Results 51 to 60 of about 157,958 (265)
Ciências Sociais Unisinos, 2019 The article focuses on the symbolic matrix that underlies an Integral Education Program idealized by business elites, which is currently disseminated throughout Brazil by the agency of nonprofit organizations linked to the corporate realm, in ...
Miqueli Michetti
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Integral Education in Light of Earthrise [PDF]
Integral Review, 2015 This article explores the relationship between integral education and the emerging terrestrial consciousness—a consciousness of interdependency, sovereignty, and earthly responsibility.
Craig Chalquist
doaj
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Sophiology as an Example of Integral Science and Education in the Slavonic Tradition
Spirituality Studies, 2015 Several thinkers among the Slavs and in the Orthodox East have been led by the vision of Sophia – integral wisdom. Sophiology is an effort to integrate different sources of knowledge: revelation, reason and sensory experience.
Emil Páleš
doaj
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Integration Processes in Education: Classification of Integration Types
Review of European Studies, 2015 © 2015, Review of European Studies. All right reserved. The relevance of the stated problem is due to the fact that integration is a system formation that combines procedural and resulting components contributing to the appearance of a system’s new integrative quality, which cannot be reduced to the sum of the qualities of its autonomous elements.
Shaidullina A. +6 more
openaire +5 more sources
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source