Results 111 to 120 of about 49,053 (243)

Timely and Efficient Infant Diagnosis Is Required to End AIDS in Children

Journal of the International AIDS Society, Volume 29, Issue S1, June 2026.
ABSTRACT Introduction Though considerable effort and investment has significantly increased the proportion of pregnant women living with HIV accessing lifesaving antiretroviral therapy and lowered the prevalence of vertical HIV transmission, more than 70,000 children die each year due to AIDS‐related deaths, and nearly half of the 1.4 million children ...
Lara Vojnov, Ilesh V. Jani
wiley   +1 more source

HIV-1 Integrase Drug Discovery Comes of Age

, 2014
Insertion of the viral genome into host cell chromatin is a pivotal step in the replication cycle of the human immunodeficiency virus and other retroviruses.
Zeger Debyser, Demeulemeester, Jonas, Debyser, Zeger, Marc De Maeyer, De Maeyer, Marc, Jonas Demeulemeester   +5 more
core   +1 more source

High prevalence of integrase mutation L74I in West African HIV-1 subtypes prior to integrase inhibitor treatment.

, 2020
OBJECTIVES: HIV-1 integrase inhibitors are recommended as first-line therapy by WHO, though efficacy and resistance data for non-B subtypes are limited.
El Bouzidi, K, Murtala-Ibrahim, F, El Bouzidi, Kate, Breuer, J, Roy, Sunando, Gupta, RK, Datir, RP, Murtala-Ibrahim, Fati, Bonsall, David, Ndembi, N, Kwaghe, Vivian, Breuer, Judith, Kemp, SA, Dakum, P, Ndembi, Nicaise, Datir, Rawlings P, Fraser, C, Sabin, Caroline A, Fraser, Christophe, Sabin, CA, Golubchik, Tanya, Roy, S, Ogbanufe, Obinna, Aliyu, A, Kemp, Steven A, Aliyu, Ahmad, Kwaghe, V, Frampton, D, Charurat, ME, Bonsall, D, Gupta, Ravindra K, Golubchik, T, Charurat, Man E, Ogbanufe, O, Frampton, Dan, Dakum, Patrick   +35 more
core   +1 more source

Design, synthesis, molecular dynamics studies and biological evaluations of 4-hydroxy-5-pyrrolinone-3-carbohydrazides as HIV-1 integrase inhibitors

European Journal of Medicinal Chemistry Reports
Acquired immune deficiency syndrome (AIDS) diseases despite the efficacy of anti-HIV therapy, remain one of the human's most serious problems. Hence, the introduction of novel anti-HIV agents as first-line therapy is still required. HIV integrase lacking
Nafiseh Karimi, Amirreza Dowlati Beirami, Rouhollah Vahabpour Roudsari, Zahra Hajimahdi, Afshin Zarghi   +4 more
doaj   +1 more source

Baseline Data on Viral Suppression, Treatment Adherence and Mental Health in Peripartum Girls and Young Women With HIV in Zimbabwe

Journal of the International AIDS Society, Volume 29, Issue S1, June 2026.
ABSTRACT Introduction Peripartum adolescent girls and young women (AGYW) with HIV have lower viral suppression compared to older women. But the recently introduced dolutegravir‐based regimens and psychosocial peer motivation may improve viral control.
Tariro D. Chawana‐Mutingwende, Bernard Ngara, Leon‐Say Mudadi, Thelma T. Tauya, Marvelous Sibanda, Mercy Mutambanengwe‐Jacob, Precious Andifasi, Bernadette Malunda, Tinashe Chidemo, Annie Mapfunde, Sandra Nyakudya, Anna Z. Mufumisi, Thandiwe H. Chirenda, Tobias Chitambo, Walter T. S. Nderecha, Constance Murandu, Miriam Gwande, Kudakwashe Muringayi, Rhoda Micah Bongo, Hideaki Okochi, Karen Kuncze, Angela Mushavi, Nicola Willis, Karen Webb, Monica Gandhi, Lynda Stranix‐Chibanda   +25 more
wiley   +1 more source

Cause of Death and Risk of Death for People Living With HIV Admitted to Hospital: A Systematic Review and Meta‐Analysis

Journal of the International AIDS Society, Volume 29, Issue 6, June 2026.
ABSTRACT Introduction Despite increasing access to HIV treatment and care, HIV‐associated deaths remain high. We aimed to summarize global and regional trends in risk and causes of death among people living with HIV (PLHIV) admitted to hospital. Methods We conducted a systematic search across eight databases on 23 April 2023, identifying studies that ...
Rachael M. Burke, Nadia Sabet, Jayne Ellis, Hannah M. Rickman, Ajay Rangaraj, David S. Lawrence, Joseph N. Jarvis, Jane Falconer, Lillian Tugume, Rebecca H. Berhanu, Nathan Ford, Peter MacPherson   +11 more
wiley   +1 more source

Novel therapeutic strategies targeting HIV integrase

, 2012
Integration of the viral genome into host cell chromatin is a pivotal and unique step in the replication cycle of retroviruses, including HIV. Inhibiting HIV replication by specifically blocking the viral integrase enzyme that mediates this step is an ...
Sloan Richard D, Wainberg Mark A, Quashie Peter K   +2 more
core   +1 more source

Characterization of HIV-1 Integrase Gene and Resistance Associated Mutations Prior to Roll out of Integrase Inhibitors by Kenyan National HIV-Treatment Program in Kenya

, 2020
BACKGROUND: Antiretroviral therapy containing an integrase strand transfer inhibitor plus two Nucleoside Reverse Transcriptase inhibitors has now been recommended for treatment of HIV-1-infected patients.
Lihana Raphael, Sepha, Mabeya, Nyerere Andrew, Nyamache Anthony, Ngugi Caroline   +4 more
core   +1 more source

Genome‐Wide In Silico Analysis of the Type VI Secretion System (T6SS) Within the Morganella Genus

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
▪ Species‐specific T6SS patterns among Morganella genus (M. morganii and M. sibonii). ▪ Only one‐third of M. morganii isolates haboured a T6SS. ▪ All M. sibonii possess four T6SS clusters. ▪ M. sibonii exhibited a wide diversity of effectors compared to M. morganii.
Mathilde Duque, Aymeric Jacquemin, Delphine Girlich, Rémy A. Bonnin, Laurent Dortet   +4 more
wiley   +1 more source

Unveiling Marine Vesicle Uptake in Vibrio spp: Taxonomic and Environmental Insights

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Extracellular vesicles are involved in diverse functions in nature from microbial interactions to pathogenesis. Here, we investigate whether taxonomy represents a boundary that constrains the uptake of vesicles between different marine bacteria including ubiquitous Vibrio spp. involved in marine organism diseases, such as corals.
Nadefa Adda Nekrouf, Lucia Maestre‐Carballa, Monica Lluesma‐Gomez, Esther Rubio‐Portillo, Manuel Martinez‐Garcia   +4 more
wiley   +1 more source