Results 71 to 80 of about 8,166 (301)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Implied Integrality in Mixed-Integer Optimization
Implied-integer detection is a well-known presolving technique that is used by many Mixed-Integer Linear Programming solvers. Informally, a variable is said to be implied integer if its integrality is enforced implicitly by integrality of other variables
van der Hulst, Rolf +1 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Improving integrality gaps via Chvátal-Gomory rounding
, 2010 In this work, we study the strength of the Chvátal-Gomory cut generating procedure for several hard optimization problems. For hypergraph matching on k-uniform hypergraphs, we show that using Chvátal-Gomory cuts of low rank can reduce the integrality ...
Mohit Singh, Kunal Talwar
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
An improved integrality gap for asymmetric TSP paths
, 2013 The Asymmetric Traveling Salesperson Path (ATSPP) problem is one where, given an asymmetric metric space (V,d) with specified vertices s and t, the goal is to find an s-t path of minimum length that passes through all the vertices in V.
Mohit Singh +2 more
core +2 more sources
Gravitational couplings in N $$ \mathcal{N} $$ = 2 heterotic compactifications with Wilson lines
Journal of High Energy Physics, 2020 In this paper we compute the gravitational couplings of the heterotic string compactified on (K3 × T 2)/ℤ N and E 8 × E 8 and predict the Gopakumar Vafa invariants of the dual Calabi Yau manifold in presence of Wilson lines.
Aradhita Chattopadhyaya
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
O sujeito autista na Rede SUS: (im)possibilidade de cuidado
Fractal: Revista de PsicologiaResumo O presente artigo visa apresentar um estudo teórico sobre os documentos oficiais e normativos do Ministério da Saúde em relação aos Transtornos do Espectro do Autismo (TEA). Partimos do objetivo de conhecer o discurso presente nesses documentos e,
Lucas Silveira da Silva +1 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source