Results 121 to 130 of about 134,491 (310)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Two Operator Boundary - Domain Integral Equations for variable coefficient Neumann BVP in 2D
, 2020 Tsegaye G. Ayele, Solomon Bekele
openalex +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Identification and Characterization of Golgin-84, a Novel Golgi Integral Membrane Protein with a Cytoplasmic Coiled-coil Domain [PDF]
, 1999 R.A. Bascom +2 more
openalex +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Numerical simulation of fluid flow with a fast Boundary‐Domain Integral Method [PDF]
, 2023 J. Tibaut, Jure Ravnik, Martin Schanz
openalex +1 more source
Duality in Noetherian Integral Domains
Rocky Mountain Journal of Mathematics, 1999 Let \(A\) be a torsion-free abelian group of rank one and let \(C(A)\) denote the class of torsion-free abelian groups \(M\) of finite rank such that \(M\) embeds as \(\text{End}(A)\)-submodule of \(A^n\) for some \(n\). Then the map \(M\) to \(\Hom(M,A)\) on \(C(A)\) defines a duality. This is called Warfield duality. In this paper, the author gives a
openaire +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
On Generalized k-Uniformly Close-to-Convex Functions of Janowski Type
International Journal of Analysis and Applications, 2019 This work is concerned with the class of analytic functions that maps open unit disk onto conic domains. Necessary condition, arc length, growth rate of coefficients, radius problems and property of some integral transformation under the class are ...
Afis Saliu
doaj +2 more sources