Results 71 to 80 of about 989,753 (307)

ARHGAP21 Acts as an Inhibitor of the Glucose-Stimulated Insulin Secretion Process

Frontiers in Endocrinology, 2020
ARHGAP21 is a RhoGAP protein implicated in the modulation of insulin secretion and energy metabolism. ARHGAP21 transient-inhibition increase glucose-stimulated insulin secretion (GSIS) in neonatal islets; however, ARHGAP21 heterozygote mice have a ...
Sandra M. Ferreira, José M. Costa-Júnior, Mirian A. Kurauti, Nayara C. Leite, Fernanda Ortis, Luiz F. Rezende, Helena C. Barbosa, Antonio C. Boschero, Gustavo J. Santos   +8 more
doaj   +1 more source

Modulation of large dense core vesicle insulin content mediates rhythmic hormone release from pancreatic beta cells over the 24h cycle. [PDF]

PLoS ONE, 2018
The rhythmic nature of insulin secretion over the 24h cycle in pancreatic islets has been mostly investigated using transcriptomics studies showing that modulation of insulin secretion over this cycle is achieved via distal stages of insulin secretion ...
Aurore Quinault, Corinne Leloup, Geoffrey Denwood, Coralie Spiegelhalter, Marianne Rodriguez, Philippe Lefebvre, Nadia Messaddeq, Quan Zhang, Catherine Dacquet, Luc Pénicaud, Stephan C Collins   +10 more
doaj   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion. [PDF]

PLoS ONE, 2010
BACKGROUND:Single nucleotide polymorphisms (SNPs) from GCK, GCKR, G6PC2 and MTNR1B were found to modulate the fasting glucose levels. The current study aimed to replicate this association in the Chinese population and further analyze their effects on ...
Cheng Hu, Rong Zhang, Congrong Wang, Weihui Yu, Jingyi Lu, Xiaojing Ma, Jie Wang, Feng Jiang, Shanshan Tang, Yuqian Bao, Kunsan Xiang, Weiping Jia   +11 more
doaj   +1 more source

Oestrogens and insulin secretion [PDF]

Diabetologia, 2005
There is a persistent perception that oestrogens have an adverse effect on carbohydrate metabolism. It might therefore be expected that their use would result in a corresponding increase in the incidence of diabetes. Recent evidence from clinical trials suggesting that women on postmenopausal oestrogen hormone replacement therapy (HRT) have a reduced ...
openaire   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Evaluation of glucose tolerance test and surrogate indexes of insulin sensitivity to detect insulin resistance syndrome in transition dairy cows [PDF]

, 2013
Healthy multiparous Holstein-Fresian cows (n=101, parity ≥ 2) from 3 large-scale dairy herds in Italy were subjected to an intravenous glucose tolerance test (GTT) 14-1 d before (Week -1) and 3-9 d after calving (Week +1).
Riuzzi, Sara
core  

Myricetin Amplifies Glucose–Stimulated Insulin Secretion via the cAMP-PKA-Epac-2 Signaling Cascade

Biomedicines
Aim: Myricetin, a natural bioflavonoid, is reported as an anti-diabetic agent since it possesses the ability to inhibit α-glucosidase activity, stimulate insulin action and secretion, manage ROS, and prevent diabetes complications.
Akhtar Ali, Zahida Memon, Abdul Hameed, Zaheer Ul-Haq, Muneeb Ali, Rahman M. Hafizur   +5 more
doaj   +1 more source

Acute Kidney Injury After Mechanical Thrombectomy for Stroke in Patients With Pre‐Existing Renal Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk, Marcel Pilarek, Emilia Jaworska, Natalia Kardas, Oliwia Barnaś, Julia Woźniak, Iga Machała, Julia Węgrzynek‐Gallina, Joanna Siuda, Anna Hawrot‐Kawecka, Anetta Lasek‐Bal   +10 more
wiley   +1 more source

Aldosterone status associates with insulin resistance in patients with heart failure-data from the ALOFT study [PDF]

, 2009
<b>Background</b>: Aldosterone plays a key role in the pathophysiology of heart failure. In around 50% of such patients, aldosterone 'escapes' from inhibition by drugs that interrupt the renin-angiotensin axis; such patients have a worse ...
Freel, E.M., Latini, R., Connell, J.M.C., Tsorlalis, I.K., Lewsey, J.D., McMurray, J.J.V., Pitt, B., Maggioni, A.P., Solomon, S.   +8 more
core   +1 more source