Results 141 to 150 of about 31,065 (264)

INCT UroGen and the Transformation of Brazilian Urologic Oncology: A Model for Trans-lational Science and Health Equity. [PDF]

Int Braz J Urol
Reis LO, Trinh QD, Shariat S, Chamas R, Vallinoto ACR.   +4 more
europepmc   +1 more source

A novel embryo biopsy morphological analysis and genetic integrality criterion system significantly improves the outcome of preimplantation genetic testing. [PDF]

J Assist Reprod Genet, 2023
Kuo Y, Zhu X, Guo Q, Wang Y, Guan S, Liu P, Li R, Yan Z, Yan L, Qiao J.   +9 more
europepmc   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Trends and Geographical Distribution of Family Health Strategy in Brazil from 2009-2023. [PDF]

Healthcare (Basel)
Barbosa PHS, Sanches BS, do Espírito Santo MLDAC, Pabst H, Land MGP, de Souza HSP.   +5 more
europepmc   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Knowledge of nursing teachers about health promotion for the LGBTQIA+ population. [PDF]

Rev Esc Enferm USP
Farias GM, Martini JG, Vargas MAO.
europepmc   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

The crosstalk between fatty acid metabolism disorder and mitochondrial dysfunction is involved in hepatotoxicity co-induced by cadmium and molybdenum in ShaoXing duck (Anas platyrhyncha) livers. [PDF]

Poult Sci
Li S, Nie G, Dai X, Zhu J, Xiao L, Wang S, Chen J, Ren J, Zhang C.   +8 more
europepmc   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Accuracy of the ABFW ‒ Screening for speech disorders in early childhood. [PDF]

Braz J Otorhinolaryngol
Matsumoto MMN, da Silva BFA, Costa MLPO, Carneiro AA, Molini-Avejonas DR.   +4 more
europepmc   +1 more source