Results 91 to 100 of about 1,512,981 (300)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

A specialised binary constraint for the stable marriage problem [PDF]

open access: yes, 2005
We present a specialised binary constraint for the stable marriage problem. This constraint acts between a pair of integer variables where the domains of those variables represent preferences. Our constraint enforces stability and disallows bigamy. For a
Unsworth, C.   +3 more
core   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

open access: yesMolecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Approximations of the set of trajectories, attainable sets, and integral funnel of a control system with integral and geometric constraints on the control functions

open access: yesElectronic Journal of Differential Equations
This article studies approximations to the set of trajectories, attainable sets and integral funnel of a control system described by an ordinary differential equation.
Anar Huseyin   +2 more
doaj  

Modeling of dynamics processes and dynamics control

open access: yesҚарағанды университетінің хабаршысы. Математика сериясы
Equations and methods of classical mechanics are used to describe the dynamics of technical systems containing elements of various physical nature, planning and management tasks of production and economic objects.
Р.Г. Мухарлямов   +1 more
doaj   +1 more source

Integrity constraints in graph databases

open access: yesProcedia Computer Science, 2017
Abstract: One thing that is still being developed for graph databases is integrity constraint (IC) support. One possibility to IC proposal is to consider a graph conceptual schema and a graph database schema. At least inherent ICs coming from a graph conceptual schema should be considered as explicit ICs on the graph databases level, i.e., using a ...
Jaroslav Pokorný   +2 more
openaire   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Discretisations, Constraints and Diffeomorphisms in Quantum Gravity

open access: yesSymmetry, Integrability and Geometry: Methods and Applications, 2012
In this review we discuss the interplay between discretization, constraint implementation, and diffeomorphism symmetry in Loop Quantum Gravity and Spin Foam models. To this end we review the Consistent Discretizations approach, which is an application of
Benjamin Bahr   +2 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Checking the Integrity of Spatial Integrity Constraints

open access: yes, 2007
Integrity constraints play a major role when the quality of spatial data is checked by automatic procedures. Nevertheless the possibilities of checking the internal consistency of the integrity constraints themselves are hardly researched jet. This work analyses the applicability of reasoning techniques like the composition of spatial relations and ...
openaire   +4 more sources

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