Results 41 to 50 of about 414,852 (267)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Difficulties of stable metabolic compensation of type 1 diabetes mellitus in adolescents
Лечащий Врач, 2021 The purpose of this report is to discuss the main factors that prevent the stable metabolic compensation of type 1 diabetes mellitus in adolescents, which must be taken into account in the management of the patient, the selection and control of therapy ...
E. B. Bashnina, I. M. Cargasova
doaj
Minimizing Hypoglycemia with Insulin Therapy: The “THINK” Strategy
Chronicle of Diabetes Research and Practice, 2022 Iatrogenic hypoglycemia is the most feared and common complication of insulin therapy. Hypoglycemia can have serious consequences and can be potentially life-threatening. In addition to the neurological manifestations of severe hypoglycemia, hypoglycemia
Gagan Priya, Emmy Grewal
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Psychological insulin resistance among patients with diabetes mellitus in Botswana
African Journal of Primary Health Care & Family MedicineBackground: Timely initiation of insulin therapy is vital in patients with type 2 diabetes mellitus. However, insulin initiation may be delayed because of psychological insulin resistance (PIR).
Engemadzo Bitsang +2 more
doaj +1 more source
The Psychiatric Bulletin, 2014 Anyone working in an insulin unit in the 1950s would not recognise Dr Pimm’s account of the results of their treatment,1 or details of what it involved. The patients received daily and increasing doses of insulin, rising to many hundreds of units, for a 6-week period.
openaire +2 more sources
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Influence of Insulin Pen Needle Geometry on Pain Perception and Patient’s Acceptability: A Review
TechnologiesDiabetes is one of the most common diseases worldwide, with an increasing number of people affected. Insulin therapy is still the major treatment for both Type 1 and Type 2 diabetes and has evolved from bulky syringes to modern insulin pens introduced in
Francesca De Tommasi, Sergio Silvestri
doaj +1 more source