Results 101 to 110 of about 49,053 (243)

Nickel Photocatalytic Access to β‐Arylated β‐Amino Acids

Advanced Synthesis &Catalysis, Volume 368, Issue 12, 17 June 2026.
Converting naturally abundant amino acids to non‐canonical derivatives in one step under mild conditions allows for improved pharmaceutical properties. Now, this is achieved for β‐arylated β‐amino acids, which are available in good yields directly from aspartic acid, and have the potential to become platform chemicals for drug discovery.
Tim S. Stamp, Ning Wei, Laura K. C. Zedelmair, Sebastian B. Beil   +3 more
wiley   +1 more source

Comparison Between Several Integrase-defective Lentiviral Vectors Reveals Increased Integration of an HIV Vector Bearing a D167H Mutant

Molecular Therapy: Nucleic Acids, 2014
HIV-1 derived vectors are among the most efficient for gene transduction in mammalian tissues. As the parent virus, they carry out vector genome insertion into the host cell chromatin.
Muhammad Qamar Saeed, Noelle Dufour, Cynthia Bartholmae, Urzula Sieranska, Malaika Knopf, Eloïse Thierry, Sylvain Thierry, Olivier Delelis, Nicolas Grandchamp, Héloïse Pilet, Philippe Ravassard, Julie Massonneau, Françoise Pflumio, Christof von Kalle, François Lachapelle, Alexis-Pierre Bemelmans, Manfred Schmidt, Ché Serguera   +17 more
doaj   +1 more source

Opportunities and Challenges for Surveillance of Congenital Anomalies in Sub‐Saharan Africa

Birth Defects Research, Volume 118, Issue 6, June 2026.
ABSTRACT Introduction Congenital anomalies (CA) are ranked as the 3rd and 4th leading cause of neonatal and under‐5 mortality, respectively. Over 30% of infants born with a serious CA are found in sub‐Saharan Africa. Yet there are few robust epidemiological data on the burden and distribution of CA and associated mortality, disability, and morbidity ...
Emma Kalk, Helen Louise Malherbe, Ushma C. Mehta, Daniel Mumpe‐Mwanja, Modiegi Dianah Diseko, Adejumoke Idowu Ayede, Phyllis Kisa, Caroline Bonareri Osoro, George Bello, Lee Fairlie, Audrey Chepkemoi, Hamisi K. Shabani, Ali Sie, Samrawit Abebaw Tegene, Robert Serunjogi, Aminkeng Zawuo Leke, Helen Dolk, Linda Barlow Mosha, on behalf of the sub‐Saharan African Congenital Anomalies Network (sSCAN)   +18 more
wiley   +1 more source

Styrylquinolines, integrase inhibitors acting prior to integration: a new mechanism of action for anti-integrase agents.

, 2004
International audienceWe have previously shown that styrylquinolines (SQLs) are integrase inhibitors in vitro. They compete with the long terminal repeat substrate for integrase. Here, we describe the cellular mode of action of these molecules.
Vita, Claudio, Mouscadet, Jean-François, Subra, Frédéric, Desmaële, Didier, Zouhiri, Fatima, Thomas, Claire Marie, Deprez, Eric, Leh, Hervé, Bonnenfant, Sabine, d'Angelo, Jean   +9 more
core   +1 more source

The Chemical Structures, Neuroprotective Effects, Structure–Activity Relationships, and Applications of Flavonoids, Phenolic Acids, Terpenoids, and Sterols in Dandelion: A Review

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
This review systematically summarizes the chemical structures and structure–activity relationships of key bioactive compounds in dandelion, including flavonoids, phenolic acids, terpenoids, and sterols. It highlights their neuroprotective mechanisms against neuroinflammation and oxidative stress, while outlining their promising dual applications in the
Hongye Li, Bingchan Qu, Jiasu Wu, Menghan Sun, Youlin Xue, Tiejing Li, Chang Tan, Shan Wang, Chong Ning, Chongting Guo   +9 more
wiley   +1 more source

The SSV1 viral integrase is not essential

Virology, 2007
Viral integration is a widely conserved characteristic in viruses in all domains of life; however, its necessity is not well understood in many cases. Integration using tyrosine recombinases is one of the most widespread and best characterized mechanisms of integration. We completely removed the tyrosine recombinase integrase from the hyperthermophilic
Clore, Adam J., Stedman, Kenneth M.
openaire   +2 more sources

Development and application of non-integrating lentiviral vectors for gene therapy

, 2009
Lentiviruses stably integrate their genome into the host genome. Although this feature can be advantageous for long term transgene expression, it also has the potential to cause mutagenesis and cell transformation.
Apolonia, L.F.S.
core  

A Global Health Alert on the Re‐Emergence of Mpox a Viral Zoonotic Illness Its Prevention and Management: A Narrative Review

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Monkeypox virus (MPXV) is gaining attention in the global health community due to its potential for human transmission and similarities to the well‐known smallpox virus. Mpox was first detected in the 1970s and mostly affects Central and West Africa.
Muslim Bin Aqeel, Asif Hanif, Shahzad Ahmad, Fatima Iftikhar Shah, Benish Javed, Shazia Iqbal   +5 more
wiley   +1 more source

Integrase-LexA Fusion Proteins Incorporated into Human Immunodeficiency Virus Type 1 That Contains a Catalytically Inactive Integrase Gene Are Functional To Mediate Integration

, 2000
Purified fusion proteins made up of a retroviral integrase and a sequence-specific DNA-binding protein have been tested in in vitro assays for their ability to direct integration into specific target sites.
Samson A. Chow, Michelle L. Holmes-Son
core   +1 more source

Resistance to inhibitors of the human immunodeficiency virus type 1 integration

Brazilian Journal of Infectious Diseases
This review will summarize the role of integrase in HIV-1 infection, the mechanism of integrase inhibitors and resistance with an emphasis on raltegravir (RAL), the first integrase inhibitor licensed to treat HIV-1 ...
Daria J Hazuda
doaj   +1 more source