Results 61 to 70 of about 445,193 (314)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
The failing diabetic patient in primary care [PDF]
, 2006 Diabetes is a progressive disorder. The majority of people with Type 2 diabetes are likely to require more intensive treatment regimes over time and a substantial proportion have sub-optimal glycaemic control as measured by glycated haemoglobin (HbA1c ...
Jeavons, David Anthony
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Diabetes, Metabolic Syndrome and Obesity, 2022 Kai-Fang Hua,1,2 Ming-You Zhang,2 Yao Zhang,2 Bing-Jie Ren,2 Yan-Hui Wu1 1Department of Endocrinology, Xiang’ an Hospital of Xiamen University, Xiamen, Fujian, People’ s Republic of China; 2School of Medicine, Xiamen University, Xiamen, Fujian, People’ s
Hua KF, Zhang MY, Zhang Y, Ren BJ, Wu YH
doaj
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
The role of psychological insulin resistance in diabetes self‐care management
Nursing Open, 2020 Aims The purpose of this study was to identify the role of psychological insulin resistance in the relationship between diabetes self‐efficacy and diabetes self‐care management in people with diabetes over 65 years of age.
Ancho Lim, Youngshin Song
doaj +1 more source
Novel Therapy in the Management of Insulin Resistance
, 2021 Insulin resistance is a growing phenomenon currently due to the increasing risk factors in modern society. Therefore, treatment of insulin resistance should be of great importance to decrease morbidity and mortality.
Wu, Pei-Ju
core
Association of high-sensitive C-reactive protein with advanced stage beta-cell dysfunction and insulin resistance in patients with type 2 diabetes mellitus [PDF]
, 2006 Background: Type 2 diabetes mellitus is associated with increased cardiovascular risk. One laboratory marker for cardiovascular risk assessment is high-sensitivity C-reactive protein (hsCRP).
Standl, Eberhard +8 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Insulin Therapy in Type 2 Diabetes Mellitus: the Need for Early Initiation and Opportunity to Choose
Mìžnarodnij Endokrinologìčnij Žurnal, 2015 Achieving target values of glycemic profile — the main objective of therapy for type 2 diabetes mellitus (DM2). Early administration of insulin enables not only to lower glycemic parameters quickly and effectively and to compensate carbohydrate ...
I.Yu. Golovach, O.V. Diachоk
doaj +1 more source