Results 121 to 130 of about 342,036 (317)
Advanced Science, EarlyView.Electroacupuncture (EA) ameliorates learning and memory function in 5×FAD mice by regulating the brain glucose metabolic network. This neuroprotective effect is closely related to enhancing neuronal energy utilization via the IGF1/IGF1R signaling pathway.
Shengxiang Liang +12 more
wiley +1 more source
, 2004 The cells within the intact islet of Langerhans function as a metabolic syncytium, secreting insulin in a coordinated and oscillatory manner in response to external fuel.
Barry, D.T. +7 more
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, 2015 In this paper, a two-delay model for the ultradian oscillatory behaviour of the glucose-insulin regulation system is studied. Hill functions are introduced to model nonlinear physiological interactions within this system and ranges on parameters ...
Easton, Jonathan +5 more
core +1 more source
The RhoGAP Stard13 controls insulin secretion through F-actin remodeling
Molecular Metabolism, 2018 Objective: Actin cytoskeleton remodeling is necessary for glucose-stimulated insulin secretion in pancreatic β-cells. A mechanistic understanding of actin dynamics in the islet is paramount to a better comprehension of β-cell dysfunction in diabetes ...
Heike Naumann +3 more
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao +11 more
wiley +1 more source
A 3D In Vitro Model of the Human Hepatobiliary Junction
Advanced Science, EarlyView.A 3D human organoid platform reconstructs the hepatobiliary junction between primary adult hepatocytes and intrahepatic cholangiocytes. These adult hepatobiliary organoids (aHBOs) support directional bile transport from canaliculi to ductule‐like structures, enable quantitative imaging of junction dynamics, and reveal cell‐type‐specific vulnerabilities
Ashley D. Westerfield +13 more
wiley +1 more source
Insulin Secretion In Insulin Resistance States
, 2015 Insulin secretion is regulated mainly by glucose stimulus changes and is characterized by first and second phase (biphasic time course). β-cell glucose sensitivity is essential to maintain glucose homeostasis and loss of that capacity has been related to
De Barros-Mazon S. +2 more
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Estudo do efeito e do mecanismo de ação de triterpenos naturais e da 1,25 (OH)2 vitamina D3 na homeostasia da glicose: papel destes compostos como secretagogos de insulina e/ou insulinomiméticos [PDF]
, 2015 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Bioquímica, Florianópolis, 2015.A hiperglicemia crônica proveniente da diminuição da produção insulínica e do aumento da resistência ...
Castro, Allisson Jhonatan Gomes
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Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity
Advanced Science, EarlyView.We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu +17 more
wiley +1 more source
The molecular and cellular biology of pancreatic ß cell differentiation in vitro [PDF]
, 2002 Previous studies have revealed that embryonic stem (ES) cells are capable of differentiating spontaneously towards pancreatic P cells. The use of growth factors and specific agents, such as nicotinamide, can further enhance this effect in a process known
Gammell, Patrick
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