Results 81 to 90 of about 30,427 (262)

The Therapeutic Potential of Andrographolide and Its Derivatives in Inflammatory Diseases

open access: yesPharmacology Research &Perspectives, Volume 13, Issue 5, October 2025.
ABSTRACT Andrographolide, a diterpenoid component found in traditional Chinese medicine Andrographis paniculata, is known as a natural antibiotic and can be used to treat inflammatory lesions of various systemic diseases. In recent years, andrographolide derivatives have been continuously synthesized and have shown good anti‐inflammatory ...
Xiaoqin Shan   +7 more
wiley   +1 more source

Succinylated Gelatin Improves the Theranostic Potential of Radiolabeled Exendin-4 in Insulinoma Patients

open access: yesJournal of Nuclear Medicine, 2018
Being highly expressed in insulinomas, the glucagonlike peptide-1 receptor (GLP-1R) is a potential target for diagnosis, localization, and treatment with the radiolabeled GLP-1R agonist exendin.
M. Buitinga   +11 more
semanticscholar   +1 more source

Chromosome‐Level Genome Assembly of the Loach Goby Rhyacichthys aspro Offers Insights Into Gobioidei Evolution

open access: yesMolecular Ecology Resources, Volume 25, Issue 7, October 2025.
ABSTRACT The percomorph fish clade Gobioidei is a suborder that comprises over 2200 species distributed in nearly all aquatic habitats. To understand the genetics underlying their species diversification, we sequenced and annotated the genome of the loach goby, Rhyacichthys aspro, an early‐diverging group, and compared it with nine additional Gobioidei
Tzi‐Yuan Wang   +10 more
wiley   +1 more source

Perioperative use and accuracy of continuous glucose monitoring: A systematic review

open access: yesDiabetes, Obesity and Metabolism, Volume 27, Issue 10, Page 5393-5408, October 2025.
Abstract Perioperative impairment of glycaemic control significantly increases the risk of major postoperative complications. The use of continuous glucose monitoring (CGM) has demonstrated benefits in glycaemic control, but its use in the perioperative period remains unclear. The aim is to present the state of the art in the use and accuracy of CGM in
Léa Carlier   +5 more
wiley   +1 more source

Surgical treatment of insulinoma

open access: yesJournal of British Surgery, 1994
Abstract The role of preoperative and intraoperative procedures for the localization of insulinoma has been extensively debated. Transhepatic portal vein sampling before surgery has been recommended when other tests fail to localize the tumour.
Pedrazzoli S.   +2 more
openaire   +6 more sources

Binding kinetics, bias, receptor internalization and effects on insulin secretion in vitro and in vivo of a novel GLP‐1R/GIPR dual agonist, HISHS‐2001

open access: yesDiabetes, Obesity and Metabolism, Volume 27, Issue 10, Page 5938-5949, October 2025.
Abstract Aims The use of incretin analogues has emerged as an effective approach to achieve both enhanced insulin secretion and weight loss in Type 2 diabetes (T2D) patients. Agonists which bind and stimulate multiple receptors have shown particular promise.
Yusman Manchanda   +11 more
wiley   +1 more source

Diagnostic challenges in a patient with an occult insulinoma:68 Ga‐DOTA‐exendin‐4 PET/CT and 68Ga‐DOTATATE PET/CT

open access: yesClinical Case Reports, 2018
Despite growing evidence for GLP‐1R molecular‐based imaging, successful localization of insulinomas may require the use of multiple imaging modalities. Not all benign insulinomas express the GLP‐1R as expected. Our case demonstrates that there is a still
Elisa K. Bongetti   +6 more
semanticscholar   +1 more source

Clinical outcomes of gastroenteropancreatic neuroendocrine neoplasms in Taiwan: A multicenter registry study—TCOG T1214 study

open access: yesCancer, Volume 131, Issue 17, 1 September 2025.
Abstract Background Gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) account for more than 50% of all NENs. The survival of patients with GEP‐NENs has improved based on early diagnosis and improved treatment strategies. The real‐world data of GEP‐NENs in Taiwan are limited.
Hui‐Jen Tsai   +19 more
wiley   +1 more source

The utility of next‐generation sequencing in metastatic prostate cancer FNA biopsies

open access: yesCancer Cytopathology, Volume 133, Issue 9, September 2025.
ABSTRACT Background Current American Society of Clinical Oncology guidelines state that patients with metastatic prostate cancer (MPC) should undergo germline and somatic DNA sequencing. The authors examined the utility of next‐generation sequencing (NGS) on fine‐needle aspiration (FNA) biopsies in which NGS was performed on cell block (CB) and/or ...
Deepika Sirohi   +7 more
wiley   +1 more source

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