Results 131 to 140 of about 271,085 (312)
The stimulus-secretion coupling of glucose-induced insulin release. Metabolic and functional effects of NH4+ in rat islets. [PDF]
Abdullah Sener+7 more
openalex +1 more source
This study integrates dual‐reporter genetics, imaging flow cytometry, and single‐cell sequencing to characterize rare bihormonal cells in mouse and human pancreatic islets. Gcg⁺Ins⁺ cells resemble α‐cells rather than transitional states. Cross‐species gene network analysis refines islet cell taxonomy and reveals human‐specific δ‐cell subtypes ...
Xin‐Xin Yu+10 more
wiley +1 more source
The RhoGAP Stard13 controls insulin secretion through F-actin remodeling
Objective: Actin cytoskeleton remodeling is necessary for glucose-stimulated insulin secretion in pancreatic β-cells. A mechanistic understanding of actin dynamics in the islet is paramount to a better comprehension of β-cell dysfunction in diabetes ...
Heike Naumann+3 more
doaj
The role of sodium and potassium in insulin secretion from rabbit pancreas
C. N. Hales, R. D. G. Milner
openalex +1 more source
Mechanisms of glucose stimulated insulin secretion in health and in diabetes: Some re-evaluations and proposals [PDF]
Erol Cerasi
openalex +1 more source
The effects of intestinal epithelial cells and their exosomes on the hepatic differentiation of HPCs are explored in a gut‐liver‐on‐a‐chip. Exosomes from intestinal epithelial cells improve liver fibrosis. Moreover, the miR‐371‐373 cluster in the exosomes may mediate this effect by regulating the hepatic differentiation of HPCs.
Liang Ye+16 more
wiley +1 more source
THE STIMULUS-SECRETION COUPLING OF GLUCOSE-INDUCED INSULIN RELEASE [PDF]
F Malaisse-Lagae+3 more
openalex +1 more source
Irisin is a crucial plasma biomarker and promising therapeutic target that reflects disease severity, pulmonary vascular remodeling status and clinical outcome in patients with pulmonary arterial hypertension (PAH). As a novel protective factor, irisin is downregulated in PAH. By ubiquitination, irisin promotes Enolase 1 degradation and suppresses cell
Na Sun+15 more
wiley +1 more source
Elevated lactate in diabetes activates the GPR132‐Src pathway in macrophages, inducing macrophage senescence and further enhancing foam cell formation. This mechanism exacerbates atherosclerotic progression. Abstract Diabetes is widely acknowledged as a significant risk factor for atherosclerosis, facilitating plaque formation through various ...
Xiaofeng Ge+10 more
wiley +1 more source