Results 61 to 70 of about 3,155,278 (304)
Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling [PDF]
, 2001 The "metabolic cocktail" comprising glucose-insulin-potassium administrated at reperfusion reduces infarct size in the in vivo rat heart. We propose that insulin is the major component mediating this protection and acts via Akt prosurvival signaling ...
Sack, M.N. +3 more
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Combination therapy in type 2 diabetes mellitus: adding empagliflozin to basal insulin
, 2015 Type 2 diabetes mellitus (T2DM) management is complex, with few patients successfully achieving recommended glycemic targets with monotherapy, most progressing to combination therapy, and many eventually requiring insulin. Sodium glucose cotransporter 2 (
Andrew Ahmann
core +1 more source
Influence of Insulin Pen Needle Geometry on Pain Perception and Patient’s Acceptability: A Review
TechnologiesDiabetes is one of the most common diseases worldwide, with an increasing number of people affected. Insulin therapy is still the major treatment for both Type 1 and Type 2 diabetes and has evolved from bulky syringes to modern insulin pens introduced in
Francesca De Tommasi, Sergio Silvestri
doaj +1 more source
The Psychiatric Bulletin, 2014 Anyone working in an insulin unit in the 1950s would not recognise Dr Pimm’s account of the results of their treatment,1 or details of what it involved. The patients received daily and increasing doses of insulin, rising to many hundreds of units, for a 6-week period.
openaire +2 more sources
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
, 2023 ‘Is Insulin Right for Me?’: Web-based intervention to reduce psychological barriers to insulin therapy among adults with non-insulin-treated type 2 diabetes—A randomised controlled ...
S Baptista (14470488) +7 more
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Diabetes, Metabolic Syndrome and Obesity, 2022 Kai-Fang Hua,1,2 Ming-You Zhang,2 Yao Zhang,2 Bing-Jie Ren,2 Yan-Hui Wu1 1Department of Endocrinology, Xiang’ an Hospital of Xiamen University, Xiamen, Fujian, People’ s Republic of China; 2School of Medicine, Xiamen University, Xiamen, Fujian, People’ s
Hua KF, Zhang MY, Zhang Y, Ren BJ, Wu YH
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
The failing diabetic patient in primary care [PDF]
, 2006 Diabetes is a progressive disorder. The majority of people with Type 2 diabetes are likely to require more intensive treatment regimes over time and a substantial proportion have sub-optimal glycaemic control as measured by glycated haemoglobin (HbA1c ...
Jeavons, David Anthony
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