Results 131 to 140 of about 307,626 (315)

Conformable Device for Independent Measurements of Mucosal and Vascular Barriers in a Complex In Vitro Intestinal Model

Advanced Science, EarlyView.
Development of more complex in vitro models necessitates the development of improved monitoring approaches. This work demonstrates a novel conformable device capable of measuring the resistance of two cell barriers within a single model independently, a significant advantage over conventional trans‐epithelial/endothelial electrical resistance (TEER ...
Alexandra Elisabeth Wheeler, Sonja Blasche, Rob Bradley, Rachana Acharya, Sophie Oldroyd, David Bulmer, Kiran R. Patil, Róisín Meabh Owens   +7 more
wiley   +1 more source

Correction for Li et al. , Urocortin 3 regulates glucose-stimulated insulin secretion and energy homeostasis

, 2008

openalex   +1 more source

FSTL1 Orchestrates Metabolic‐Epigenetic Crosstalk: Glycolysis‐Dependent H3K18 Lactylation Drives Cartilage Fibrosis in Osteoarthritis

Advanced Science, EarlyView.
FSTL1 promotes glycolysis during chondrocyte fibrosis by triggering the HIF‐1 signaling pathway, which causes lactate to accumulate. The buildup of lactate leads to changes in histone lysine lactylation, which in turn enhances the expression of genes associated with fibrosis.
Feng Lu, Yunyuan Yu, Guangrong Yin, Huiqun Hu, Shishuo Li, Yuting Tang, Yimin Liu, Maoyuan Li, Liang liang Wang, Chao Xu, Gongyin Zhao, Baojun Zhou, Yuji Wang   +12 more
wiley   +1 more source

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

Acute effects of Amomum villosumLour. fruit extract on postprandial glycemia and insulin secretion: A single-blind, placebo-controlled, crossover study in healthy subjects

, 2020
Ha-Rim Kim, Paulrayer Antonisamy, Yong-Gwan Kwon, Do‐Gon Ryu, Dong-Gi Baek, Ji-Hye Geum, Jung‐Han Lee, Geum-San Lee, Kang‐Beom Kwon   +8 more
openalex   +1 more source

Insulin Secretion after Pancreatoduodenectomy

Annals of Surgery, 1974
M, Miyata, T, Takao, T, Uozumi, E, Okamoto, H, Manabe   +4 more
openaire   +3 more sources

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

Advanced Science, EarlyView.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, Min Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan   +19 more
wiley   +1 more source

Sustained hyperglycemia specifically targets translation of mRNAs for insulin secretion

The Journal of Clinical Investigation
Pancreatic β cells are specialized for coupling glucose metabolism to insulin peptide production and secretion. Acute glucose exposure robustly and coordinately increases translation of proinsulin and proteins required for secretion of mature insulin ...
Abigael Cheruiyot, Jennifer Hollister-Lock, Brooke Sullivan, Hui Pan, Jonathan M. Dreyfuss, Susan Bonner-Weir, Jean E. Schaffer   +6 more
doaj   +1 more source

Metabolic cycling in control of glucose-stimulated insulin secretion

, 2008
Mette V. Jensen, Jamie W. Joseph, Sarah M. Ronnebaum, Shawn C. Burgess, A. Dean Sherry, Christopher B. Newgard   +5 more
openalex   +1 more source

Bidirectional Insulin Granule Turnover in the Submembrane Space During K⁺ Depolarization‐Induced Secretion [PDF]

, 2011
Kathrin Hatlapatka, Magnus Matz, Kirstin Schumacher, Knut Baumann, Ingo Rustenbeck   +4 more
openalex   +1 more source