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Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT
Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...Osman Corbali, Priyanka Menon, Halil I. Corbali, Ram Jagannathan, Allan I. Levey +4 morewiley +1 more sourceA central role for GRB10 in regulation of islet function in man [PDF]
, 2014 Variants in the growth factor receptor-bound protein 10 (GRB10) gene were in a GWAS meta-analysis associated with reduced glucose-stimulated insulin secretion and increased risk of type 2 diabetes (T2D) if inherited from the father, but inexplicably ...Osmond, C, Kang, HM, Ahlqvist, Emma,, Eriksson, Johan G, Tove Fall, Benjamin F Voight, Paul A. Blomstedt (434502), Lakka, T.A., Salehi, S. Albert, Rainer Rauramaa, Liu, Jie, Mark Walker, McCarthy, Mark I, Blomstedt, P.A., Ann-Christine Syvänen, Liu, J., Tonjes, A., Valeriya Lyssenko (11998), Timo A Lakka, Philippe Froguel (2247), Groop, L, Isomaa, B., Jeffrey R O'Connell, Jackson, Anne U., Fadista, J., Jackson, AU, Cecile Lecoeur, Joao Fadista (2795668), Emma Ahlqvist (135003), Tönjes, A, Kuusisto, J, Hansson, Karin B, Tiinamaija Tuomi, Ola Hansson (88199), Wenny Poon, Karin Hansson, Ola Hansson, Elisabeth Widen (75580), Stančáková, A, Lyssenko, V., Langenberg, C, Yu-Ching Cheng (546877), Johanna Kuusisto (197767), Jalal Taneera, Tove Fall (201258), Groop, L., Shuldiner, Alan R., Wierup, N., Bouatia-Naji, Nabila, Ruth J. F. Loos (110224), Tönjes, Anke, Walker, M, Loos, Ruth J F, Anke Tönjes (103703), Widen, E., Langenberg, Claudia, Vasiliki Lagou (149920), Blomstedt, Paul A, Voight, Benjamin F, Jeffrey R. O'Connell (170220), Eriksson, Johan G., Charlotte Ling, Wierup, Nils,, Frayling, Timothy M., Prasad, RB, Erik Ingelsson, Almgren, P., Nilsson, Peter, Michael N. Weedon (160690), Jie Liu (15128), Palotie, Aarno, Michael Stumvoll, Nabila Bouatia-Naji (149349), Liu, J, Ashish Kumar (152984), Weijia Xie (546876), Vatin, V, Fall, Tove, Hyun Min Kang (145687), Ahlqvist, E., Mark I. McCarthy (145748), Voight, BF, Lagou, Vasiliki, Voight, Benjamin F., Charlotte Ling (253302), Alan R Shuldiner, Jalal Taneera (546879), Ling, Charlotte,, Jari Lahti, Weijia Xie, Isomaa, B, Rauramaa, R, Inga Prokopenko, Kumar, A, Markku Laakso, Salehi, S.A., Stumvoll, M, Maegi, R, Wareham, Nicholas J, Anke Tönjes, Aarno Palotie (41342), Salehi, SA, Eriksson, JG, Palotie, A, Groop, Leif,, Blomstedt, PA, Timothy M Frayling, Bo Isomaa (68893), Poon, Wenny,, Almgren, Peter, Syvänen, Ann-Christine, Cheng, YC, Karin Hansson (546880), Levy-Marchal, C., Ong, KK, Lahti, Jari, Xie, Weijia, Laakso, M, Maegi, Reedik, F Voight, Benjamin,, Dayeh, T, Osmark, P., Alkayyali, S., Ingelsson, Erik, Johan G. Eriksson (150122), Rashmi Prasad B, Vatin, Vincent, Ling, Charlotte, Osmark, Peter,, Magi, R., Salehi, S Albert, Levy-Marchal, Claire, Silver, Kristi D, Ashish Kumar, Ling, C, Widen, Elisabeth, Walker, Mark, McCarthy, MI, Nilsson, P, Shuldiner, A.R., Peter Nilsson (3305), Hansson, Karin, Fall, Tove,, Hansson, O., Andrea Mari (297970), Palotie, A., Blomstedt, Paul A., Prasad B, Rashmi, Wierup, Nils, Lecoeur, C., Kristi D. Silver (546881), Lagou, V., Levy-Marchal, C, Kovacs, P, Isomaa, Bo, Prokopenko, Inga, Fadista, J, Joao Fadista, Wenny Poon (546872), Hansson, Ola,, Stančáková, Alena, Johanna Kuusisto, Alkayyali, Sami,, Lakka, Timo A., McCarthy, Mark I., Silver, Kristi D., Timo A. Lakka (198694), Clive Osmond (286037), Frayling, Timothy M, Lakka, TA, Cecile Lecoeur (4429696), Reedik Mägi (667294), Poon, Wenny, Claire Levy-Marchal, Ong, K.K., Alkayyali, Sami, Taneera, Jalal,, Kang, H.M., Dayeh, Tasnim, Tasnim Dayeh (428020), Wareham, N.J., Weedon, Michael N., F Voight, Benjamin, Vincent Vatin (116624), Sami Alkayyali, Vatin, V., Ong, Ken K, Almgren, Peter,, Lahti, J, Nicholas J Wareham, Tiinamaija Tuomi (12004), Claudia Langenberg, Peter Almgren, Andrea Mari, Prokopenko, I, Dayeh, T., Valeriya Lyssenko, Almgren, P, Tuomi, Tiinamaija,, Lyssenko, Valeriya, Lecoeur, Cecile, Jari Lahti (149903), Timothy M. Frayling (145700), Alkayyali, S, Loos, Ruth J. F., Kovacs, P., Lakka, Timo A, Inga Prokopenko (43252), S Albert Salehi, Langenberg, C., Laakso, M., Lyssenko, V, Prasad, Rashmi B., McCarthy, Mark, Kuusisto, J., Nils Wierup, Cheng, Yu-Ching, Taneera, Jalal, Kovacs, Peter, Loos, RJF, Lahti, J., Jackson, A.U., Reedik Mägi, Prokopenko, I., Lund University., Michael N Weedon, Weedon, Michael N, Ken K. Ong (188600), Mägi, Reedik, Nilsson, Peter,, Hansson, K., Voight, B.F., Mägi, R, Hansson, Ola, Cheng, Y-C, Xie, W, S. Albert Salehi (546874), Syvänen, Ann-Christine,, Johan G Eriksson, Prasad, B.R., Kristi D Silver, Kumar, Ashish, Yu-Ching Cheng, Markku Laakso (197777), Prasad B, R, Aarno Palotie, Vasiliki Lagou, Jie Liu, Ling, C., Xie, W., Ann-Christine Syvänen (57309), Nils Wierup (167236), Hansson, Karin B,, Loos, RJ, Prasad, Rashmi,, Fall, T, Wareham, NJ, Anne U. Jackson (145702), Philippe Froguel, Syvanen, A-C, Frayling, TM, Shuldiner, Alan R, Barker, A, Syvanen, A.C., Kuusisto, Johanna, Emma Ahlqvist, McCarthy, M.I., Hyun Min Kang, Weedon, MN, Ruth J F Loos, Fadista, Joao,, Ong, Ken K., Silver, K.D., Tasnim Dayeh, Taneera, J., Claudia Langenberg (160616), Rainer Rauramaa (211915), Mark Walker (21700), Barker, A., Eriksson, J.G., Vincent Vatin, Adam Barker, Sami Alkayyali (546878), Stumvoll, M., Walker, M., Ken K Ong, Salehi, S Albert,, Lagou, V, Tuomi, T, Alena Stančáková (197764), Osmark, P, Syvänen, AC, Jackson, Anne U, Inglesson, E., Peter Osmark (375761), Mari, Andrea, O'Connell, J.R., Wareham, Nicholas J., Shuldiner, AR, Peter Kovacs (103720), Dayeh, Tasnim,, Stancakova, A., Rashmi Prasad B (546873), Mari, A., Adam Barker (546875), Rauramaa, Rainer, Frayling, T.M., Stumvoll, Michael, Loos, R.J., Bouatia-Naji, N., Osmond, Clive, Mari, A, Froguel, Philippe, Wierup, N, Alena Stančáková, Peter Nilsson, Benjamin F. Voight (145685), Alan R. Shuldiner (110828), Paul A Blomstedt, Fall, T., Silver, KD, Nabila Bouatia-Naji, Mark I McCarthy, Kumar, A., Osmark, Peter, Bouatia-Naji, N, Widen, E, Poon, W, Nilsson, P., Fadista, Joao, Prasad, Rashmi, Palotie, Aarno,, Ingelsson, Erik,, Tuomi, T., Poon, W., Ingelsson, E, Weedon, M.N., Laakso, Markku, O'Connell, JR, Claire Levy-Marchal (76792), O'Connell, Jeffrey R., Lecoeur, C, Leif Groop, Hansson, O, Groop, Leif, Elisabeth Widen, Rauramaa, R., Taneera, J, Hansson, K, Peter Osmark, Peter Almgren (11999), O'Connell, Jeffrey R, Kang, Hyun Min, Ahlqvist, E, Froguel, P., Erik Ingelsson (232651), Peter Kovacs, Michael Stumvoll (103716), Bo Isomaa, Clive Osmond, Cheng, Y.C., Anne U Jackson, Nicholas J. Wareham (110277), Leif Groop (12005), Froguel, P, Ahlqvist, Emma, Barker, Adam, Tuomi, Tiinamaija, Lyssenko, Valeriya, +368 morecore +1 more sourceAn Integrated Oxygen‐Supplying Device and Predictive Multiphysics Model for Extended Ambient Transport of Insulin‐Producing Cells
Advanced Functional Materials, EarlyView.Cell therapies typically rely on cold‐chain logistics and cryopreservation, limiting access and compromising cell quality. Here, a dual‐chamber device separates an oxygen‐supplying chamber from a hyaluronic acid cargo chamber, sustaining oxygen delivery for over 70 h and enabling ambient‐temperature shipment.Daniel A. Domingo‐Lopez, Ruth Tarpey, Benjamin Brennan, Bryan D. Boyle, Amir M. Alsharabasy, Abhik Mallick, Gabriella Bellavia, Abhay Pandit, Garry P. Duffy, Ruth E. Levey +9 morewiley +1 more sourceSpatially Controlled Embedded Bioprinting of Prevascularized Spheroids‐Containing Biopatch Enables Functional Skin Regeneration
Advanced Healthcare Materials, EarlyView.A spatially controlled embedded bioprinting strategy enables precise engineering of prevascularized multicellular spheroids within skin‐derived dECM bioinks. Optimized spheroid size, composition, and spacing promote vascular maturation, paracrine signaling, and tissue integration, resulting in enhanced angiogenesis, blood perfusion, and functional skin Minjun Ahn, Gyu Tae Park, Dongjun Lee, Sik Yoon, Sae‐Ock Oh, Jae Ho Kim, Byoung Soo Kim +6 morewiley +1 more sourceInvolvement of the Adhesion GPCRs Latrophilins in the Regulation of Insulin Release
Cell Reports, 2019 Summary: Insulin secretion from pancreatic β cells is a highly complex and tightly regulated process. Its dysregulation is one characteristic of type 2 diabetes, and thus, an in-depth understanding of the mechanisms controlling insulin secretion is ...Juliane Röthe, Doreen Thor, Jana Winkler, Alexander B. Knierim, Claudia Binder, Sandra Huth, Robert Kraft, Sven Rothemund, Torsten Schöneberg, Simone Prömel +9 moredoaj +1 more sourceTargeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing
Advanced Healthcare Materials, EarlyView.Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong +10 morewiley +1 more source
