Results 121 to 130 of about 150,190 (315)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Convergence of a collocation scheme for a retarded potential integral equation

open access: yes, 2003
Time domain boundary integral formulations of transient scattering problems involve retarded potential integral equations (RPIEs). Solving such equations numerically is both complicated and computationally intensive, and numerical methods often prove to ...
Duncan, D.B.
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Mixed type of Fredholm-Volterra integral equation

open access: yesLe Matematiche, 2005
In this paper, under certain conditions, the solution of mixed type of Fredholm-Volterra integral equation is discussed and obtained in the space L_2 (−1, 1) × C[0, T ], T < ∞.
M. A. Abdou, G. M. Abd Al-Kader
doaj  

Solvability of an Integral Equation of Volterra-Wiener-Hopf Type

open access: yesAbstract and Applied Analysis, 2014
The paper presents results concerning the solvability of a nonlinear integral equation of Volterra-Stieltjes type. We show that under some assumptions that equation has a continuous and bounded solution defined on the interval 0,∞ and having a finite ...
Nurgali K. Ashirbayev   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Asymptotic behaviour at infinity of solutions of second kind integral equations on unbounded regions of Rn

open access: yes, 1994
We consider second kind integral equations of the form x(s) - (abbreviated x - K x = y ), in which Ω is some unbounded subset of Rn. Let Xp denote the weighted space of functions x continuous on Ω and satisfying x (s) = O(|s|-p ),s → ∞We show that if the
Peplow, AT   +3 more
core  

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