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Modulation of insulin signalling by insulin sensitizers
Biochemical Society Transactions, 2005Insulin resistance is a hallmark of Type II diabetes. It is well documented that insulin sensitizers such as peroxisome-proliferator-activated receptor γ agonists and aspirin improve insulin action in vivo. The detailed mechanisms by which the insulin sensitizers promote insulin signalling, however, are not completely understood and remain somewhat ...
G, Jiang, B B, Zhang
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Insulin Action and the Insulin Signaling Network*
Endocrine Reviews, 1995I. Introduction IN THE fasted state, glucose homeostasis depends upon the balance between hepatic glucose production and glucose utilization by the major insulin-dependent tissues, such as liver, adipose, and muscle, and by insulin-independent tissues, such as brain and kidney. This balance is tightly regulated by pancreatic hormones.
B, Cheatham, C R, Kahn
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Insulin signaling in the vasculature
Frontiers in Bioscience, 2003An abnormal vasodilation is a major defect observed in the arteries of diabetic and hypertensive individuals. Myosin bound phosphatase (MBP) dephosphorylates myosin light chains which play a dominant role in vascular smooth muscle (VSM) contraction.
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The insulin signalling network
Nature MetabolismInsulin signalling is a central regulator of metabolism, orchestrating nutrient homeostasis and coordinating carbohydrate, protein and lipid metabolism. This network operates through dynamic, tightly regulated protein phosphorylation events involving key kinases such as AKT, shaping cellular responses with remarkable precision.
James G. Burchfield +2 more
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Insulin Resistant States and Insulin Signaling
Clinical Chemistry and Laboratory Medicine, 2003The incidence of type 2 diabetes mellitus (T2D) and obesity is increasing rapidly worldwide, reaching epidemic proportions. Insulin resistance is a key feature in both conditions and plays an important pathophysiological role. Over the last two decades a central role in the origin of insulin resistance has emerged for defects in the intracellular ...
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[Insulin signaling and insulin resistance].
Therapie, 2008Insulin controls carbohydrate and lipid metabolism. Among other things, it stimulates glucose storage as glycogen and lipid storage as triglycerides. Insulin acts through a membrane receptor which is a tyrosine kinase. When activated by insulin binding, the tyrosine kinase will recruit and phosphorylate intracellular substrates called IRS (insulin ...
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Insulin signalling in hypothalamic neurones
Journal of Neuroendocrinology, 2020AbstractSubsequent to the discovery of insulin by Banting and Best in the Department of Physiology at the University of Toronto 100 years ago, the field of insulin signalling and action has grown at a remarkable pace. Yet, the recognition that insulin action in the brain is critical for whole body homeostasis has only recently been appreciated.
Denise D. Belsham, Prasad S. Dalvi
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Insulin receptors and insulin signalling
1995International ...
Taouis, Mohammed, Simon, J.
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Insulin signaling in insulin-dysregulated Icelandic horses
Domestic Animal EndocrinologyThe underlying molecular mechanisms leading to insulin dysregulation are poorly understood in horses. Therefore, this study aimed to determine if insulin dysregulation is associated with an altered basal expression and extent of phosphorylation of key proteins of the insulin signaling cascade in liver (LT), muscle (MT), and subcutaneous adipose tissue (
F. Frers +4 more
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Putting the Brakes on Insulin Signaling
New England Journal of Medicine, 2003The discovery of a molecule that interferes with a component of the insulin-signaling pathway provides a target for drug development.
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