Results 71 to 80 of about 1,317,953 (283)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
On the properties of the solution set map to Volterra integral inclusion
, 2017 For the multivalued Volterra integral equation defined in a Banach space, the set of solutions is proved to be $R_\delta$, without auxiliary conditions imposed in Theorem 6 [J. Math. Anal. Appl. 403 (2013), 643-666]. It is shown that the solution set map,
Pietkun, Radosław
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Integral equation theory for nematic fluids
Condensed Matter Physics, 2010 The traditional formalism in liquid state theory based on the calculation of the pair distribution function is generalized and reviewed for nematic fluids. The considered approach is based on the solution of orientationally inhomogeneous Ornstein-Zernike
M.F. Holovko
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Известия высших учебных заведений. Поволжский регион: Физико-математические науки, 2023 Background. The purpose of this work is to study the 3-D scalar problem of scattering a plane wave from an inhomogeneous solid covered with an infinitely thin layer of graphene. Material and methods.
Aleksey A. Tsupak
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LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Journal of Marine Science and EngineeringThe classical Neumann–Kelvin (NK) theory of potential flow around a free-surface-piercing ship that steadily advances in calm water or through regular waves is considered.
Francis Noblesse, Jiayi He
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