Results 91 to 100 of about 20,971 (292)
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Abstract and Applied Analysis, 2014 Based on zero curvature equations from semidirect sums of Lie algebras, we construct tri-integrable couplings of the Giachetti-Johnson (GJ) hierarchy of soliton equations and establish Hamiltonian structures of the resulting tri-integrable couplings by ...
Lei Wang, Ya-Ning Tang
doaj +1 more source
Advances in Difference Equations, 2019 In this paper, we mainly give the Lie algebras E, F and H of three kinds and their commutator, respectively. Next, we establish three isospectral problems with the help of their corresponding loop algebras Ẽ, F̃, and H̃.
Yuan Wei, Li Yin, Xin Long
doaj +1 more source
The model equation of soliton theory
, 2007 We consider an hierarchy of integrable 1+2-dimensional equations related to Lie algebra of the vector fields on the line. The solutions in quadratures are constructed depending on $n$ arbitrary functions of one argument.
A. B. Shabat +8 more
core +1 more source
Nonassociativity and Integrable Hierarchies
, 2005 Let A be a nonassociative algebra such that the associator (A,A^2,A) vanishes. If A is freely generated by an element f, there are commuting derivations delta_n, n=1,2,..., such that delta_n(f) is a nonlinear homogeneous polynomial in f of degree n+1. We prove that the expressions delta_{n_1} ...
Dimakis, Aristophanes +1 more
openaire +2 more sources
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Journal of High Energy Physics, 2019 We present a new set of boundary conditions for General Relativity on AdS3, where the dynamics of the boundary degrees of freedom are described by two independent left and right members of the Gardner hierarchy of integrable equations, also known as the “
Emilio Ojeda, Alfredo Pérez
doaj +1 more source
Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron +5 more
wiley +1 more source
The higher grading structure of the WKI hierarchy and the two-component short pulse equation
, 2012 A higher grading affine algebraic construction of integrable hierarchies, containing the Wadati-Konno-Ichikawa (WKI) hierarchy as a particular case, is proposed.
Franca, G. S. +2 more
core +1 more source
Whole‐Body Pattern of Muscle Degeneration and Progression in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterize whole‐body intramuscular fat distribution pattern in patients with sarcoglycanopathies and explore correlations with disease severity, duration and age at onset. Methods Retrospective, cross‐sectional, multicentric study enrolling patients with variants in one of the four sarcoglycan genes who underwent whole‐body ...
Laura Costa‐Comellas +39 more
wiley +1 more source