Results 71 to 80 of about 326 (216)
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
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Abstract and Applied Analysis, 2014 Based on zero curvature equations from semidirect sums of Lie algebras, we construct tri-integrable couplings of the Giachetti-Johnson (GJ) hierarchy of soliton equations and establish Hamiltonian structures of the resulting tri-integrable couplings by ...
Lei Wang, Ya-Ning Tang
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Journal of High Energy Physics, 2019 We present a new set of boundary conditions for General Relativity on AdS3, where the dynamics of the boundary degrees of freedom are described by two independent left and right members of the Gardner hierarchy of integrable equations, also known as the “
Emilio Ojeda, Alfredo Pérez
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Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
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Symmetries and integrable systems
Fundamental ResearchSymmetry plays key roles in modern physics especially in the study of integrable systems because of the existence of infinitely many local and nonlocal generalized symmetries.
Sen-Yue Lou, Bao-Feng Feng
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Advances in Difference Equations, 2019 In this paper, we mainly give the Lie algebras E, F and H of three kinds and their commutator, respectively. Next, we establish three isospectral problems with the help of their corresponding loop algebras Ẽ, F̃, and H̃.
Yuan Wei, Li Yin, Xin Long
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Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito +14 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang +10 more
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Two Kinds of New Integrable Couplings of the Negative-Order Korteweg-de Vries Equation
Advances in Mathematical Physics, 2015 Based on some known loop algebras with finite dimensions, two different negative-order integrable couplings of the negative-order Korteweg-de Vries (KdV) hierarchy of evolution equations are generated by making use of the Tu scheme, from which the ...
Binlu Feng, Yufeng Zhang
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Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
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