Results 71 to 80 of about 3,155,278 (304)
The role of psychological insulin resistance in diabetes self‐care management
Nursing Open, 2020 Aims The purpose of this study was to identify the role of psychological insulin resistance in the relationship between diabetes self‐efficacy and diabetes self‐care management in people with diabetes over 65 years of age.
Ancho Lim, Youngshin Song
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Novel Therapy in the Management of Insulin Resistance
, 2021 Insulin resistance is a growing phenomenon currently due to the increasing risk factors in modern society. Therefore, treatment of insulin resistance should be of great importance to decrease morbidity and mortality.
Wu, Pei-Ju
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Insulin Therapy in Type 2 Diabetes Mellitus: the Need for Early Initiation and Opportunity to Choose
Mìžnarodnij Endokrinologìčnij Žurnal, 2015 Achieving target values of glycemic profile — the main objective of therapy for type 2 diabetes mellitus (DM2). Early administration of insulin enables not only to lower glycemic parameters quickly and effectively and to compensate carbohydrate ...
I.Yu. Golovach, O.V. Diachоk
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Mìžnarodnij Endokrinologìčnij Žurnal, 2013 The article deals with insulin therapy in patients with diabetes mellitus. Detailed characteristic of some insulin preparations is provided.
O.V. Korpacheva-Zinych +2 more
doaj +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Incidence of insulin-treated diabetes in Australia 2000-2011 [PDF]
, 2014 Australia\u27s rate of incidence of insulin-treated diabetes has remained stable over the last decade, with between 10 and 12 new cases per 100,000 population per year.
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