Results 101 to 110 of about 543,808 (360)
Advanced Healthcare Materials, EarlyView.A paracrine factor local gradient (PFLG)‐generating system enables microvessel penetration across 3D hepatocyte tissues. The resulting vascularized constructs recapitulate hepatic sinusoidal hepatocyte—endothelial contact architecture and enhance hepatic functions in vitro.
Yen‐Hsiang Huang +2 more
wiley +1 more source
Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells.
PLoS ONE, 2015 Statins are widely used in the treatment of hypercholesterolemia and are efficient in the prevention of cardiovascular disease. Molecular mechanisms explaining statin-induced impairment in insulin secretion remain largely unknown.
Nagendra Yaluri +6 more
doaj +1 more source
Pancreatic Thyrotropin Releasing Hormone and Mechanism of Insulin Secretion
Cellular Physiology and Biochemistry, 2018 Thyrotropin releasing hormone (TRH; pGlu-His-ProNH2) is expressed also in pancreatic β cells where it is colocalized in secretory granules with insulin.
Vladimír Štrbák
doaj +1 more source
Oestrogens and insulin secretion [PDF]
Diabetologia, 2005 There is a persistent perception that oestrogens have an adverse effect on carbohydrate metabolism. It might therefore be expected that their use would result in a corresponding increase in the incidence of diabetes. Recent evidence from clinical trials suggesting that women on postmenopausal oestrogen hormone replacement therapy (HRT) have a reduced ...
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim +4 more
wiley +1 more source
Journal of Diabetes Research, 2017 The dynamics of insulin secretion were characterized in response to a variety of physiological and pharmacological stimulators and other compounds in perifused pseudoislets generated from cells of the EndoC-βH1 β-cell line.
Hiroki Teraoku, Sigurd Lenzen
doaj +1 more source
Three‐Dimensional Ovary Model to Improve and Study Murine Follicle Growth
Advanced Healthcare Materials, EarlyView.To develop new methods for fertility preservation in women, novel culture systems for small follicles need to be established. In this work, a poly(ethylene glycol) based scaffold, with appropriate mechanical and bioactive features to support mouse follicle and ovary cell growth is developed, and the formed cell‐follicle interactions are visualized ...
Mira Jacobs +6 more
wiley +1 more source
PLoS ONE, 2016 Type 2 diabetes (T2D) is the result of metabolic defects in insulin secretion and insulin sensitivity, yet most T2D loci identified to date influence insulin secretion.
Jacob M Keaton +15 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Engineered microparticle topographies direct human mesenchymal stem cell osteogenesis without biochemical additives. This osteogenic commitment is driven by canonical Hedgehog signaling and followed by temporal IGF‐II engagement. Two‐photon polymerization demonstrates spatial control, enabling the engineering of topographical gradients that pattern ...
Fatmah I. Ghuloum +5 more
wiley +1 more source
The Journal of Maternal-Fetal & Neonatal MedicineObjectives This study aimed to develop an efficient method for evaluating islet function in pregnant women by analyzing the peak times of plasma glucose and insulin secretion during an oral glucose tolerance test.Methods This prospective study included ...
Huaying Ye, Yangyang Chang, Huaping Li
doaj +1 more source