Aroon   +95 more
core   +1 more source

Functional Precision Oncology Approach Using Nanoliter Droplet Array for Drug Sensitivity Testing in Lung Cancer

Advanced Healthcare Materials, EarlyView.
A miniaturized drug sensitivity and resistance testing (DSRT) workflow based on the Droplet Microarray (DMA) platform enables functional drug testing using minimal patient‐derived tumor material. By screening nanoliter‐scale droplets containing as few as 300 cells, this approach generates reproducible and tumor‐specific drug response profiles ...
Maryam Salarian, Vicky L. Schiling, Thomas Muley, Michael Allgäuer, Florian Eichhorn, Michael Meister, Marc A. Schneider, Anna A. Popova   +7 more
wiley   +1 more source

Investigation of the binding interactions between insulin and its receptor

, 2015
This project investigated the interactions between insulin and its receptor. A combination of computational and experimental investigations resulted in the identification of four residues in non-canonical sites that, when mutated, had detrimental effects
Sit, Kei Chun
core  

MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels

Nature Communications, 2016
Insulin receptor levels at the cell surface are reduced in insulin resistance, for reasons that are not fully understood. Here, the authors identify the E3 ubiquitin ligase MARCH1 as a direct regulator of basal insulin receptor surface levels and ...
Arvindhan Nagarajan, Max C. Petersen, Ali R. Nasiri, Gina Butrico, Annie Fung, Hai-Bin Ruan, Romy Kursawe, Sonia Caprio, Jacques Thibodeau, Marie-Claude Bourgeois-Daigneault, Lisha Sun, Guangping Gao, Sanjay Bhanot, Michael J. Jurczak, Michael R. Green, Gerald I. Shulman, Narendra Wajapeyee   +16 more
doaj   +1 more source

Coaxially Electrospun Myocardial dECM‐ Based Nanofibrous Scaffolds Demonstrate Enhanced Cardiomyocyte Biocompatibility

Advanced Healthcare Materials, EarlyView.
Our coaxial electrospinning system is capable of incorporating decellularized myocardial extracellular matrix in a core‐sheath configuration, creating nanofibrous scaffolds. These scaffolds, in turn, support the maintenance of functional cardiomyocytes adhered to the surface of these bioactive scaffolds.
Dhanusha N. Rajapakse, Mahtab Khodadadi, Kiran M. Ali, Suh Hee Cook, Bryson T. Proctor, Tanya Upadhyay, Daxian Zha, Fatema Tuj Jahura, Marziyeh Boosaliki, Jessica M. Gluck   +9 more
wiley   +1 more source

The modification of insulin to enhance oral delivery systems

, 2009
textWhile a number of PEGylated proteins have been studied for injectable applications and reviewers have used this data to speculate possible oral delivery improvements, a detailed investigation of PEGylated insulin for oral delivery and the development
Kanzelberger, Melissa Ann
core