Results 91 to 100 of about 49,053 (243)
AFM observation of integrase-target DNA complexes.
, 2013 (A, B) Target DNA xkyk bound to HIV-1 integrase forming a loop-like structure or (C) a figure-eight-like structure. (D) DNA showing no HIV-1 integrase binding, where the arrow indicates unbound integrase.
Keiji Tamaki (289142) +5 more
core +1 more source
HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors
eLife, 2019 Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are a promising new class of antiretroviral agents that disrupt proper viral maturation by inducing hyper-multimerization of IN.
Pratibha C Koneru +14 more
doaj +1 more source
Potential unlocked: an atlas of cloned wheat genes for genome engineering and breeding
New Phytologist, EarlyView.Strategies for introducing genome edits into a wheat breeding program and their effects on cultivar longevity. Summary Bread wheat (Triticum aestivum) production is increasingly threatened by biotic and abiotic stresses. Developing varieties with improved stress tolerance and desirable end‐use qualities is crucial for meeting growing global demand ...
Abdulrahman Alhabsi +7 more
wiley +1 more source
Lambda Integrase: Armed for Recombination [PDF]
Current Biology, 2005 Bacteriophage lambda moves its viral genome into and out of the bacterial chromosome using site-specific recombination. Crystal structures of reaction intermediates in this recombination pathway provide exciting new snapshots of full length lambda integrase interacting with both core and regulatory DNA elements.
openaire +2 more sources
, 2017 HIV-1 subtype frequency among pre- and on-treatment integrase genotypes with or without T97A integrase mutation.
Michael D. Miller (253934) +6 more
core +1 more source
Applied and Environmental MicrobiologyOver the past three decades, the integrase (Int) from Streptomyces phage phiC31 has become a valuable genome engineering tool across various species. phiC31 Int was thought to mediate unidirectional site-specific integration (attP × attB to attL and attR)
Yadan Duan +6 more
doaj +1 more source
Insights into the Functions of a Prophage Recombination Directionality Factor
Viruses, 2012 Recombination directionality factors (RDFs), or excisionases, are essential players of prophage excisive recombination. Despite the essentially catalytic role of the integrase in both integrative and excisive recombination, RDFs are required to direct ...
Mireille Ansaldi +3 more
doaj +1 more source
Journal of the International AIDS Society, Volume 29, Issue 7, July 2026.ABSTRACT Introduction Multi‐month dispensing (MMD), as a differentiated service delivery model, can reduce the frequency of clinic visits, waiting time and travel costs for clinically stable people living with HIV. This study aimed to evaluate the impact of 6‐month MMD of antiretroviral therapy (ART) on retention and conduct a cost analysis in China ...
Wenqi Shang +8 more
wiley +1 more source
Multifunctional facets of retrovirus integrase
World Journal of Biological Chemistry, 2015 The retrovirus integrase (IN) is responsible for integration of the reverse transcribed linear cDNA into the host DNA genome. First, IN cleaves a dinucleotide from the 3' OH blunt ends of the viral DNA exposing the highly conserved CA sequence in the recessed ends.
Duane P, Grandgenett +3 more
openaire +2 more sources
Affinity Proteomics‐Based Non‐Invasive Detection of Clinically Significant Liver Disease
Alimentary Pharmacology &Therapeutics, Volume 64, Issue 1, Page 74-88, July 2026.Using UK Biobank proteomic data, we identified a five‐protein score reflecting hepatic stellate cell activation and hepatocellular injury that predicts major adverse liver outcomes and clinically significant fibrosis, with consistent performance validated in two independent cohorts (patients with HIV and alpha1‐antitrypsin deficiency).
Sriram Balasubramani +14 more
wiley +1 more source