Results 111 to 120 of about 666,156 (322)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Unbounded Integral Hankel Operators

open access: yesFunctional Analysis and Its Applications
For a wide class of unbounded integral Hankel operators on the positive half-line, we prove essential self-adjointness on the set of smooth compactly supported functions.
Pushnitski, Alexander, Treil, Sergei
openaire   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

On the Convergence of the Approximate Solution to the Optimization Problem for Oscillatory Processes

open access: yesҚарағанды университетінің хабаршысы. Математика сериясы
This article addresses the non-linear optimization problem of oscillatory processes governed by partial integro-differential equations involving a Fredholm integral operator. A distinctive feature of the problem is that both the objective functional and
E.F. Abdyldaeva   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Starlikeness Properties of a New Integral Operator for Meromorphic Functions

open access: yesJournal of Applied Mathematics, 2011
We define here an integral operator ℋ𝛾1,…,𝛾𝑛 for meromorphic functions in the punctured open unit disk. Several starlikeness conditions for the integral operator ℋ𝛾1,…,𝛾𝑛 are derived.
Aabed Mohammed, Maslina Darus
doaj   +1 more source

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