Results 141 to 150 of about 108,806 (312)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Positive solutions of systems of perturbed Hammerstein integral equations with arbitrary order dependence. [PDF]
Philos Trans A Math Phys Eng Sci, 2021 Infante G.
europepmc +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Modified collocation-based numerical methods for Volterra Integral and Integro-Differential Equations [PDF]
, 2009 The aim of this talk is to present modified collocation based numerical methods for solving Volterra Integral and Integro-Differential Equations (VIEs and VIDEs respectively), which turn out to be at the heart of many modern applications of Mathematics ...
D'AMBROSIO, RAFFAELE +3 more
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Results in Applied MathematicsThis work considers the optimal quadrature formula in a Hilbert space for the numerical approximation of the integral equations. It discusses the sequence of solving integral equations with quadrature formulas.
Abdullo Hayotov, Samandar Babaev
doaj +1 more source
Integrability and Einstein׳s Equations
Integrable structures arise in general relativity when the spacetime possesses a pair of commuting Killing vectors admitting 2-spaces orthogonal to the group orbits. The physical interpretation of such spacetimes depends on the norm of the Killing vectors.
Korotkin, Dmitry, Samtleben, Henning
openaire +2 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Boundary integral equations on unbounded rough surfaces: Fredholmness and the finite section method [PDF]
, 2008 We consider a class of boundary integral equations that arise in the study of strongly elliptic BVPs in unbounded domains of the form D = (x, z) ∈ Rn × R: z > f(x) where f: Rn → R is a sufficiently smooth bounded and continuous function.
Lindner, Marko, Chandler-Wilde, Simon N.
core
Positive solutions of Volterra integral equations using integral inequalities
Journal of Inequalities and Applications, 2002 The existence of positive solutions of certain special cases of the possibly singular Volterra integral equation is discussed, using Krasnoselskii's fixed point theorem.
O'regan Donal, Meehan Maria
doaj