Results 151 to 160 of about 794,012 (351)

Physiological and pathophysiological actions of insulin in the liver

Endocrine Journal
The liver plays an important role in the control of glucose homeostasis. When insulin levels are low, such as in the fasting state, gluconeogenesis and glycogenolysis are stimulated to maintain the blood glucose levels.
Naoto Kubota, Tetsuya Kubota, Takashi Kadowaki   +2 more
doaj   +1 more source

Insulin receptor tyrosine kinase substrate links theE. coliO157:H7 actin assembly effectors Tir and EspF_Uduring pedestal formation

, 2009
Didier Vingadassalom, Arūnas Kazlauskas, Brian Skehan, Hui‐Chun Cheng, Loranne Magoun, Douglas R. Robbins, Michael K. Rosen, Kalle Saksela, John M. Leong   +8 more
openalex   +1 more source

Supplementary Table S2 from Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose uptake [PDF]

, 2023
Yonglei Shang, Yifan Mao, Jennifer Batson, Suzie J. Scales, Gail D. Lewis Phillips, Mark R. Lackner, Klára Tótpál, Simon Williams, Jihong Yang, Tang Zhijun, Zora Modrušan, Christine Tan, Wei‐Ching Liang, Siao Ping Tsai, Alexander Vanderbilt, Kenji Kozuka, Klaus P. Hoeflich, Janet Tien, Sarajane Ross, Congfen Li, Sang Hoon Lee, An Song, Yan Wu, Jean-Philippe Stéphan, Avi Ashkenazi, Jiping Zha   +25 more
openalex   +1 more source

A New 3D Colon on a Chip to Decipher the Influence of Mechanical Forces on the Physiological Cellular Ecosystem

Advanced Healthcare Materials, EarlyView.
To dissect how mechanical forces influence intestinal physiology, we developed a stretchable 3D colon‐on‐chip that integrates tunable topography, stiffness and peristalsis‐like motion within a physiologically relevant microenvironment. We showed that stretching is a dominant factor governing epithelial behavior, markedly enhancing proliferation and ...
Moencopi Bernheim‐Dennery, Lauriane Gérémie, Julie Brun, Lucas Chassatte, Giacomo Gropplero, Réda Bouras, Jieun Choo, Bertrand Cinquin, Alba Marcellan, Danijela Matic Vignjevic, Stéphanie Descroix   +10 more
wiley   +1 more source

Bidirectional Crosstalk between Leptin and Insulin-like Growth Factor-I Signaling Promotes Invasion and Migration of Breast Cancer Cells via Transactivation of Epidermal Growth Factor Receptor [PDF]

, 2008
Neeraj K. Saxena, Meena M. Balgopal, Brandi B. Knight, Didier Merlin, Frank A. Anania, Ruth O’Regan, Dipali Sharma   +6 more
openalex   +1 more source

Supplementary Figure 4 from Combination of Two Insulin-Like Growth Factor-I Receptor Inhibitory Antibodies Targeting Distinct Epitopes Leads to an Enhanced Antitumor Response [PDF]

, 2023
Jianying Dong, Stephen J. Demarest, Arlene Sereno, Susan Tamraz, Emma Langley, Adam Doern, Tracey Snipas, Keli Perron, Ingrid B.J. Joseph, Scott Glaser, Steffan N. Ho, Mitchell E. Reff, Kandasamy Hariharan   +12 more
openalex   +1 more source

Zinc‐Containing Bioactive Glass Programs Macrophage Polarization through Extracellular Traps Regulation for Enhanced Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Zinc‐containing bioactive glass (ZnBG) promotes diabetic wound healing by regulating macrophage extracellular traps (METs). Specifically, ZnBG reduces oxidative stress and inhibits the PAD4 and NLRP3/caspase‐1/GSDMD signaling pathways, thereby suppressing MET formation.
RuiYang Sun, XueBo Wei, ZhuoYang Song, JunJun Luo, JingYi Ye, YinNan Zhang, LiFei Zhu, Jie Gao, Hongyu Zhang, Hong Zhu, Xin Wang, Ke Xu   +11 more
wiley   +1 more source

LDI, A Lipid Droplet Inhibitor, Disrupts Lipid Accumulation and Modulates Hepatic Lipid Profiles in Fatty Liver

Advanced Materials, EarlyView.
The lipid droplet inhibitor (LDI), templated with large‐pore mesoporous silica and functionalized with PKCα C1A and lipase, targets lipid degradation in fatty liver. The LDI maintains stable association with lipid droplets, thereby suppressing their formation and expansion.
Seunghee Kim, Yeojin Kim, Sanjita Paudel, In Young Kang, Suyeon Kim, Jeesoo Kim, Sunmi Park, Seung‐Hoi Koo, Hyun Sung Kim, Dae Won Jun, Jinyoung Park, Hyunbeom Lee, Joonseok Lee   +12 more
wiley   +1 more source

Computational Analysis of Genomic Regions of Human Insulin Receptor Gene

, 2016
Shahid Raza, Hira Mubeen
openalex   +1 more source

The Space Within: How Architected Voids Promote Tissue Formation

Advanced Materials, EarlyView.
This review explores the role of void spaces in tissue engineering scaffolds and examines four key methods for introducing porosity into hydrogels at different scales. It discusses sacrificial templating, microgels, phase separation, and 3D printing, highlighting principles, advantages, and limitations. It also addresses emerging strategies integrating
Anna Puiggalí‐Jou, Isabel B. Hui, Carla Fernandez‐Rico, Marcy Zenobi‐Wong   +3 more
wiley   +1 more source