Results 101 to 110 of about 52,284 (201)

Increased stable integration efficiency in CHO cells through enhanced nuclear localization of Bxb1 serine integrase

BMC Biotechnology
Background Mammalian display is an appealing technology for therapeutic antibody development. Despite the advantages of mammalian display, such as full-length IgG display with mammalian glycosylation and its inherent ability to select antibodies with ...
Olli Huhtinen, Stuart Prince, Urpo Lamminmäki, Rune Salbo, Antti Kulmala   +4 more
doaj   +1 more source

A hybrid lentivirus-transposon vector for safer gene therapy [PDF]

, 2010
Gene therapy vectors based on the HIV-1 lentivirus are an attractive option for clinical applications because they enter a broad range of target cells efficiently and deliver stable gene expression through integration into host chromosomes.
Vink, C.A.
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Hepatic Steatosis in People With Chronic Hepatitis B in Africa: Prevalence, Correlates, and Clinical Significance

Journal of Viral Hepatitis, Volume 33, Issue 11, November 2026.
ABSTRACT To address data gaps around metabolic liver disease in Africa, within the Hepatitis B in Africa Collaborative Network (HEPSANET), we evaluated participants with chronic hepatitis B virus infection (CHB) for steatotic liver disease (SLD) using transient elastography with controlled attenuation parameter (CAP).
Freeman W. Chabala, Edford Sinkala, Alana T. Brennan, Amy Miskimon Goss, Lamin Bojang, Yusupha Samateh, Alexander J. Stockdale, Roger Sombie, Arouna Sessouma, Alice Nanelin Guingane, Juste Aristide Goungounga, Mohamed El‐Kassas, Eman Marwan, Ibrahima Diallo, Abdoul Sow, Edith Okeke, Attah Okwute, Hans Prozesky, Zahiera Ismail, Mark Sonderup, C. Wendy Spearman, Philippa C. Matthews, Judicaël Malick Tine, Maud Lemoine, Hailemichael Desalegn Mekonnen, Asgeir Johnannessen, Michael J. Vinikoor, on behalf of Hepatitis B in Africa Collaborative Network (HEPSANET), Alice Guingane, Roger Sombie, Asgeir Johannessen, Edith Okeke, Mohamed El‐Kassas, Gilles Wandeler, Ibrahima Diallo, Joan Rugemalila, Wendy Spearman, Hans Prozesky, Alex Stockdale, Maud Lemoine, Babatunde Duduyemi, Mary Afihene, Edford Sinkala, Asgeir Johannessen, Roger Sombie, Alex Stockdale, Alice Guingane, Michael Vinikoor, Edith Okeke, Maud Lemoine, Philippa Matthews, Wendy Spearman, Adria Ramirez   +52 more
wiley   +1 more source

Styrylquinolines, integrase inhibitors acting prior to integration: a new mechanism of action for anti-integrase agents.

, 2004
International audienceWe have previously shown that styrylquinolines (SQLs) are integrase inhibitors in vitro. They compete with the long terminal repeat substrate for integrase. Here, we describe the cellular mode of action of these molecules.
Vita, Claudio, Mouscadet, Jean-François, Subra, Frédéric, Desmaële, Didier, Zouhiri, Fatima, Thomas, Claire Marie, Deprez, Eric, Leh, Hervé, Bonnenfant, Sabine, d'Angelo, Jean   +9 more
core   +1 more source

Medicinal Chemistry Aspects of Thiazole and Thiazolidine Derivatives as Fundamental Building Blocks to Design New NNRTIs Against HIV‐1 Reverse Transcriptase

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
HIV‐1 reverse transcriptase (HIV‐1 RT) is a polymerase enzyme and a key target in HIV‐1 therapy. The discovery of selective HIV‐1 RT inhibitors has highlighted thiazole scaffolds and their derivatives, thiazolidine‐2‐one and thiazolidine‐2,4‐dione, as promising structures for the rational design of novel non‐nucleoside reverse transcriptase inhibitors (
José Arion da Silva Moura, Matheus Vinicius Guimarães de Melo, Diane Regis Santos do Nascimento, Thaynara Paula Warren Bezerra, Mathieu Métifiot, Patricia Recordon‐Pinson, Maira Galdino da Rocha Pitta, Marina Galdino da Rocha Pitta, Michelly Cristiny Pereira, Marie‐Line Andreola   +9 more
wiley   +1 more source

Variable orthogonality of serine integrase interactions within the ϕC31 family

Scientific Reports
Serine integrases are phage- (or mobile element-) encoded enzymes that catalyse site-specific recombination reactions between a short DNA sequence on the phage genome (attP) and a corresponding host genome sequence (attB), thereby integrating the phage ...
Alasdair I. MacDonald, Aron Baksh, Alexandria Holland, Heewhan Shin, Phoebe A. Rice, W. Marshall Stark, Femi J. Olorunniji   +6 more
doaj   +1 more source

Challenges and Future Directives of Synthetic Biology in Engineering Plant–Microbe Partnerships for Sustainable Agriculture

Biotechnology and Bioengineering, Volume 123, Issue 10, Page 2491-2519, October 2026.
ABSTRACT Synthetic biology has recently proven to be a valuable tool for enhancing agriculture even in the face of environmental and biological stresses. Understanding the challenges that militate synthetic biology will assist in ensuring safe, stable, and scalable crop production.
Ben Jesuorsemwen Enagbonma, Rebaona Reaobaka Molefe‐Madlaliso, Alaba Adewole Adebayo, Oghoye Priscilla Oyedoh, Godfrey Okainemen Oribhabor, Oluwaseun Emmanuel Shittu, Olubukola Oluranti Babalola   +6 more
wiley   +1 more source

Detection of an integrase gene in clinical isolates of Mycobacterium tuberculosis

International Journal of Mycobacteriology, 2015
Introduction: Drug resistance in Mycobacterium tuberculosis (MTB) is caused by many mechanisms. Integrons are genetic units characterized by their ability to capture and incorporate bacterial genomes by recombination and may contain resistance-related ...
M Arjomandzadegan, A Ahmadi, F Salehi, S Falaht   +3 more
doaj  

Traditional Uses, Phytochemistry, and Multi‐Target Pharmacological Activities of Senna alexandrina

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Senna alexandrina is a medicinally important plant with documented use across Traditional Chinese, Islamic, Ayurvedic, and Unani medicine systems. Phytochemical investigations have yielded 219 characterized compounds, predominantly anthraquinones, flavonoids, and polysaccharides, distributed across leaves, pods, and aerial parts.
Diana Afrina Rella, Khai‐Lin Hew, Yeun‐Mun Choo   +2 more
wiley   +1 more source

Characterization of HIV-1 Integrase Reactions with Viral DNA [PDF]

, 2013
HIV-1 integrase (integrase) catalyzes the insertion of viral DNA into human chromosomes and is a focus for development of anti-integrase inhibitors to combat HIV infection. Integrase catalyzes two steps, a DNA-end cleavage reaction (3’-processing), and a
Kettlewell, Joanna
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