Results 71 to 80 of about 1,512,981 (300)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
On updates with integrity constraints
, 2005 In his paper ``Making Counterfactual Assumptions'' Frank Veltman has proposed a new semantics for counterfactual conditionals. It is based on a particular update operation, and we show that it provides a new and interesting way of updating logical databases under integrity constraints which generalizes in particular Winslett's PMA.
openaire +4 more sources
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Boundary value problems with an integral constraint
Electronic Journal of Differential Equations, 2015 We show the existence of solutions for a second-order ordinary differential equation coupled with a boundary-value condition and an integral condition.
Elisabetta M. Mangino, Eduardo Pascali
doaj
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Integral constraints in multiple scales problems with a slowly varying microstructure
European Journal of Applied MathematicsAsymptotic homogenisation is considered for problems with integral constraints imposed on a slowly varying microstructure; an insulator with an array of perfectly dielectric inclusions of slowly varying size serves as a paradigm.
Amy Kent +3 more
doaj +1 more source
Volterra integral equations and fractional calculus: Do neighbouring solutions intersect? [PDF]
, 2012 This is the author's PDF version of an article published in Journal of Integral Equations and Applications. The definitive version is available at rmmc.asu.edu/jie/jie.html.This journal article considers the question of whether or not the solutions to ...
Diethelm, Kai, Ford, Neville J.
core +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
H∞ Optimal Performance Design of an Unstable Plant under Bode Integral Constraint
Complexity, 2018 This paper proposed the H∞ state feedback and H∞ output feedback design methods for unstable plants, which improved the original H∞ state feedback and H∞ output feedback.
Fanwei Meng +4 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source