Results 111 to 120 of about 2,068,287 (293)
MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels
Nature Communications, 2016 Insulin receptor levels at the cell surface are reduced in insulin resistance, for reasons that are not fully understood. Here, the authors identify the E3 ubiquitin ligase MARCH1 as a direct regulator of basal insulin receptor surface levels and ...
Arvindhan Nagarajan +16 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave +8 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.A spatially controlled embedded bioprinting strategy enables precise engineering of prevascularized multicellular spheroids within skin‐derived dECM bioinks. Optimized spheroid size, composition, and spacing promote vascular maturation, paracrine signaling, and tissue integration, resulting in enhanced angiogenesis, blood perfusion, and functional skin
Minjun Ahn +6 more
wiley +1 more source
Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development
Advanced Healthcare Materials, EarlyView.LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans +7 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu +10 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Self‐healing assembly of two cell‐laden hydrogel layers creates a biomimetic skin construct that restores both dermal and epidermal functions, resulting in accelerated wound healing and enhanced hair follicle regeneration in a full‐thickness skin wound model. ABSTRACT Alopecia remains a pervasive clinical challenge, largely owing to the limited ability
JaeWook Park +5 more
wiley +1 more source
Biointegrated Battery‐Based Electroceuticals
Advanced Materials, EarlyView.Biointegrated batteries go beyond passive power to serve as active therapeutic platforms for delivering programmable electrical cues and bioactive agents. This review examines their mechanisms and applications and provides a framework to guide battery‐based therapeutic design and clinical translation.
Yan Zhou +6 more
wiley +1 more source
Advanced Materials, EarlyView.Spatiotemporal control over cell behavior within bioprinted constructs remains a key challenge in biofabrication. Volumetric bioprinting using multi‐wavelength light sources permits to activate light‐sensitive intracellular proteins as well as optogenetic gene and protein expression circuits in bioprinted cells, in addition to enabling fast printing of
Davide Ribezzi +14 more
wiley +1 more source
Insulin and insulin receptor abnormality.
Nihon Naika Gakkai Zasshi, 1993 インスリンあるいはインスリン受容体の異常が糖尿病者で見い出された.インスリン受容体に結合しえない異常インスリンやプロインスリンが産生されるインスリン遺伝子の異常,細胞表面のインスリン受容体の数や機能が減少するインスリン受容体遺伝子の異常あるいはインスリン受容体に対する自己抗体の存在が報告されている.いずれも高インスリン血症の存在が診断への手掛りとなるが,インスリンの異常ではインスリン抵抗性は存在しないがインスリン受容体の異常では存在する点が最大の鑑別点となる.インスリン遺伝子あるいはインスリン受容体遺伝子の異常が見い出された家系について検討すると,糖尿病の発症年齢,重症度は均一でなく,その発症には他の遺伝子異常あるいは環境要因の関与も推定され,糖尿病の発症にはいくつかの因子が関与していると考えられた.
openaire +2 more sources
Advanced Materials for Biologics Delivery to Brain Tumors
Advanced Materials, EarlyView.Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng +4 more
wiley +1 more source