Results 121 to 130 of about 49,053 (243)

Emerging Dissemination of blaCTX‐M‐65 in Bovine E. coli in Spain Associated With IncHI2 Plasmids

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
The resistome in ESBL/AmpC‐producing E. coli in livestock was diverse and dominated by plasmid‐borne genes Detection of host‐independent dissemination of AMR determinants mediated by shared plasmid types First report in Spanish cattle of blaCTX‐M‐65 on IncHI2 plasmids, an under‐reported ESBL in Europe Identification of potentially zoonotic clones in ...
Medelin Ocejo, Beatriz Oporto, Ana Hurtado   +2 more
wiley   +1 more source

Wastewater‐Based Assessment of Antimicrobial Resistance and Bacterial Communities in Urban and Rural Areas in the Province of Trento (Italy)

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Wastewater from urban and rural areas was analyzed to investigate antimicrobial‐resistant bacteria and resistance genes. ESBL‐Escherichia coli and genes coding for clinically relevant resistances, namely, those to macrolides, carbapenems, and vancomycin, were higher in urban than in rural areas.
Maya Petricciuolo, Agnese Carnevali, Alessia Torboli, Mattia Postinghel, Alessia Guasticchi, Paola Foladori, Maria Cadonna, Ermanno Federici   +7 more
wiley   +1 more source

HIV Dynamics and Integrase Inhibitors

Antiviral Chemistry and Chemotherapy, 2009
The integrase inhibitor (INI) raltegravir has shown promising results in clinical trials to date, reducing second phase HIV RNA levels by 70% in comparison with standard regimens. These trial results have been limited by the 50 copies/ml detection limit of the HIV RNA assay and have not investigated the effect of an INI regimen on levels of latently ...
openaire   +2 more sources

Natural polymorphisms of human immunodeficiency virus type 1 integrase and inherent susceptibilities to a panel of integrase inhibitors.

, 2009
We evaluated the human immunodeficiency virus type 1 (HIV-1) integrase coding region of the pol gene for the presence of natural polymorphisms in patients during early infection (AHI) and with triple-class drug-resistant HIV-1 (MDR). We analyzed selected
Daria Hazuda, Andrea Low, Florin Vaida, Hiroshi Mohri, Vaida, Florin, Muesing, Mark, Markowitz, Martin, Delivette Castor, Low, Andrea, Prada, Nicole, Mark Muesing, Nicole Prada, Castor, Delivette, Michael Topper, Hazuda, Daria, Topper, Michael, Martin Markowitz, Mohri, Hiroshi   +17 more
core   +1 more source

Increased stable integration efficiency in CHO cells through enhanced nuclear localization of Bxb1 serine integrase

BMC Biotechnology
Background Mammalian display is an appealing technology for therapeutic antibody development. Despite the advantages of mammalian display, such as full-length IgG display with mammalian glycosylation and its inherent ability to select antibodies with ...
Olli Huhtinen, Stuart Prince, Urpo Lamminmäki, Rune Salbo, Antti Kulmala   +4 more
doaj   +1 more source

Repurposed Medicines for Viruses With Epidemic or Pandemic Potential: A Horizon Scan

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Viruses such as Ebola, Marburg, influenza, mpox, MERS‐CoV, SARS‐CoV, and SARS‐CoV‐2 may be considered pathogens of epidemic or pandemic concern. Developing novel antiviral medicines can be time‐consuming and resource intensive. Repurposing existing medicines with known or potential antiviral activity offers a faster, cost‐effective strategy to
Sola Akinbolade, Rhiannon Potter, Alex Inskip, Jane Nesworthy, Kirsti Brock, Gill Norman   +5 more
wiley   +1 more source

Computer tools in the discovery of HIV-1 integrase inhibitors

, 2010
Computer-aided drug design (CADD) methodologies have made great advances and contributed significantly to the discovery and/or optimization of many clinically used drugs in recent years.
Chenzhong Liao, Marc C Nicklaus
core   +1 more source

Detection of an integrase gene in clinical isolates of Mycobacterium tuberculosis

International Journal of Mycobacteriology, 2015
Introduction: Drug resistance in Mycobacterium tuberculosis (MTB) is caused by many mechanisms. Integrons are genetic units characterized by their ability to capture and incorporate bacterial genomes by recombination and may contain resistance-related ...
M Arjomandzadegan, A Ahmadi, F Salehi, S Falaht   +3 more
doaj  

The evolving role of structural biology in pharma: integration of X‐ray crystallography, cryo‐electron microscopy and beyond

Acta Crystallographica Section D, Volume 82, Issue 6, Page 587-602, June 2026.
This review describes how an integrated structural biology platform at Merck Sharp & Dohme LLC, Rahway, New Jersey, USA, combining X‐ray crystallography, cryo‐EM, MicroED and cryo‐ET, enables seamless three‐dimensional insights from molecular to cellular length scales.
Jill E. Chrencik, Hua-Poo Su, Yacob Gomez Llorente, Rachel L. Palte, Daniel J. Klein, Robert P. Hayes, Sadie P. Antine, Guilermo A. Asmar-Rovira, Nicole Bertoletti, Noel J. Byrne, Brittany L. Carroll, Ciro D. Cordeiro, Kaylynn Curfman, James Dutko, Michael J. Eddins, Thierry Fischmann, Barani Govindarajan, Corey W. Hecksel, Thu Ho, Kaspar Hollenstein, Mee Ra Hong, Alan Hruza, Andrii Ishchenko, Maru Jaime-Garza, Matt J. Jaremko, Hayley L. Knox, James Kostas, Harini Krishnamurthy, Ioannis Manolaridis, Cameron L. Noland, Andrea T. Partridge, Sangita B. Patel, Paul Reichert, John C. Reid, Catarina Felisberto-Rodrigues, Chitra A. Shintre, Jennifer M. Shipman, Elakkiya Tamilselvan, Morgan E. Walker, Susanne N. Walker, Renjing Wang, Katharine M. Wright, Tien-Jui Yen, Byung-Kuk Yoo, Sandra B. Gabelli   +44 more
wiley   +1 more source

Isolation of a Novel Lytic Pseudomonas aeruginosa Phage Henu5 and Fitness Costs of Phage‐Driven Resistance

Microbial Biotechnology, Volume 19, Issue 6, June 2026.
This study isolated and identified a novel lytic phage that infects Pseudomonas aeruginosa. Henu5 exhibited good physicochemical stability. Additionally, the phage‐resistant mutants showed fitness trade‐offs in growth, virulence and antibiotic susceptibility, along with in vivo fitness, which might direct future phage selection in clinical settings ...
Salwa E. Gomaa, Jiawen Shen, Jingjing Li, Yangyang Liu, Chaonan Ma, Qiming Li, Guanbin Qi, Tieshan Teng   +7 more
wiley   +1 more source