Results 141 to 150 of about 49,053 (243)
Functional Oligomeric State of Avian Sarcoma Virus Integrase
, 2003 Retroviral integrase, one of only three enzymes encoded by the virus, catalyzes the essential step of inserting a DNA copy of the viral genome into the host during infection.
Bao, Kogan K. +5 more
core +1 more source
Characterization and structural analysis of HIV-1 integrase conservation
, 2009 The HIV-1 integrase, responsible for the chromosomal integration of the newly synthesized double-stranded viral DNA into the host genomic DNA, represents a new and important target of potential clinical relevance.
Perno, CF +7 more
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A hybrid lentivirus-transposon vector for safer gene therapy
, 2010 Gene therapy vectors based on the HIV-1 lentivirus are an attractive option for clinical applications because they enter a broad range of target cells efficiently and deliver stable gene expression through integration into host chromosomes.
Vink, C.A.
core
A structure-function analysis of P2 integrase
Bacteriophage P2 integrase catalyzes site-specific recombination between the phage DNA and the host chromosome thereby promoting integration or excision of the phage genome.
Sylwan, Lina, +4 more
core
Biological Research, 2008 Processing of viral DNA by retroviral integrase leaves a dinucleotide single-strand overhang in the unprocessed strand. Previous studies have stressed the importance of the 5' single-stranded (ss) tail in the integration process.
JORGE VERA +3 more
doaj
Development of an HIV-1 integrase enzyme strand transfer assay
, 2011 The Human Immunodeficiency Virus type 1 (HIV-1) integrase is an essential enzyme required for viral replication. Integrase forms part of an ensemble of proteins known as the preintegration complex and functions by a two-step process.
Qasim, Muhammad
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HIV-1 Sub-subtype A6 Remains Susceptible to Second-Generation Integrase Inhibitors With Limited Emergence of Resistance in Vitro. [PDF]
Open Forum Infect DisSaladini F +11 more
europepmc +1 more source
, 1998 Mycobacteriophage D29 is a lytic phage that infects both fast- and slow-growing species of the mycobacteria. D29 forms clear plaques on lawns of Mycobacterium smegmatis and Mycobacterium bovis bacille Calmette-Guérin (BCG) in which a very high proportion
Hatfull, Graham F. +2 more
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