Results 121 to 130 of about 4,481,393 (334)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Solutions of Non-Integrable Equations by the Hirota Direct Method [PDF]

open access: yesarXiv, 2006
We show that we can also apply the Hirota method to some non-integrable equations. For this purpose, we consider the extensions of the Kadomtsev-Petviashvili (KP) and the Boussinesq (Bo) equations. We present several solutions of these equations.
arxiv  

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

open access: yesMolecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson   +11 more
wiley   +1 more source

Integrable hyperbolic equations of sin-Gordon type [PDF]

open access: yesarXiv, 2009
A complete list of nonlinear one-field hyperbolic equations having generalized integrable x- and y-symmetries of the third order is presented. The list includes both sin-Gordon type equations and equations linearizable by differential substitutions.
arxiv  

Numerical solution of singular integro-differential Prandtl equation by the method of orthogonal polynomials

open access: yesЖурнал Белорусского государственного университета: Математика, информатика, 2019
The paper is constructed and proved computational scheme for a solution of singular Prandtl of integro-differential  equations with singular integral over the interval of the real axis, understood in the sense of the Cauchy principal value.
Galina A. Rasolko
doaj  

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

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