Results 71 to 80 of about 1,573,513 (300)

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

A study of encodings of constraint satisfaction problems with 0/1 variables [PDF]

, 2003
Many constraint satisfaction problems (csp's) are formulated with 0/1 variables. Sometimes this is a natural encoding, sometimes it is as a result of a reformulation of the problem, other times 0/1 variables make up only a part of the problem. Frequently
Selensky, E., Prosser, P.
core   +3 more sources

Boundary value problems with an integral constraint

Electronic Journal of Differential Equations, 2015
We show the existence of solutions for a second-order ordinary differential equation coupled with a boundary-value condition and an integral condition.
Elisabetta M. Mangino, Eduardo Pascali
doaj  

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Integral constraints in multiple scales problems with a slowly varying microstructure

European Journal of Applied Mathematics
Asymptotic homogenisation is considered for problems with integral constraints imposed on a slowly varying microstructure; an insulator with an array of perfectly dielectric inclusions of slowly varying size serves as a paradigm.
Amy Kent, Sarah L. Waters, James M. Oliver, Stephen Jonathan Chapman   +3 more
doaj   +1 more source

On updates with integrity constraints

, 2005
In his paper ``Making Counterfactual Assumptions'' Frank Veltman has proposed a new semantics for counterfactual conditionals. It is based on a particular update operation, and we show that it provides a new and interesting way of updating logical databases under integrity constraints which generalizes in particular Winslett's PMA.
openaire   +4 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Mixing Visual and Textual Constraint Languages [PDF]

, 1999
The Object Constraint Language (OCL) is a precise language for notating behavioural constraints on UML models. Constraint diagrams have been proposed as a means of notating similar constraints, but in a visual form.
Howse, John, Stuart Kent, John Howse, Kent, Stuart, Andrade, Luis Filipe, Fiadeiro, José Luiz   +5 more
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source