Postnatal β2 adrenergic treatment improves insulin sensitivity in lambs with IUGR but not persistent defects in pancreatic islets or skeletal muscle [PDF]
, 2019 Placental insufficiency causes intrauterine growth restriction (IUGR) and disturbances in glucose homeostasis with associated β adrenergic receptor (ADRβ) desensitization.
Allen, Ronald E. +11 more
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Chromium uptake by Fenugreek [PDF]
, 2012 Fenugreek (Trigonella foenum- graecum) is both herb (leaves) and a spice (seed) belonging to the family Fabaceae. Fenugreek leaves and seeds are used in the cuisine of India. Fenugreek also has medicinal value.
Murthy Ch V R +3 more
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Fibroblasts derived from long-lived insulin receptor substrate 1 null mice are not resistant to multiple forms of stress [PDF]
, 2014 Reduced signalling through the insulin/insulin-like growth factor-1 signalling (IIS) pathway is a highly conserved lifespan determinant in model organisms.
Page, Melissa M. +5 more
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Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. [PDF]
, 2017 Obesity-associated insulin resistance plays a central role in type 2 diabetes. As such, tyrosine phosphatases that dephosphorylate the insulin receptor (IR) are potential therapeutic targets.
Aleshin, Alexander E +22 more
core +2 more sources
The impact of acute rosiglitazone on insulin pharmacokinetics at the blood‐brain barrier
Endocrinology, Diabetes & Metabolism, 2020 Introduction CNS insulin levels are decreased and insulin receptor signalling is dampened in Alzheimer's disease (AD). Increasing CNS insulin levels through a variety of methods has been shown to improve memory.
Demi C. Galindo +2 more
doaj +1 more source
p75 neurotrophin receptor regulates energy balance in obesity [PDF]
, 2016 Obesity and metabolic syndrome reflect the dysregulation of molecular pathways that control energy homeostasis. Here, we show that the p75 neurotrophin receptor (p75NTR) controls energy expenditure in obese mice on a high-fat diet (HFD).
Akassoglou, Katerina +16 more
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ATP sensitizes the insulin receptor to insulin. [PDF]
Proceedings of the National Academy of Sciences, 1988 Insulin receptor with high insulin binding and tyrosine kinase activities has been prepared from human placenta. Based on a molecular mass of 306 kDa for the receptor (the value obtained from the sum of the amino acid residues), this preparation is capable of binding 1.48 mol of insulin per mol of receptor.
Kevin D. Ridge +2 more
openaire +3 more sources
Molecular Genetics and Metabolism Reports, 2023 Severe insulin resistance can be caused by rare genetic defects in the insulin receptor known as insulin receptoropathies. These genetic defects cause a wide spectrum of clinical manifestations ranging from mild syndromes to lethal disorders. Among those
Dalia Cuenca +11 more
doaj
11 beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle [PDF]
, 2009 OBJECTIVE: Glucocorticoid excess is characterized by increased adiposity, skeletal myopathy, and insulin resistance, but the precise molecular mechanisms are unknown.
Morgan, S. A. +14 more
core +4 more sources
The signalling conformation of the insulin receptor ectodomain
Nature Communications, 2018 The insulin receptor plays a key role in many physiological processes, yet how insulin effects receptor signaling at the structural level remains incomplete.
Felix Weis +10 more
doaj +1 more source