Results 61 to 70 of about 29,062 (232)

Insulinoma apresentando-se como crise convulsiva: relato de caso Insulinoma presenting as seizure: case report

Arquivos de Neuro-Psiquiatria, 2005
O insulinoma é doença rara que cursa com sintomas episódicos neuroglicopênicos e/ou adrenérgicos. Descrevemos o caso de uma paciente de 36 anos, que estava sendo tratada por crises convulsivas parciais complexas há 4 anos sem melhora do quadro ...
Carlos Alexandre Twardowschy, Silmara Aparecida de Oliveira Leite, Tatiana Yukie Outi, Michelle Totti Dykyj   +3 more
doaj   +1 more source

Biomimetic MCC950‐loaded cerium‐layered double hydroxide nanoparticles for targeted treatment of Type 1 diabetes in streptozotocin‐induced mice

British Journal of Pharmacology, EarlyView.
The CLMBM nanoparticle (NP) system demonstrates strong and targeted anti‐ROS, antiapoptotic and anti‐inflammatory properties within the pancreas, thereby inhibiting the onset and progression of type 1 diabetes. Background and Purpose The destruction of β‐cells in type 1 diabetes is driven by signalling cascades that ultimately lead to cell apoptosis ...
Huiwen Pang, Zhuo Chen, Youzhi Wu, Thanh‐Truc Nguyen, Jingjing Wang, David M. Klyne, Zhi Ping Xu, Chen Chen, Alan Rowan, Felicity Y. Han   +9 more
wiley   +1 more source

Hipoglucemia e insulinoma

Revista Mexicana de Endocrinología, Metabolismo y Nutrición, 2022
La hipoglucemia persistente causada por un insulinoma es una patología poco frecuente que requiere un diagnóstico bioquímico y localización regional del tumor ante la sospecha para un tratamiento adecuado.
Isabel Pulgar-Sedó, Elizabeth Salsavilca, Dioni Gárate-Chirinos, Juan C. Lizarzaburu-Robles   +3 more
doaj   +1 more source

Determination of islet cell antibodies using an ELISA system with a preparation of rat insulinoma (RIN A2) cells [PDF]

, 1989
An enzyme-linked immunosorbent assay (ELISA) was established for the detection of islet cell antibodies in human sera. The antigen was prepared from rat insulinoma (RIN A2) cells.
Böhm, Bernhard Otto, Hedderich, U., Pfeiffer, Ernst Friedrich, Scherbaum, Werner A., Seißler, Jochen, Specker, M.   +5 more
core  

Advancing Early‐Stage Type 1 Diabetes Care: Future Focused Pathways for Identification, Screening, Diagnosis, and Monitoring

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Although international guidelines provide recommendations for screening and monitoring of early‐stage type 1 diabetes (T1D), navigating the care pathway can still be difficult for individuals, caregivers, and healthcare professionals (HCPs). These challenges are exacerbated by variations in healthcare systems, gaps in communication,
Chantal Mathieu, Valentino Cherubini, Thomas Kapellen, Noemí González Pérez de Villar, Guendalina Graffigna, Alix Besancon, Alfred Penfornis, Justin Gregory, Monica Bertolini, Maria Asunción Martinez‐Brocca, Korey Hood, Tabitha Randell, Ralph Ziegler, Parth Narendran, Carla Demeterco‐Berggren   +14 more
wiley   +1 more source

Life‐threatening acute complications persist among individuals with type 1 diabetes in Japan: A nationwide registry‐based cross‐sectional study

Journal of Diabetes Investigation, EarlyView.
Despite insulin therapy, 18.8 and 7.8% of the patients experienced diabetic ketosis and diabetic ketoacidosis, respectively. Furthermore, 12.7 and 28.9% of the participants experienced severe hypoglycemia and hypoglycemic unawareness, respectively. Lower C‐peptide levels were associated with the incidence of these complications.
Daisuke Chujo, Akihisa Imagawa, Junnosuke Miura, Kazuma Takahashi, Toru Kikuchi, Ichiro Horie, Daisuke Yabe, Akira Shimada   +7 more
wiley   +1 more source

Combined biological therapy with lanreotide autogel and cabergoline in the treatment of MEN-1-related insulinomas. [PDF]

, 2014
Multiple endocrine neoplasia type 1 (MEN1) is a hereditary syndrome associated with the development of many endocrine tumors, involving mainly pituitary, parathyroids, pancreas, although a proliferative state interests all neuroendocrine system.
Camera, L, Carratù, A, Colao, A, de Luca di Roseto, C, Del Prete, M, Di Somma, C, Faggiano, A., Marciello, F, Marotta, V, Ramundo, V   +9 more
core   +1 more source

Differential Pathophysiological Drivers of Susceptibility to Type 2 Diabetes and Metabolic Dysfunction–Associated Steatotic Liver Disease: Ethnic Differences in Insulin Dynamics, Whole‐Body Fat Metabolism, and Organ‐Specific Lipid Deposition

Obesity Reviews, EarlyView.
ABSTRACT Introduction This narrative review explores the epidemiological evidence and potential underlying pathophysiological defects underlying the disproportionately greater risk of Type 2 diabetes (T2D) and cardiometabolic disease in people of South Asian and African Caribbean ancestry compared with White Europeans.
Daniel J. Cuthbertson, Martin Whyte, Alex E. Henney, Uazman Alam, Louise Goff, Barbara A. Fielding, A. Margot Umpleby   +6 more
wiley   +1 more source

Jagn1 Is Induced in Response to ER Stress and Regulates Proinsulin Biosynthesis. [PDF]

PLoS ONE, 2016
The Jagn1 protein was indentified in a SILAC proteomic screen of proteins that are increased in insulinoma cells expressing a folding-deficient proinsulin.
Courtney Nosak, Pamuditha N Silva, Pietro Sollazzo, Kyung-Mee Moon, Tanya Odisho, Leonard J Foster, Jonathan V Rocheleau, Allen Volchuk   +7 more
doaj   +1 more source

Pro-inflammatory cytokines attenuate glucose-stimulated insulin secretion from INS-1E insulinoma cells by restricting mitochondrial pyruvate oxidation capacity - Novel mechanistic insight from real-time analysis of oxidative phosphorylation. [PDF]

, 2018
Pro-inflammatory cytokines cause pancreatic beta cell failure during the development of type 2 diabetes. This beta cell failure associates with mitochondrial dysfunction, but the precise effects of cytokines on mitochondrial respiration remain unclear ...
Affourtit, C, Barlow, J, Solomon, TPJ
core   +3 more sources