Results 141 to 150 of about 54,271 (286)

Significance of constitutive integrase synthesis. [PDF]

Proceedings of the National Academy of Sciences, 1976
One conceivable function for constitutive integrase formation by lambda prophage is to stabilize the inserted state by catalyzing reinsertion of prophages that are accidentally excised. As this hypothesis implies a dynamic equilibrium betwen inserted and noninserted DNA, the existence of such an equilibrium is explored.
openaire   +3 more sources

Addressing Cardiometabolic Challenges in HIV: Insights, Impact, and Best Practices for Optimal Management—A Narrative Review

Health Science Reports, Volume 8, Issue 4, April 2025.
ABSTRACT Introduction Since the advent of highly active antiretroviral therapy (HAART), morbidity and mortality rates associated with human immunodeficiency virus (HIV) have significantly decreased leading to prolonged life span of Individuals living with HIV due to the effectiveness of antiretroviral therapy.
Nadine Mugisha, Laura Ghanem, Omar A. I. Komi, Rawan Noureddine, Sanobar Shariff, Magda Wojtara, Mahlagha Mousavi Nanehkeran, Olivier Uwishema   +7 more
wiley   +1 more source

Insights into the Functions of a Prophage Recombination Directionality Factor

Viruses, 2012
Recombination directionality factors (RDFs), or excisionases, are essential players of prophage excisive recombination. Despite the essentially catalytic role of the integrase in both integrative and excisive recombination, RDFs are required to direct ...
Mireille Ansaldi, Vincent Méjean, Gaël Panis, Nathalie Franche   +3 more
doaj   +1 more source

HIV-1 integrase genotyping is reliable and reproducible for routine clinical detection of integrase resistance mutations even in patients with low-level viraemia.

Journal of Antimicrobial Chemotherapy, 2015
OBJECTIVES Integrase drug resistance monitoring deserves attention because of the increasing number of patients being treated with integrase strand-transfer inhibitors.
D. Armenia, L. Fabeni, C. Alteri, D. D. Pinto, Domenico Di Carlo, A. Bertoli, C. Gori, Stefania Carta, Valentina Fedele, F. Forbici, R. D'arrigo, V. Svicher, G. Berno, Daniele Pizzi, E. Nicastri, L. Sarmati, C. Pinnetti, A. Ammassari, Gianpiero D’Offizi, A. Latini, M. Andreoni, Armando Antinori, F. Ceccherini‐Silberstein, C. Perno, M. Santoro   +24 more
semanticscholar   +1 more source

Characterization of the Functional Domains of Human Foamy Virus Integrase Using Chimeric Integrases

Molecules and Cells, 2005
Retroviral integrases insert viral DNA into target DNA. In this process they recognize their own DNA specifically via functional domains. In order to analyze these functional domains, we constructed six chimeric integrases by swapping domains between HIV-1 and HFV integrases, and two point mutants of HFV integrase.
Hak Sung, Lee, Seung Yi, Kang, Cha-Gyun, Shin   +2 more
openaire   +2 more sources

Differences in clinical characteristics between adolescents and young adults with perinatally and sexually acquired HIV in the Asia‐Pacific region

Journal of the International AIDS Society, Volume 28, Issue 4, April 2025.
Abstract Introduction We assessed the long‐term HIV‐related health outcomes of young adults with perinatally acquired HIV (PHIV) compared with those who acquired HIV through sexual transmission in the Asia‐Pacific region. Methods We conducted a cross‐sectional study using data from three paediatric and adult cohorts within the International ...
Phatharajit Phatharodom, Alan Maleesatharn, Tavitiya Sudjaritruk, Suwimon Khusuwan, Kathy Petoumenos, Linda Aurpibul, Romanee Chaiwarith, Michelle L. Giles, Du Tuan Quy, Smita Nimkar, Alvina Widhani, Junko Tanuma, Matthew Law, Annette H. Sohn, Kulkanya Chokephaibulkit, IeDEA Asia‐Pacific   +15 more
wiley   +1 more source

Conserved residues Pro-109 and Asp-116 are required for interaction of the human immunodeficiency virus type 1 integrase protein with its viral DNA substrate [PDF]

, 1993
Meera Drelich, Markus Haenggi, Jan Mous
openalex   +1 more source

Phenotypic Characterization of Replication‐Impaired Lenacapavir‐Resistant HIV Clinical Isolates

Journal of Medical Virology, Volume 97, Issue 4, April 2025.
ABSTRACT Lenacapavir (LEN) is a potent, first‐in‐class long‐acting HIV‐1 capsid (CA) inhibitor, approved for treatment of people with multi‐drug resistant HIV in combination with other antiretrovirals. In clinical studies with LEN, the CA resistance‐associated mutations (RAMs) M66I, Q67H/K/N, K70H/N/R/S, N74D/H/K, A105S/T, and T107A/C/N/S were observed.
Sally Demirdjian, Vidula Naik, Nicolas Margot, Brie Falkard, Christian Callebaut   +4 more
wiley   +1 more source

Increased stable integration efficiency in CHO cells through enhanced nuclear localization of Bxb1 serine integrase

BMC Biotechnology
Background Mammalian display is an appealing technology for therapeutic antibody development. Despite the advantages of mammalian display, such as full-length IgG display with mammalian glycosylation and its inherent ability to select antibodies with ...
Olli Huhtinen, Stuart Prince, Urpo Lamminmäki, Rune Salbo, Antti Kulmala   +4 more
doaj   +1 more source

Major antigenic region on the integrase (IN) protein of human immunodeficiency virus type 1 determined by reactivity of human sera and a monoclonal antibody to IN protein [PDF]

, 1994
Y Tachibana, Atsushi Yasuda, Takayasu Kurata, Shinichi Oka, K. Shimada, Asato Kojima   +5 more
openalex   +1 more source