Results 71 to 80 of about 502,946 (294)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Path-integral over non-linearly realized groups and Hierarchy solutions [PDF]

, 2007
The technical problem of deriving the full Green functions of the elementary pion fields of the nonlinear sigma model in terms of ancestor amplitudes involving only the flat connection and the nonlinear sigma model constraint is a very complex task.
A. Quadri, A. Quadri, A. Quadri, A. Quadri, Andrea Quadri, D. Bettinelli, Daniele Bettinelli, E.C.G. Stückelberg, O. Piguet, R. Ferrari, R. Ferrari, R. Ferrari, Ruggero Ferrari   +12 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The path integral measure, constraints and ghosts for massive gravitons with a cosmological constant

, 2009
For massive gravity in a de Sitter background one encounters problems of stability when the curvature is larger than the graviton mass. I analyze this situation from the path integral point of view and show that it is related to the conformal factor ...
Dimitrios Metaxas, N. Arkani-Hamed, V. I. Zakharov   +2 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The Phoenix Project: Master Constraint Programme for Loop Quantum Gravity

, 2003
The Hamiltonian constraint remains the major unsolved problem in Loop Quantum Gravity (LQG). Seven years ago a mathematically consistent candidate Hamiltonian constraint has been proposed but there are still several unsettled questions which concern the ...
Ambjorn J Jurkiewicz J Loll R, Antonsen F Markopoulou F, Arnol'd V I, Arnol'd V I, Ashtekar A, Ashtekar A, Ashtekar A, Ashtekar A, Ashtekar A, Ashtekar A Bojowald M Lewandowski J, Ashtekar A Fairhurst S Willis J L, Ashtekar A Lewandowski J Sahlmann H, Baez J C, Baez J C, Baez J C, Barrett J W, Biggs N, Bojowald M, Bojowald M, Bojowald M, Bojowald M, Bojowald M Perez A, Borissov R, Brunnemann J, Brunnemann J Giesel K Thiemann T, Brunnemann J Thiemann T, Carlip S, Cornfeld I P, Deser S, Deser S, Di Bartolo C, Di Bartolo C, Di Bartolo C, Dittrich B, Dittrich B, Dittrich B, Dittrich B, Dittrich B, Dittrich B Thiemann T, Dittrich B Thiemann T, Gambini R, Gambini R, Gambini R Porto R A Pullin J, Gambini R Pullin J, Gambini R Pullin J, Gaul M, Gel'fand I M, Giulini D, Giulini D, Glimm J, Klauder J, Lewandowski J, Loll R, Loll R, Markopoulou F, Markopoulou F, Okolow A Lewandowski J, Perez A, Renteln P, Rovelli C, Rovelli C, Sahlmann H Thiemann T, Sahlmann H Thiemann T, Sahlmann H Thiemann T, Sahlmann H Thiemann T, Smolin L, T Thiemann, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Thirring W   +83 more
core   +2 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Boundary value problems with an integral constraint

Electronic Journal of Differential Equations, 2015
We show the existence of solutions for a second-order ordinary differential equation coupled with a boundary-value condition and an integral condition.
Elisabetta M. Mangino, Eduardo Pascali
doaj  

Integrated chance constraints

, 2002
We consider integrated chance constraints (ICC), which provide quantitative alternatives for traditional chance constraints. We derive explicit polyhedral descriptions for the convex feasible sets induced by ICCs, for the case that the underlying distribution is discrete.
Haneveld, Willem K. Klein, Vlerk, Maarten H. van der   +1 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source