Results 101 to 110 of about 342,036 (317)

Basal hypersecretion of glucagon and insulin from palmitate-exposed human islets depends on FFAR1 but not decreased somatostatin secretion

Scientific Reports, 2017
In obesity fasting levels of both glucagon and insulin are elevated. In these subjects fasting levels of the free fatty acid palmitate are raised. We have demonstrated that palmitate enhances glucose-stimulated insulin secretion from isolated human ...
H. Kristinsson, E. Sargsyan, H. Manell, D. M. Smith, S. O. Göpel, P. Bergsten   +5 more
doaj   +1 more source

Engineered AuNPs/fMWCNT Nanocomposite Electrodes for High‐Sensitivity Methylglyoxal Sensing in Saliva and Sweat for Non‐Invasive Diabetes Monitoring

Advanced Healthcare Materials, EarlyView.
An AuNPs/fMWCNT nanocomposite‐modified screen‐printed carbon electrode was engineered via sequential electrodeposition and integrated into a 3D‐printed microfluidic platform for ultrasensitive methylglyoxal detection. The non‐invasive sensing platform enables rapid analysis in saliva and sweat, highlighting strong potential for wearable point‐of‐care ...
Ahadul Amin Soshi, Md Younus Ali, Dadbeh Pazuki, Matiar M.R. Howlader   +3 more
wiley   +1 more source

Association between glucose peak time in oral glucose tolerance test and insulin secretion during pregnancy

The Journal of Maternal-Fetal & Neonatal Medicine
Objectives This study aimed to develop an efficient method for evaluating islet function in pregnant women by analyzing the peak times of plasma glucose and insulin secretion during an oral glucose tolerance test.Methods This prospective study included ...
Huaying Ye, Yangyang Chang, Huaping Li
doaj   +1 more source

Dynamics of Insulin Secretion from EndoC-βH1 β-Cell Pseudoislets in Response to Glucose and Other Nutrient and Nonnutrient Secretagogues

Journal of Diabetes Research, 2017
The dynamics of insulin secretion were characterized in response to a variety of physiological and pharmacological stimulators and other compounds in perifused pseudoislets generated from cells of the EndoC-βH1 β-cell line.
Hiroki Teraoku, Sigurd Lenzen
doaj   +1 more source

Turning Unpredictable Biomolecule Adsorption to Controlled Corona Formation: Focus on Carbon Nanomaterials

Advanced Materials, EarlyView.
Controlling the protein corona formation onto carbon nanomaterials (CNMs) enhances their functionalities as platforms for cancer theranostics. Here, we reviewed the effects of the intrinsic and acquired properties of CNMs on protein corona formation, the consequent biological and toxicological outcomes, and the strategies to reshape corona formation ...
Yajuan Zou, Yalei Hu, Jie Yu, Naoki Komatsu, Yuta Nishina, Alberto Bianco   +5 more
wiley   +1 more source

Development of Nanoflare Nanosensors for Monitoring Cellular Insulin mRNA in Beta Cells and Islets

Advanced Materials Technologies, EarlyView.
This study presents the design and application of In2‐NF probes for detecting insulin mRNA in beta cells and islets. Using spherical nucleic acid‐coated gold nanoparticles, the probes offer strong fluorescent signals upon hybridization. Their performance is validated across 2D and 3D cultures and rat islets, demonstrating sensitive, real‐time mRNA ...
Yana Hu, Qizheng Zhang, Tianli Hu, Juewen Liu, Hongxing Fu, Xin Zhao, Zijiang Yang, Chenjie Xu   +7 more
wiley   +1 more source

Diabetes Remission and Insulin Secretion after Gastric Bypass in Patients with Body Mass Index < 35 Kg/M2

, 2012
Most morbidly obese patients who undergo gastric bypass experience rapid remission of type 2 diabetes mellitus T2DM but the response in non- morbidly obese patients is not clear .
李威傑;李宜致;徐光漢;莊立民, LEE, WEI-JEI;LEE, YI-CHIH;SER, KONG-HAN;CHUANG, LEE-MING   +1 more
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A central role for GRB10 in regulation of islet function in man

, 2014
Variants in the growth factor receptor-bound protein 10 (GRB10) gene were in a GWAS meta-analysis associated with reduced glucose-stimulated insulin secretion and increased risk of type 2 diabetes (T2D) if inherited from the father, but inexplicably ...
Osmond, C, Kang, HM, Ahlqvist, Emma,, Eriksson, Johan G, Tove Fall, Benjamin F Voight, Paul A. Blomstedt (434502), Lakka, T.A., Salehi, S. Albert, Rainer Rauramaa, Liu, Jie, Mark Walker, McCarthy, Mark I, Blomstedt, P.A., Ann-Christine Syvänen, Liu, J., Tonjes, A., Valeriya Lyssenko (11998), Timo A Lakka, Philippe Froguel (2247), Groop, L, Isomaa, B., Jeffrey R O'Connell, Jackson, Anne U., Fadista, J., Jackson, AU, Cecile Lecoeur, Joao Fadista (2795668), Emma Ahlqvist (135003), Tönjes, A, Kuusisto, J, Hansson, Karin B, Tiinamaija Tuomi, Ola Hansson (88199), Wenny Poon, Karin Hansson, Ola Hansson, Elisabeth Widen (75580), Stančáková, A, Lyssenko, V., Langenberg, C, Yu-Ching Cheng (546877), Johanna Kuusisto (197767), Jalal Taneera, Tove Fall (201258), Groop, L., Shuldiner, Alan R., Wierup, N., Bouatia-Naji, Nabila, Ruth J. F. Loos (110224), Tönjes, Anke, Walker, M, Loos, Ruth J F, Anke Tönjes (103703), Widen, E., Langenberg, Claudia, Vasiliki Lagou (149920), Blomstedt, Paul A, Voight, Benjamin F, Jeffrey R. O'Connell (170220), Eriksson, Johan G., Charlotte Ling, Wierup, Nils,, Frayling, Timothy M., Prasad, RB, Erik Ingelsson, Almgren, P., Nilsson, Peter, Michael N. Weedon (160690), Jie Liu (15128), Palotie, Aarno, Michael Stumvoll, Nabila Bouatia-Naji (149349), Liu, J, Ashish Kumar (152984), Weijia Xie (546876), Vatin, V, Fall, Tove, Hyun Min Kang (145687), Ahlqvist, E., Mark I. McCarthy (145748), Voight, BF, Lagou, Vasiliki, Voight, Benjamin F., Charlotte Ling (253302), Alan R Shuldiner, Jalal Taneera (546879), Ling, Charlotte,, Jari Lahti, Weijia Xie, Isomaa, B, Rauramaa, R, Inga Prokopenko, Kumar, A, Markku Laakso, Salehi, S.A., Stumvoll, M, Maegi, R, Wareham, Nicholas J, Anke Tönjes, Aarno Palotie (41342), Salehi, SA, Eriksson, JG, Palotie, A, Groop, Leif,, Blomstedt, PA, Timothy M Frayling, Bo Isomaa (68893), Poon, Wenny,, Almgren, Peter, Syvänen, Ann-Christine, Cheng, YC, Karin Hansson (546880), Levy-Marchal, C., Ong, KK, Lahti, Jari, Xie, Weijia, Laakso, M, Maegi, Reedik, F Voight, Benjamin,, Dayeh, T, Osmark, P., Alkayyali, S., Ingelsson, Erik, Johan G. Eriksson (150122), Rashmi Prasad B, Vatin, Vincent, Ling, Charlotte, Osmark, Peter,, Magi, R., Salehi, S Albert, Levy-Marchal, Claire, Silver, Kristi D, Ashish Kumar, Ling, C, Widen, Elisabeth, Walker, Mark, McCarthy, MI, Nilsson, P, Shuldiner, A.R., Peter Nilsson (3305), Hansson, Karin, Fall, Tove,, Hansson, O., Andrea Mari (297970), Palotie, A., Blomstedt, Paul A., Prasad B, Rashmi, Wierup, Nils, Lecoeur, C., Kristi D. Silver (546881), Lagou, V., Levy-Marchal, C, Kovacs, P, Isomaa, Bo, Prokopenko, Inga, Fadista, J, Joao Fadista, Wenny Poon (546872), Hansson, Ola,, Stančáková, Alena, Johanna Kuusisto, Alkayyali, Sami,, Lakka, Timo A., McCarthy, Mark I., Silver, Kristi D., Timo A. Lakka (198694), Clive Osmond (286037), Frayling, Timothy M, Lakka, TA, Cecile Lecoeur (4429696), Reedik Mägi (667294), Poon, Wenny, Claire Levy-Marchal, Ong, K.K., Alkayyali, Sami, Taneera, Jalal,, Kang, H.M., Dayeh, Tasnim, Tasnim Dayeh (428020), Wareham, N.J., Weedon, Michael N., F Voight, Benjamin, Vincent Vatin (116624), Sami Alkayyali, Vatin, V., Ong, Ken K, Almgren, Peter,, Lahti, J, Nicholas J Wareham, Tiinamaija Tuomi (12004), Claudia Langenberg, Peter Almgren, Andrea Mari, Prokopenko, I, Dayeh, T., Valeriya Lyssenko, Almgren, P, Tuomi, Tiinamaija,, Lyssenko, Valeriya, Lecoeur, Cecile, Jari Lahti (149903), Timothy M. Frayling (145700), Alkayyali, S, Loos, Ruth J. F., Kovacs, P., Lakka, Timo A, Inga Prokopenko (43252), S Albert Salehi, Langenberg, C., Laakso, M., Lyssenko, V, Prasad, Rashmi B., McCarthy, Mark, Kuusisto, J., Nils Wierup, Cheng, Yu-Ching, Taneera, Jalal, Kovacs, Peter, Loos, RJF, Lahti, J., Jackson, A.U., Reedik Mägi, Prokopenko, I., Lund University., Michael N Weedon, Weedon, Michael N, Ken K. Ong (188600), Mägi, Reedik, Nilsson, Peter,, Hansson, K., Voight, B.F., Mägi, R, Hansson, Ola, Cheng, Y-C, Xie, W, S. Albert Salehi (546874), Syvänen, Ann-Christine,, Johan G Eriksson, Prasad, B.R., Kristi D Silver, Kumar, Ashish, Yu-Ching Cheng, Markku Laakso (197777), Prasad B, R, Aarno Palotie, Vasiliki Lagou, Jie Liu, Ling, C., Xie, W., Ann-Christine Syvänen (57309), Nils Wierup (167236), Hansson, Karin B,, Loos, RJ, Prasad, Rashmi,, Fall, T, Wareham, NJ, Anne U. Jackson (145702), Philippe Froguel, Syvanen, A-C, Frayling, TM, Shuldiner, Alan R, Barker, A, Syvanen, A.C., Kuusisto, Johanna, Emma Ahlqvist, McCarthy, M.I., Hyun Min Kang, Weedon, MN, Ruth J F Loos, Fadista, Joao,, Ong, Ken K., Silver, K.D., Tasnim Dayeh, Taneera, J., Claudia Langenberg (160616), Rainer Rauramaa (211915), Mark Walker (21700), Barker, A., Eriksson, J.G., Vincent Vatin, Adam Barker, Sami Alkayyali (546878), Stumvoll, M., Walker, M., Ken K Ong, Salehi, S Albert,, Lagou, V, Tuomi, T, Alena Stančáková (197764), Osmark, P, Syvänen, AC, Jackson, Anne U, Inglesson, E., Peter Osmark (375761), Mari, Andrea, O'Connell, J.R., Wareham, Nicholas J., Shuldiner, AR, Peter Kovacs (103720), Dayeh, Tasnim,, Stancakova, A., Rashmi Prasad B (546873), Mari, A., Adam Barker (546875), Rauramaa, Rainer, Frayling, T.M., Stumvoll, Michael, Loos, R.J., Bouatia-Naji, N., Osmond, Clive, Mari, A, Froguel, Philippe, Wierup, N, Alena Stančáková, Peter Nilsson, Benjamin F. Voight (145685), Alan R. Shuldiner (110828), Paul A Blomstedt, Fall, T., Silver, KD, Nabila Bouatia-Naji, Mark I McCarthy, Kumar, A., Osmark, Peter, Bouatia-Naji, N, Widen, E, Poon, W, Nilsson, P., Fadista, Joao, Prasad, Rashmi, Palotie, Aarno,, Ingelsson, Erik,, Tuomi, T., Poon, W., Ingelsson, E, Weedon, M.N., Laakso, Markku, O'Connell, JR, Claire Levy-Marchal (76792), O'Connell, Jeffrey R., Lecoeur, C, Leif Groop, Hansson, O, Groop, Leif, Elisabeth Widen, Rauramaa, R., Taneera, J, Hansson, K, Peter Osmark, Peter Almgren (11999), O'Connell, Jeffrey R, Kang, Hyun Min, Ahlqvist, E, Froguel, P., Erik Ingelsson (232651), Peter Kovacs, Michael Stumvoll (103716), Bo Isomaa, Clive Osmond, Cheng, Y.C., Anne U Jackson, Nicholas J. Wareham (110277), Leif Groop (12005), Froguel, P, Ahlqvist, Emma, Barker, Adam, Tuomi, Tiinamaija, Lyssenko, Valeriya,   +368 more
core   +1 more source

Topography‐Regulated Screening Platform for Myoblast Contact Guidance

Advanced Materials Technologies, EarlyView.
This study develops a topography‐regulated screening platform (12 gradients in 96‐topography‐well plate) enabling analysis of skeletal muscle morphogenesis. The topography‐induced cell morphology changed, cell polarization, and myotube differentiation, establishing an evaluative framework for generating pathologically relevant myotube phenotypes to ...
Tianqi Feng, Torben A.B. van der Boon, Savannah Amy Haupt, Adam Jones, Yanjing Ji, Theo G. Van Kooten, Patrick van Rijn   +6 more
wiley   +1 more source

The effects of the adipocyte-secreted proteins resistin and visfatin on the pancreatic beta-cell [PDF]

, 2009
A thesis submitted in partial fulfilment of the requirements of the University of Wolverhampton for degree of Doctor of PhilosophyAdipose tissue secreted proteins (adipokines) have been proposed to form a link between obesity and type 2 diabetes (T2D ...
Onyango, David J.
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