Results 221 to 230 of about 2,068,287 (293)

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

The signaling adaptor insulin receptor substrate 2 (IRS2) limits lethal host responses induced by influenza infection. [PDF]

Innate Immun
Prantner D, Qi X, Villaneuva LM, Paton J, Blanco JCG, Vogel SN, Keegan AD, Shirey KA.   +7 more
europepmc   +1 more source

ROS‐Responsive Eye Drop for Controlled Release of 20‐Deoxyingenol Improves Diabetic Corneal Healing by Activating Macrophage Autophagy and Metabolic Reprogramming

Advanced Science, EarlyView.
Schematic illustration of ROS‐responsive TSPBA‐PVA microspheres loaded with 20‐deoxyingenol (TP/20‐DOI) for diabetic corneal wound healing: (a) fabrication and ROS‐triggered release; (b) autophagy activation and metabolic reprogramming in macrophages; (c) suppression of macrophage‐derived CXCL3/CXCL5, attenuation of neutrophil infiltration, and ...
Jiaxin Wu, Wanying Chen, Haijiang Qiu, Weihan Zheng, Ying Jiao, Jingheng Du, Zhudan Zhuang, Xing Hua, Jingyi Gu, Yuheng Liu, Zhaojin Li, Jingbin Xie, Hanxiao Sun, Huifei Lan, Xin Sun, Yunxia Xue, Ting Fu, Zhijie Li, Guobing Chen, Shiyu Li, Jun Liu   +20 more
wiley   +1 more source

Multiscale Computational Protocols for Accurate Residue Interactions at the Flexible Insulin-Receptor Interface. [PDF]

J Chem Inf Model
Yurenko YP, Muždalo A, Černeková M, Pecina A, Řezáč J, Fanfrlík J, Žáková L, Jiráček J, Lepšík M.   +8 more
europepmc   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Longitudinal Study of the Influence of Periodontal Treatment on the Levels of Insulin Receptor Substrate-2 and Superoxide Dismutase 1 in Individuals with Type 2 Diabetes Mellitus. [PDF]

Biomedicines
Caldeira FID, Silva RCL, Martelli MGG, Nicchio IG, Orrico SRP, Cirelli JA, Sasso Cerri E, Cerri PS, Manzolli Leite FR, Scarel-Caminaga RM.   +9 more
europepmc   +1 more source

Corrigendum to "Insulin receptor-mediated signaling regulates pluripotency markers and lineage differentiation" [Mol Metab 18 (2018) 153-163]. [PDF]

Mol Metab
Gupta MK, De Jesus DF, Kahraman S, Valdez IA, Shamsi F, Yi L, Swensen AC, Tseng YH, Qian WJ, Kulkarni RN.   +9 more
europepmc   +1 more source

Heat shock protein DNAJA2 controls insulin signaling and glucose homeostasis by preventing spontaneous insulin receptor endocytosis. [PDF]

Nat Commun
Qin Y, Wu W, Lin K, Davis AJ, Huang Y.
europepmc   +1 more source

Correlation between insulin receptor expression and tumor cell proliferation, recurrence and metastasis in well-differentiated pancreatic neuroendocrine neoplasms. [PDF]

Endocr Connect
Deng X, Niu T, Zheng M, Li J, Mao X, Chen D, Tang L, Liang X, Yang G, Ji M, Shi L, Wu W, Hu L, Lv X, Wang X, Shao C.   +15 more
europepmc   +1 more source

Identifying antisense oligonucleotides for targeted inhibition of insulin receptor isoform A. [PDF]

Front Oncol
Galifi CA, Dikdan RJ, Kantak D, Bulatowicz JJ, Maingrette K, Gunderson SI, Wood TL.   +6 more
europepmc   +1 more source