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Novel Function for Endothelial Protease-Activated Receptors in Modulating Insulin Receptor Activity With Implications for Diabetes. [PDF]

Arterioscler Thromb Vasc Biol
Rajala R, Griffin CT.
europepmc   +1 more source

Structural basis of Drosophila insulin receptor activation by DILP2 hormone

Shafi T, Moroz OV, Jenkins HT, Chechik M, Iusupov MN, Lubos M, Jiráček J, De Meyts P, Brzozowski AM.   +8 more
europepmc   +1 more source

Editor's Note on 'The human insulin receptor mRNA contains a functional internal ribosome entry segment'. [PDF]

Nucleic Acids Res
europepmc   +1 more source

Insulin receptor and insulin action

, 1995
openaire   +1 more source

[Insulin and insulin receptor disorders].

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1993
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Insulin, insulin receptors, and cancer

Journal of Endocrinological Investigation, 2016
Insulin is a major regulator of cell metabolism but, in addition, is also a growth factor. Insulin effects in target cells are mediated by the insulin receptor (IR), a transmembrane protein with enzymatic (tyrosine kinase) activity. The insulin receptor, however, is represented by a heterogeneous family of proteins, including two different IR isoforms ...
Vigneri R, Goldfine I. D., FRITTITTA, Lucia   +2 more
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Ketoacids and the insulin receptor

Diabetes, 1978
The binding of insulin to a specific receptor on IM-9-cultured human lymphocytes was studied in vitro under conditions simulating diabetic ketoacidosis. Compared with control incubations at pH 7.4, binding was reduced by 19 per cent at pH 7.1 and by 48 per cent at pH 6.8. Addition of β-hydroxybutyrate, at concentrations similar to those seen clinically,
R I, Misbin, A J, Pulkkinen, S A, Lofton, T J, Merimee   +3 more
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Effect of insulin receptor autophosphorylation on insulin receptor binding

Molecular and Cellular Endocrinology, 1986
Insulin receptor beta-subunit autophosphorylation, the first event occurring after insulin binding, plays a crucial role in modulation of receptor-associated kinase activity towards exogenous substrates and possibly in the transmission of biological signals of insulin. Receptor autophosphorylation strongly depends on insulin receptor occupancy.
Gherzi R, ANDRAGHETTI, GABRIELLA, Versari G, CORDERA, RENZO   +3 more
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Insulin Receptor Trafficking: Consequences for Insulin Sensitivity and Diabetes

International Journal of Molecular Sciences, 2019
Insulin receptor (INSR) has been extensively studied in the area of cell proliferation and energy metabolism. Impaired INSR activities lead to insulin resistance, the key factor in the pathology of metabolic disorders including type 2 diabetes mellitus ...
Chen Chen
exaly   +2 more sources

The insulin receptor and the kidney

Current Opinion in Nephrology and Hypertension, 2013
In recent years, it has become clear that the insulin receptor is important in a variety of renal cell types. It is through this transmembrane receptor that insulin, and to a lesser extent insulin-like growth factor, hormones bind and can control important cellular functions.
Hale, Lorna J, Coward, Richard J M
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