Results 61 to 70 of about 1,317,953 (283)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
The Two-Term Abel’s Integral Equation
Journal of Mathematical Extension, 2012 In this article we investigate the two-term Abel’s integral equations. We will do this in two different ways and show that such equation is reducible to an integro−differential equation of Volterra type.
F. M. Maalek Ghaini +2 more
doaj
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Optimal Control Problems of Forward-Backward Stochastic Volterra Integral Equations [PDF]
, 2014 Optimal control problems of forward-backward stochastic Volterra integral equations (FBSVIEs in short) are formulated and studied. A general duality principle is established for linear backward stochastic integral equation and linear stochastic Fredholm ...
Shi, Yufeng +2 more
core
Necessity of integral formalism
, 2011 To describe the physical reality, there are two ways of constructing the dynamical equation of field, differential formalism and integral formalism. The importance of this fact is firstly emphasized by Yang in case of gauge field [Phys. Rev. Lett.
+11 more
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
On the integral equation of an adjoint boundary value problem of heat conduction
Қарағанды университетінің хабаршысы. Математика сериясы, 2019 An integral equation is considered, to which a nonhomogeneous first boundary value problem with an adjoint heat conduction operator is reduced. The problem is set in an infinite plane angle, that is, a boundary of the domain moves with a constant ...
M.T. Kosmakova +4 more
doaj +1 more source
Exact integral equation for the renormalized Fermi surface
, 2002 The true Fermi surface of a fermionic many-body system can be viewed as a fixed point manifold of the renormalization group (RG). Within the framework of the exact functional RG we show that the fixed point condition implies an exact integral equation ...
+28 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source