Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Orthonormal Bernoulli Polynomials for Solving a Class of Two Dimensional Stochastic Volterra-Fredholm Integral Equations. [PDF]
Int J Appl Comput Math, 2022 Pourdarvish A +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
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Dynamic Risk Measures for Anticipated Backward Doubly Stochastic Volterra Integral Equations. [PDF]
Entropy (Basel), 2021 Miao L, Liu Z, Hu Y.
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Stochastic dynamic equations on general time scales
Electronic Journal of Differential Equations, 2013 In this article, we construct stochastic integral and stochastic differential equations on general time scales. We call these equations stochastic dynamic equations.
Martin Bohner +2 more
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Approximate solutions to several classes of Volterra and Fredholm integral equations using the neural network algorithm based on the sine-cosine basis function and extreme learning machine. [PDF]
Front Comput Neurosci, 2023 Lu Y, Zhang S, Weng F, Sun H.
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Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
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Modeling evidence accumulation decision processes using integral equations: Urgency-gating and collapsing boundaries. [PDF]
Psychol Rev, 2022 Smith PL, Ratcliff R.
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source