Results 51 to 60 of about 445,193 (314)

Insulin coma therapy [PDF]

The Psychiatric Bulletin, 2014
Anyone working in an insulin unit in the 1950s would not recognise Dr Pimm’s account of the results of their treatment,1 or details of what it involved. The patients received daily and increasing doses of insulin, rising to many hundreds of units, for a 6-week period.
openaire   +2 more sources

High-Fat Diet : Bacteria Interactions Promote Intestinal Inflammation Which Precedes and Correlates with Obesity and Insulin Resistance in Mouse [PDF]

, 2010
Background: Obesity induced by high fat (HF) diet is associated with inflammation which contributes to development of insulin resistance. Most prior studies have focused on adipose tissue as the source of obesity-associated inflammation.
Michael M Chi, Scott Magness, Jobin, Christian, Christian Jobin, Jobin Christian, Scull Brooks P., Brooks P. Scull, Lund Pauline K., Chi Michael M., Magness Scott, Shengli Ding, Pauline K Lund, Scull, Brooks P., Nicole M. J. Schwerbrock, Brooks P Scull, Nicole M J Schwerbrock, Chi, Michael M., Ding Shengli, Magness, Scott, Rigby Rachael, Schwerbrock, Nicole M. J., Schwerbrock Nicole M. J., Rigby, Rachael, Ding, Shengli, Lund, Pauline K., Michael M. Chi, Pauline K. Lund, Rachael Rigby   +27 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Difficulties of stable metabolic compensation of type 1 diabetes mellitus in adolescents

Лечащий Врач, 2021
The purpose of this report is to discuss the main factors that prevent the stable metabolic compensation of type 1 diabetes mellitus in adolescents, which must be taken into account in the management of the patient, the selection and control of therapy ...
E. B. Bashnina, I. M. Cargasova
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Psychological insulin resistance among patients with diabetes mellitus in Botswana

African Journal of Primary Health Care & Family Medicine
Background: Timely initiation of insulin therapy is vital in patients with type 2 diabetes mellitus. However, insulin initiation may be delayed because of psychological insulin resistance (PIR).
Engemadzo Bitsang, Billy M. Tsima, Keneilwe Motlhatlhedi   +2 more
doaj   +1 more source

Minimizing Hypoglycemia with Insulin Therapy: The “THINK” Strategy

Chronicle of Diabetes Research and Practice, 2022
Iatrogenic hypoglycemia is the most feared and common complication of insulin therapy. Hypoglycemia can have serious consequences and can be potentially life-threatening. In addition to the neurological manifestations of severe hypoglycemia, hypoglycemia
Gagan Priya, Emmy Grewal
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Influence of Insulin Pen Needle Geometry on Pain Perception and Patient’s Acceptability: A Review

Technologies
Diabetes is one of the most common diseases worldwide, with an increasing number of people affected. Insulin therapy is still the major treatment for both Type 1 and Type 2 diabetes and has evolved from bulky syringes to modern insulin pens introduced in
Francesca De Tommasi, Sergio Silvestri
doaj   +1 more source

Combination therapy in type 2 diabetes mellitus: adding empagliflozin to basal insulin

, 2015
Type 2 diabetes mellitus (T2DM) management is complex, with few patients successfully achieving recommended glycemic targets with monotherapy, most progressing to combination therapy, and many eventually requiring insulin. Sodium glucose cotransporter 2 (
Andrew Ahmann
core   +1 more source