Results 61 to 70 of about 1,037,243 (332)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Classical integrability in the BTZ black hole

, 2011
Using the fact the BTZ black hole is a quotient of AdS_3 we show that classical string propagation in the BTZ background is integrable. We construct the flat connection and its monodromy matrix which generates the non-local charges.
A Babichenko, Abhishake Sadhukhan, B Stefanski Jr, D Birmingham, D Serban, E Berti, E Witten, G Mandal, G Mandal, H Lin, I Bena, J Troost, JA Minahan, JM Maldacena, JR David, JR David, Justin R. David, K Ideguchi, LAP Zayas, M Bañados, M Kruczenski, M Kruczenski, N Beisert, N Cruz, P Basu, P Basu, R Dijkgraaf, S Frolov, SA Frolov, VA Kazakov, VA Kazakov, Y Satoh   +31 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Solutions of singular integral equations

International Journal of Mathematics and Mathematical Sciences, 1982
Qualitative behavior of solutions of possibly singluar integral equations is studied. It includes properties such as positivity, boundedness and monotonicity of the solutions of the infinite interval.
Rina Ling
doaj   +1 more source

Linear Integral Equations

, 1989
3
openaire   +4 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Hypersingular Integral Equations Encountered in Problems of Mechanics

Mathematics
In the paper, for hypersingular integral equations with new kernels, a solution is constructed using an approach based on Chebyshev orthogonal polynomials and the principle of contraction mappings.
Suren M. Mkhitaryan, Hovik A. Matevossian, Eghine G. Kanetsyan, Musheg S. Mkrtchyan   +3 more
doaj   +1 more source

Some Coincidence and Common Fixed-Point Results on Cone b 2 -Metric Spaces over Banach Algebras with Applications to the Infinite System of Integral Equations [PDF]

, 2021
Ziaul Islam, Muhammad Sarwar, Doaa Filali, Fahd Jarad   +3 more
openalex   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source