Results 101 to 110 of about 150,190 (315)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Analysis of some localized boundary-domain integral equations

, 2009
Some direct segregated localized boundary-domain integral equation (LBDIE) systems associated with the Dirichlet and Neumann boundary value problems (BVP) for a scalar "Laplace" PDE with variable coefficient are formulated and analysed. The parametrix is
Mikhailov, SE, Natroshvili, D, Chkadua, O   +2 more
core  

Numerics of boundary-domain integral and integro-differential equations for BVP with variable coefficient in 3D

, 2013
This is the post-print version of the article. The official published version can be accessed from the links below - Copyright @ 2013 Springer-VerlagA numerical implementation of the direct boundary-domain integral and integro-differential equations ...
Mikhailov, SE, Rjasanow, S, Grzhibovskis, R   +2 more
core   +1 more source

Triviality of the 2D stochastic Allen-Cahn equation [PDF]

, 2012
We consider the stochastic Allen-Cahn equation driven by mollified space-time white noise. We show that, as the mollifier is removed, the solutions converge weakly to 0, independently of the initial condition.
H. Weber, Martin Hairer, Hairer, Martin, Marc D. Ryser, M. Hairer, Hendrik Weber, Weber, Hendrik, M. D. Ryser, Ryser, Marc D.   +8 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Angle-dependent integral equation theory improves results of thermodynamics and structure of rose water model. [PDF]

J Chem Phys, 2023
Ogrin P, Urbic T.
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

On the convergence of the hp-BEM with quasi-uniform meshes for the electric field integral equation on polyhedral surfaces

, 2008
In this paper the hp-version of the boundary element method is applied to the electric field integral equation on a piecewise plane (open or closed) Lipschitz surface. The underlying meshes are supposed to be quasi-uniform.
Bespalov, A, Heuer, N
core  

Localized boundary-domain singular integral equations based on harmonic parametrix for divergence-form elliptic PDEs with variable matrix coefficients

, 2013
This is the post-print version of the Article. The official publised version can be accessed from the links below. Copyright @ 2013 Springer BaselEmploying the localized integral potentials associated with the Laplace operator, the Dirichlet, Neumann and
Mikhailov, SE, Natroshvili, D, Chkadua, O   +2 more
core   +1 more source

A Super-Algebraically Convergent, Windowing-Based Approach to the Evaluation of Scattering from Periodic Rough Surfaces [PDF]

, 2008
We introduce a new second-kind integral equation method to solve direct rough surface scattering problems in two dimensions. This approach is based, in part, upon the bounded obstacle scattering method that was originally presented in Bruno et al. [2004]
Monro, John Anderson
core   +1 more source