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Insulin, insulin receptors, and cancer
Journal of Endocrinological Investigation, 2016Insulin is a major regulator of cell metabolism but, in addition, is also a growth factor. Insulin effects in target cells are mediated by the insulin receptor (IR), a transmembrane protein with enzymatic (tyrosine kinase) activity. The insulin receptor, however, is represented by a heterogeneous family of proteins, including two different IR isoforms ...
Vigneri R +2 more
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Diabetes, 1990
The human insulin-receptor (hINSR) gene spans a region of > 120,000 base pairs (bp) on the short arm of chromosome 19. It is comprised of 22 exons or coding regions that vary in size from 36 to >2500 bp. To a large degree, the introns appear to divide the hINSR gene into segments that encode structural and/or functional elements of the ...
S, Seino, M, Seino, G I, Bell
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The human insulin-receptor (hINSR) gene spans a region of > 120,000 base pairs (bp) on the short arm of chromosome 19. It is comprised of 22 exons or coding regions that vary in size from 36 to >2500 bp. To a large degree, the introns appear to divide the hINSR gene into segments that encode structural and/or functional elements of the ...
S, Seino, M, Seino, G I, Bell
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Insulin downregulates neonatal brain insulin receptors
Biochemical and Biophysical Research Communications, 1984Insulin (2U-regular) was administered intracerebrally or intraperitoneally in newborn rabbit pups, to study the effect of the hormone on brain insulin receptor characteristics. Intraperitoneal insulin treatment produced an increase in plasma insulin concentrations from a control of approximately 24 microU/ml to 132 +/- 36 (p less than 0.02) and a ...
S U, Devaskar, N, Holekamp
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Insulin Receptor Autoimmunity and Insulin Resistance
Journal of Pediatric Endocrinology and Metabolism, 2008The frequency of insulin receptor autoantibodies (IR-ab) was determined among adolescents and young adults with documented insulin resistance syndrome (IRS) with and without concomitant autoimmunity. The study population was comprised of 61 patients with obesity, acanthosis nigricans and insulin resistance (simple IRS); 12 with IRS and other autoimmune
Ping, Zhou +5 more
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Insulin Receptor Antibodies and Insulin Resistance
Southern Medical Journal, 1999The presence of insulin receptor antibodies is a rare cause of insulin resistance. Patients usually have a combination of hyperglycemia, insulin resistance, acanthosis nigricans, and autoimmune features. We report a patient with systemic lupus erythematosus and severe insulin resistance due to insulin receptor antibodies.
C H, Magsino, J, Spencer
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Effect of insulin receptor autophosphorylation on insulin receptor binding
Molecular and Cellular Endocrinology, 1986Insulin receptor beta-subunit autophosphorylation, the first event occurring after insulin binding, plays a crucial role in modulation of receptor-associated kinase activity towards exogenous substrates and possibly in the transmission of biological signals of insulin. Receptor autophosphorylation strongly depends on insulin receptor occupancy.
Gherzi R +3 more
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Insulin Receptors and Insulin Resistance
Annual Review of Medicine, 1983Resistance to the action of insulin plays a central role in many important disease states, including diabetes and obesity. Many insights into the mechanism and significance of insulin resistance in these and other disorders have followed upon our expanding knowledge regarding insulin receptors.
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Diabetes, 1972
Studies with bulky and insoluble insulin derivatives indicate that this hormone can activate various metabolic processes by interaction with cell surface structures. A definition of “receptor” is offered which is operationally useful in studies directed to the identification and purification of receptor structures.
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Studies with bulky and insoluble insulin derivatives indicate that this hormone can activate various metabolic processes by interaction with cell surface structures. A definition of “receptor” is offered which is operationally useful in studies directed to the identification and purification of receptor structures.
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Annales d'endocrinologie, 1996
The cloning of the insulin receptor not only established the primary structure of this membrane-bound glycoprotein but also offered the material necessary for the study of the molecular functions of this tyrosine-kinase receptor using molecular biology tools.
E, Clauser, C, Auzan, I, Leconte
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The cloning of the insulin receptor not only established the primary structure of this membrane-bound glycoprotein but also offered the material necessary for the study of the molecular functions of this tyrosine-kinase receptor using molecular biology tools.
E, Clauser, C, Auzan, I, Leconte
openaire +1 more source