Results 81 to 90 of about 1,317,953 (283)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

An Algorithm for the Solution of Integro-Fractional Differential Equations with a Generalized Symmetric Singular Kernel

Fractal and Fractional
This work studies an integro-fractional differential equation (I-FrDE) with a generalized symmetric singular kernel. The scientific approach in this study was to transform the integro-differential equation (I-DE) into a mixed integral equation (MIE) with
Sameeha A. Raad, Mohammed A. Abdou
doaj   +1 more source

Constructive method for solvability of Fredholm equation of the first kind

Electronic Journal of Qualitative Theory of Differential Equations, 2017
The solvability and construction of the general solution of the first kind Fredholm integral equation are among the insufficiently explored problems in mathematics. There are various approaches to solve this problem.
Serikbai Aisagaliev, Zhanat Zhunussova
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Fredholm-Volterra integral equation with potential kernel

International Journal of Mathematics and Mathematical Sciences, 2001
A method is used to solve the Fredholm-Volterra integral equation of the first kind in the space L2(Ω)×C(0,T), Ω={(x,y):x2+y2≤a}, z=0, and ...
M. A. Abdou, A. A. El-Bary
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A solution of 3D Helmholtz equation for boundary geometry modeled by Coons patches using the Parametric Integral Equation System

Archives of Acoustics, 2014
In this paper, the authors propose an algorithm for numerical solution of the 3D Helmholtz equation using the Parametric Integral Equation System (PIES). The PIES, unlike the traditional Boundary Integral Equation (BIE), is characterized by the fact that
E. ZIENIUK, K. SZERSZEŃ
doaj  

Existence of periodic traveling wave solutions to the generalized forced Boussinesq equation

International Journal of Mathematics and Mathematical Sciences, 1999
The generalized forced Boussinesq equation, utt−uxx+[f(u)]xx+uxxxx=h0, and its periodic traveling wave solutions are considered. Using the transform z=x−ωt, the equation is converted to a nonlinear ordinary differential equation with periodic boundary ...
Kenneth L. Jones, Yunkai Chen
doaj   +1 more source