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Alzheimer's disease-related cortical proteins modify the association of brain insulin signaling with cognitive decline. [PDF]
J Alzheimers DisTong H +6 more
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LIN-39 is a neuron-specific developmental determinant of longevity in Caenorhabditis elegans with reduced insulin signaling. [PDF]
Nat CommunKavšek A +5 more
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Insulin signaling in development
Development, 2023ABSTRACT Nutrient intake is obligatory for animal growth and development, but nutrients alone are not sufficient. Indeed, insulin and homologous hormones are required for normal growth even in the presence of nutrients. These hormones communicate nutrient status between organs, allowing animals to coordinate growth and metabolism with ...
Miyuki Suzawa, Michelle L. Bland
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Insulin signaling in the adipocyte
International Journal of Obesity, 2000Mammalian adipose tissue serves a number of functions, including storage of nutrients for periods of fasting and control of organismal metabolism. Critical to these functions is the capacity of the fat cell to respond to insulin with a significant increase in glucose uptake.
S A, Summers +2 more
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Insulin signaling in the heart
American Journal of Physiology-Endocrinology and Metabolism, 2021Insulin receptors are highly expressed in the heart and vasculature. Insulin signaling regulates cardiac growth, survival, substrate uptake, utilization, and mitochondrial metabolism. Insulin signaling modulates the cardiac responses to physiological and pathological stressors.
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Biochemical Society Transactions, 2008
Studies in transgenic animals, rodent insulin-secreting cell lines and rodent islets suggest that insulin acts in an autocrine manner to regulate β-cell mass and gene expression. Very little is known about the in vitro roles played by insulin in human islets, and the regulatory role of insulin in protecting against β-cell apoptosis.
Persaud, S J, Muller, D, Jones, P M
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Studies in transgenic animals, rodent insulin-secreting cell lines and rodent islets suggest that insulin acts in an autocrine manner to regulate β-cell mass and gene expression. Very little is known about the in vitro roles played by insulin in human islets, and the regulatory role of insulin in protecting against β-cell apoptosis.
Persaud, S J, Muller, D, Jones, P M
openaire +3 more sources
Journal of Cell Science, 2001
ABSTRACT Insulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (IRS-1, IRS-2 and IRS-3) by the insulin receptor tyrosine kinase. This allows association of IRSs with the regulatory subunit of phosphoinositide 3-kinase (PI3K) through its
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ABSTRACT Insulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (IRS-1, IRS-2 and IRS-3) by the insulin receptor tyrosine kinase. This allows association of IRSs with the regulatory subunit of phosphoinositide 3-kinase (PI3K) through its
openaire +2 more sources