Results 61 to 70 of about 20,971 (292)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Binary Nonlinearization of Lax pairs of Kaup-Newell Soliton Hierarchy

, 1996
Kaup-Newell soliton hierarchy is derived from a kind of Lax pairs different from the original ones. Binary nonlinearization procedure corresponding to the Bargmann symmetry constraint is carried out for those Lax pairs.
A. P. Fordy, B. Fuchssteiner, B. Q. Lu, C. P. Liu, C. W. Cao, C. W. Cao, D. J. Kaup, F. Magri, G. Z. Tu, G. Z. Tu, G. Z. Tu, H. Airault, M. Antonowicz, M. J. Ablowitz, Q. Ding, V. I. Arnold, W. -X. Ma, W. G. Zhang, W. X. Ma, W. X. Ma, W. X. Ma, W. X. Ma, Y. B. Zeng   +22 more
core   +1 more source

Generalized W-algebras and integrable hierarchies [PDF]

Physics Letters B, 1992
9 ...
Burroughs, N., de Groot, M., Hollowood, T., Miramontes, L.   +3 more
openaire   +4 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

The Semidirect Sum of Lie Algebras and Its Applications to C-KdV Hierarchy

Abstract and Applied Analysis, 2014
By use of the loop algebra G-~, integrable coupling of C-KdV hierarchy and its bi-Hamiltonian structures are obtained by Tu scheme and the quadratic-form identity.
Xia Dong, Tiecheng Xia, Desheng Li
doaj   +1 more source

Completion of the Ablowitz-Kaup-Newell-Segur integrable coupling

, 2017
Integrable couplings are associated with non-semisimple Lie algebras. In this paper, we propose a new method to generate new integrable systems through making perturbation in matrix spectral problems for integrable couplings, which is called the ...
Jin, Yongyang, Li, Chunxia, Ma, Wen-Xiu, Shen, Shoufeng   +3 more
core   +1 more source

A System with Two Integrable Hierarchies [PDF]

Journal of the Physical Society of Japan, 1999
Summary: By assuming the symmetry group and using the inverse method, we find an integrable system which is constructed from superposition of two hierarchies of integrable equations. The authors discuss the SU(2) and SL(2,\(\mathbb{R}\)) cases in detail.
Imai, Koji, Konno, Kimiaki, Kakuhata, Hiroshi   +2 more
openaire   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source