BMC BiotechnologyBackground Mammalian display is an appealing technology for therapeutic antibody development. Despite the advantages of mammalian display, such as full-length IgG display with mammalian glycosylation and its inherent ability to select antibodies with ...
Olli Huhtinen +4 more
doaj +1 more source
Major antigenic region on the integrase (IN) protein of human immunodeficiency virus type 1 determined by reactivity of human sera and a monoclonal antibody to IN protein [PDF]
, 1994 Y Tachibana +5 more
openalex +1 more source
DASH: a versatile and high‐capacity gene stacking system for plant synthetic biology
Plant Biotechnology Journal, EarlyView.Summary DNA assembly systems based on the Golden Gate method are popular in synthetic biology but have several limitations: small insert size, incompatibility with other cloning platforms, DNA domestication requirement, generation of fusion scars, and lack of post‐assembly modification.
Chengsong Zhao +2 more
wiley +1 more source
Predicting Knot or Catenane Type of Site-Specific Recombination Products
, 2007 Site-specific recombination on supercoiled circular DNA yields a variety of knotted or catenated products. We develop a model of this process, and give extensive experimental evidence that the assumptions of our model are reasonable. We then characterize
Buck, Dorothy, Flapan, Erica
core +1 more source
Factors determining chromosomal localization of transposable elements in plants
Plant Biology, EarlyView.We review transposon chromosomal niches, and the functional consequences of their specific chromosomal localization in plants. Abstract Transposable elements (TEs) constitute a significant part of plant genomes and shape their genomic landscape. While some TEs are ubiquitously dispersed, other elements specifically occupy discrete genomic loci.
E. Kejnovsky +3 more
wiley +1 more source
Structure-based mutagenesis of the catalytic domain of human immunodeficiency virus type 1 integrase [PDF]
, 1997 Alan Engelman +4 more
openalex +1 more source
Detection of an integrase gene in clinical isolates of Mycobacterium tuberculosis
International Journal of Mycobacteriology, 2015 Introduction: Drug resistance in Mycobacterium tuberculosis (MTB) is caused by many mechanisms. Integrons are genetic units characterized by their ability to capture and incorporate bacterial genomes by recombination and may contain resistance-related ...
M Arjomandzadegan +3 more
doaj
The Plant Genome, Volume 18, Issue 3, September 2025.Abstract Cacao (Theobroma cacao), the source of chocolate, is threatened by devastating diseases like frosty pod rot (FPR) and witches' broom disease (WBD), impacting global production and farmer livelihoods. Here, we employ a machine learning‐driven genome‐wide association study to dissect the genetic architecture of disease resistance and ...
Ezekiel Ahn +9 more
wiley +1 more source
Human endogenous retrovirus K10 encodes a functional integrase [PDF]
, 1996 Yoshihiro Kitamura +4 more
openalex +1 more source
Factors Influencing the Binding of HIV‐1 Protease Inhibitors: Insights from Machine Learning Models
ChemMedChem, Volume 20, Issue 15, August 2, 2025.Machine learning unlocks the secrets of HIV‐1 protease inhibition, paving the way for data‐driven antiviral drug design. This study analyzes crystallographic data from hundreds of protein–ligand complexes, predicting ligand binding affinity with over 85% accuracy.
Yaffa Shalit, Inbal Tuvi‐Arad
wiley +1 more source