Results 61 to 70 of about 371,670 (284)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Generating nonisospectral integrable hierarchies via a new scheme

Advances in Difference Equations, 2020
In the paper, an efficient and straightforward method for generating nonisospectral integrable hierarchies is introduced. It follows that we consider the application related to Lie algebra gl ( 3 ) $\operatorname{gl}(3)$ based on the method.
Haifeng Wang, Yufeng Zhang
doaj   +1 more source

Similarity Transformations and Nonlocal Reduced Integrable Nonlinear Schrödinger Type Equations

Mathematics, 2023
We present three reduced integrable hierarchies of nonlocal integrable nonlinear Schrödinger-type equations, starting from a given vector integrable hierarchy generated from a matrix Lie algebra of B type. The basic tool is the zero curvature formulation.
Li Cheng, Wen-Xiu Ma
doaj   +1 more source

Liouville Correspondences between Integrable Hierarchies [PDF]

Symmetry, Integrability and Geometry: Methods and Applications, 2017
In this paper, we study explicit correspondences between the integrable Novikov and Sawada-Kotera hierarchies, and between the Degasperis-Procesi and Kaup-Kupershmidt hierarchies. We show how a pair of Liouville transformations between the isospectral problems of the Novikov and Sawada-Kotera equations, and the isospectral problems of the Degasperis ...
Kang, J., Liu, X., Olver, P.J., Qu, C.
openaire   +4 more sources

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A Real Four-Component Integrable Extension of the Standard Kaup–Newell Hierarchy with Two Diagonal Blocks

Axioms
This paper aims to introduce a real four-component integrable extension of the complex Kaup–Newell soliton hierarchy. Following a general idea for extending the standard Kaup–Newell spectral matrix, we propose a specific matrix eigenvalue problem ...
Wen-Xiu Ma
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The Semidirect Sum of Lie Algebras and Its Applications to C-KdV Hierarchy

Abstract and Applied Analysis, 2014
By use of the loop algebra G-~, integrable coupling of C-KdV hierarchy and its bi-Hamiltonian structures are obtained by Tu scheme and the quadratic-form identity.
Xia Dong, Tiecheng Xia, Desheng Li
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source